Results 31 to 40 of about 488,522 (303)
Respiratory Syncytial Virus Entry Inhibitors Targeting the F Protein
Viruses, 2013 Human respiratory syncytial virus (RSV) is the main viral cause of respiratory tract infection in infants as well as some elderly and high-risk adults with chronic pulmonary disease and the severely immunocompromised.
Shibo Jiang +3 more
doaj +1 more source
Protease inhibitors targeting coronavirus and filovirus entry. [PDF]
, 2015 In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet +10 more
core +1 more source
Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. [PDF]
, 2013 The 3' untranslated region (3'UTR) of hepatitis C virus (HCV) messenger RNA stimulates viral translation by an undetermined mechanism. We identified a high affinity interaction, conserved among different HCV genotypes, between the HCV 3'UTR and the host ...
Bai, Yun +2 more
core +2 more sources
The role of cellular adhesion molecules in virus attachment and entry [PDF]
, 2015 As obligate intracellular parasites, viruses must traverse the host-cell plasma membrane to initiate infection. This presents a formidable barrier, which they have evolved diverse strategies to overcome.
Bhella, David
core +1 more source
Viral cell recognition and entry [PDF]
Protein Science, 1994 AbstractRhinovirus infection is initiated by the recognition of a specific cell‐surface receptor. The major group of rhino‐virus serotypes attach to intercellular adhesion molecule‐1 (ICAM‐1). The attachment process initiates a series of conformational changes resulting in the loss of genomic RNA from the virion.
openaire +2 more sources
PLoS Pathogens, 2021 Coronavirus interaction with its viral receptor is a primary genetic determinant of host range and tissue tropism. SARS-CoV-2 utilizes ACE2 as the receptor to enter host cell in a species-specific manner.
Wenlin Ren +19 more
doaj +1 more source
Complete replication of hepatitis C virus in cell culture. [PDF]
, 2005 Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen.
Burton, Dennis R +10 more
core +1 more source
Statistical Mechanics of Viral Entry
Physical Review Letters, 2015 Viruses that have lipid-membrane envelopes infect cells by fusing with the cell membrane to release viral genes. Membrane fusion is known to be hindered by high kinetic barriers associated with drastic structural rearrangements-yet viral infection, which occurs by fusion, proceeds on remarkably short time scales.
Yaojun, Zhang, Olga K, Dudko
openaire +3 more sources
Viral entry and the ubiquitin‐proteasome system [PDF]
Cellular Microbiology, 2020 Viruses confiscate cellular components of the ubiquitin-proteasome system (UPS) to facilitate many aspects of the infectious cycle. The 26S proteasome is an ATP-dependent, multisubunit proteolytic machine present in all eukaryotic cells. The proteasome executes the controlled degradation of functional proteins, as well as the hydrolysis of aberrantly ...
Seth M. Schneider +2 more
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PLoS Pathogens, 2021 Filoviruses, such as the Ebola virus (EBOV) and Marburg virus (MARV), are causative agents of sporadic outbreaks of hemorrhagic fevers in humans. To infect cells, filoviruses are internalized via macropinocytosis and traffic through the endosomal pathway
Corina M Stewart +10 more
doaj +1 more source