Results 31 to 40 of about 2,207,666 (298)

Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry.

PLoS Pathogens, 2021
Coronavirus interaction with its viral receptor is a primary genetic determinant of host range and tissue tropism. SARS-CoV-2 utilizes ACE2 as the receptor to enter host cell in a species-specific manner.
Wenlin Ren, Yunkai Zhu, Yuyan Wang, Hongyang Shi, Yin Yu, Gaowei Hu, Fei Feng, Xiaomin Zhao, Jun Lan, Jianping Wu, Devin J Kenney, Florian Douam, Yimin Tong, Jin Zhong, Youhua Xie, Xinquan Wang, Zhenghong Yuan, Dongming Zhou, Rong Zhang, Qiang Ding   +19 more
doaj   +1 more source

Ebola virus triggers receptor tyrosine kinase-dependent signaling to promote the delivery of viral particles to entry-conducive intracellular compartments.

PLoS Pathogens, 2021
Filoviruses, such as the Ebola virus (EBOV) and Marburg virus (MARV), are causative agents of sporadic outbreaks of hemorrhagic fevers in humans. To infect cells, filoviruses are internalized via macropinocytosis and traffic through the endosomal pathway
Corina M Stewart, Alexandra Phan, Yuxia Bo, Nicholas D LeBlond, Tyler K T Smith, Geneviève Laroche, Patrick M Giguère, Morgan D Fullerton, Martin Pelchat, Darwyn Kobasa, Marceline Côté   +10 more
doaj   +1 more source

Clathrin Mediated Endocytosis and its Role in Viral Entry [PDF]

, 2013
Deep insight on Clathrin Mediated Endocytosis and its Role in Viral ...
Tourdot, R, Radhakrishnan, R
core   +1 more source

SLC38A9 regulates SARS-CoV-2 viral entry

iScience
Summary: SARS-CoV-2 viral entry into host cells depends on the cleavage of spike (S) protein into S1 and S2 proteins. Such proteolytic cleavage by furin results in the exposure of a multibasic motif on S1, which is critical for SARS-CoV-2 viral infection
Gaurav Datta, Neda Rezagholizadeh, Wendie A. Hasler, Nabab Khan, Xuesong Chen   +4 more
doaj   +1 more source

Systematic Investigation of SARS-CoV-2 Receptor Protein Distribution along Viral Entry Routes in Humans [PDF]

, 2022
The novel beta-coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), enters the human body via mucosal surfaces of the upper and/or lower respiratory tract.
Wartenberg, M., Schürch, Christian M., Galván, J.A., Reinhard, Stefan, Galván, José A., Wartenberg, Martin, Bräutigam, K., Hewer, Ekkehard, Hewer, E., Schürch, C.M., Bräutigam, Konstantin, Reinhard, S., José A. Galván, Christian M. Schürch, Konstantin Bräutigam, Ekkehard Hewer, Stefan Reinhard, Martin Wartenberg   +17 more
core   +1 more source

Therapeutic development targeting host heparan sulfate proteoglycan in SARS-CoV-2 infection

Frontiers in Medicine
The global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent need for effective therapeutic options.
Qi Zhang, Ivan Pavlinov, Yihong Ye, Wei Zheng   +3 more
doaj   +1 more source

Role of lipids on entry and exit of bluetongue virus, a complex non-enveloped virus. [PDF]

, 2010
Non-enveloped viruses such as members of Picornaviridae and Reoviridae are assembled in the cytoplasm and are generally released by cell lysis. However, recent evidence suggests that some non-enveloped viruses exit from infected cells without lysis ...
Roy, Polly, Bishnupriya Bhattacharya, Bhattacharya, Bishnupriya, Polly Roy, Bhattacharya, Roy   +5 more
core   +1 more source

CDC42 Use in Viral Cell Entry Processes by RNA Viruses

, 2015
The cellular actin cytoskeleton presents a barrier that must be overcome by many viruses, and it has become increasingly apparent many viral species have developed a diverse repertoire of mechanisms to hijack cellular actin-regulating signalling pathways
Thomas Swaine, Matthias Dittmar, Matthias T. Dittmar   +2 more
core   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Dissecting virus entry: replication-independent analysis of virus binding, internalization, and penetration using minimal complementation of β-galactosidase. [PDF]

PLoS ONE, 2014
Studies of viral entry into host cells often rely on the detection of post-entry parameters, such as viral replication or the expression of a reporter gene, rather than on measuring entry per se. The lack of assays to easily detect the different steps of
Christine Burkard, Louis-Marie Bloyet, Oliver Wicht, Frank J van Kuppeveld, Peter J M Rottier, Cornelis A M de Haan, Berend Jan Bosch   +6 more
doaj   +1 more source