Results 41 to 50 of about 2,207,666 (298)

Viral entry glycoprotein-mediated immune evasion strategies in other viral families.

open access: yes, 2013
Viral entry glycoprotein-mediated immune evasion strategies in other viral families.
Jonathan D. Cook (586309)   +1 more
core   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad   +9 more
wiley   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko   +5 more
wiley   +1 more source

Dual-role epitope on SARS-CoV-2 spike enhances and neutralizes viral entry across different variants.

open access: yesPLoS Pathogens
Grasping the roles of epitopes in viral glycoproteins is essential for unraveling the structure and function of these proteins. Up to now, all identified epitopes have been found to either neutralize, have no effect on, or enhance viral entry into cells.
Gang Ye   +8 more
doaj   +1 more source

Building a mechanistic mathematical model of hepatitis C virus entry.

open access: yesPLoS Computational Biology, 2019
The mechanism by which hepatitis C virus (HCV) gains entry into cells is a complex one, involving a broad range of host proteins. Entry is a critical phase of the viral lifecycle, and a potential target for therapeutic or vaccine-mediated intervention ...
Mphatso Kalemera   +3 more
doaj   +1 more source

Role of Ezrin Phosphorylation in HIV-1 Replication

open access: yesFrontiers in Microbiology, 2018
Host-cell expression of the ezrin protein is required for CXCR4 (X4)-tropic HIV-1 infection. Ezrin function is regulated by phosphorylation at threonine-567. This study investigates the role of ezrin phosphorylation in HIV-1 infection and virion release.
Haruka Kamiyama   +11 more
doaj   +1 more source

Structural understanding of SARS-CoV-2 virus entry to host cells

open access: yesFrontiers in Molecular Biosciences, 2023
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of fatalities worldwide.
Kim Le   +7 more
doaj   +1 more source

Identifying Patterns of Hospitalizations Among Childhood Cancer Survivors: A Population‐Based Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood cancer survivors (CCSs) experience more hospitalizations than the general population. We aimed to identify distinct hospitalization patterns among Queensland CCSs and the associated characteristics. Methods Cases (aged ≤14 years) diagnosed between 1995 and 2019 while residents of Queensland were identified through the ...
Hai Pham   +7 more
wiley   +1 more source

Viral entry, lipid rafts and caveosomes

open access: yesAnnals of Medicine, 2005
Lipid rafts and caveolae are detergent-insoluble plasma membrane microdomains, involved in cellular endocytic processes and signalling. Several viruses, including a human pathogen, echovirus 1, and an extensively studied simian virus 40 utilize these domains for internalization into the host cells.
Vilja M, Pietiäinen   +3 more
openaire   +2 more sources

Cholesterol-rich lipid rafts mediate endocytosis as a common pathway for respiratory syncytial virus entry into different host cells

open access: yesMicrobiology Spectrum
The entry of respiratory syncytial virus (RSV) into host cells is a multifaceted process involving viral adsorption, interaction of viral glycoproteins with cellular receptors, and utilization of various invasion pathways. Despite these complexities, our
Anqi Zhou   +9 more
doaj   +1 more source

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