Results 31 to 40 of about 299,371 (295)
Viral entry and the ubiquitin‐proteasome system [PDF]
Cellular Microbiology, 2020 Viruses confiscate cellular components of the ubiquitin-proteasome system (UPS) to facilitate many aspects of the infectious cycle. The 26S proteasome is an ATP-dependent, multisubunit proteolytic machine present in all eukaryotic cells. The proteasome executes the controlled degradation of functional proteins, as well as the hydrolysis of aberrantly ...
Seth M. Schneider +2 more
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Virology Journal, 2018 Background Human enterovirus 71 (EV71) was previously known to enter cells through clathrin or caveolar mediated endocytic pathways. However, we observed chlorpromazine (CPZ) or dynasore (DNS), which inhibit clathrin and dynamin mediated endocytosis, did
Meichun Yuan +10 more
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Disentangling Viral Entry Kinetics Using Lipid Bilayers Coating Silica Nanoparticles
, 2020 Enveloped viruses infect cells via fusion between the viral envelope and a cellular membrane. This membrane fusion process is driven by viral proteins, but slow stochastic protein activation dominates fusion kinetics, making it challenging
Ana M., Villamil Giraldo, Peter, Kasson
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Role of lipids on entry and exit of bluetongue virus, a complex non-enveloped virus. [PDF]
, 2010 Non-enveloped viruses such as members of Picornaviridae and Reoviridae are assembled in the cytoplasm and are generally released by cell lysis. However, recent evidence suggests that some non-enveloped viruses exit from infected cells without lysis ...
Roy, Polly +3 more
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Statistical Mechanics of Viral Entry
Physical Review Letters, 2015 Viruses that have lipid-membrane envelopes infect cells by fusing with the cell membrane to release viral genes. Membrane fusion is known to be hindered by high kinetic barriers associated with drastic structural rearrangements-yet viral infection, which occurs by fusion, proceeds on remarkably short time scales.
Yaojun, Zhang, Olga K, Dudko
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Diazadispiroalkane Derivatives Are New Viral Entry Inhibitors [PDF]
Antimicrobial Agents and Chemotherapy, 2021 Herpesviruses are widespread and can cause serious illness. Many currently available antiviral drugs have limited effects, result in rapid development of resistance, and often exhibit dose-dependent toxicity.
Rebekka Adfeldt +9 more
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PLoS Pathogens, 2021 Coronavirus interaction with its viral receptor is a primary genetic determinant of host range and tissue tropism. SARS-CoV-2 utilizes ACE2 as the receptor to enter host cell in a species-specific manner.
Wenlin Ren +19 more
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A capsid-encoded PPxY-motif facilitates adenovirus entry. [PDF]
, 2010 Viruses use cellular machinery to enter and infect cells. In this study we address the cell entry mechanisms of nonenveloped adenoviruses (Ads). We show that protein VI, an internal capsid protein, is rapidly exposed after cell surface attachment and ...
Segura-Morales, Carolina +28 more
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Viral cell recognition and entry [PDF]
Protein Science, 1994 AbstractRhinovirus infection is initiated by the recognition of a specific cell‐surface receptor. The major group of rhino‐virus serotypes attach to intercellular adhesion molecule‐1 (ICAM‐1). The attachment process initiates a series of conformational changes resulting in the loss of genomic RNA from the virion.
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Ezrin interacts with the SARS coronavirus spike protein and restrains infection at the entry stage [PDF]
, 2012 © 2012 Millet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Béatrice Nal +66 more
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