Results 61 to 70 of about 299,371 (295)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19

Microbiology Spectrum, 2022
The SARS-CoV-2 coronavirus, which causes COVID-19, uses a viral surface spike protein for host cell entry and the human cell-surface transmembrane serine protease, TMPRSS2, to process the spike protein.
Yuri Kosinsky, Kirill Peskov, Donald R. Stanski, Diana Wetmore, Joseph Vinetz   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Quantitative membrane proteomics reveals a role for tetraspanin enriched microdomains during entry of human cytomegalovirus. [PDF]

PLoS ONE, 2017
Human cytomegalovirus (HCMV) depends on and modulates multiple host cell membrane proteins during each stage of the viral life cycle. To gain a global view of the impact of HCMV-infection on membrane proteins, we analyzed HCMV-induced changes in the ...
Kasinath Viswanathan, Marieke C Verweij, Nessy John, Daniel Malouli, Klaus Früh   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry. [PDF]

, 2019
Viruses are a major threat to human health and economic well-being. In recent years Ebola, Zika, influenza, and chikungunya virus epidemics have raised awareness that infections can spread rapidly before vaccines or specific antagonists can be made ...
Temperton, Nigel J., Richard Angell, Imrie, Douglas, Dorner, M, Joe Grove, Farleigh, L, Michela Mazzon, Oxenford, Sally, Grove, J, Angell, R, Marcus Dorner, Farleigh, Laura, Mazzon, Michela, Wright, E, Angell, Richard, Skelton, Jessica Katy, Mark Marsh, Ana Maria Ortega-Prieto, Ortega-Prieto, AM, Jessica Katy Skelton, Dorner, Marcus, Temperton, Nigel, Wright, Edward, Michael Jacobs, Joachim J. Bugert, Nigel Temperton, Mazzon, M, Douglas Imrie, Skelton, Jessica, Ortega-Prieto, Ana Maria, Skelton, JK, Jessica Katy Skelton, Czieso, Stephanie, Oxenford, S, Hess, Lena, Ketteler, Robin, Temperton, N, Lena Hess, Stephanie Czieso, Ana Maria Ortega-Prieto, Ortega-Prieto, Ana, Jacobs, Michael, Edward Wright, Hess, L, Sally Oxenford, Luft, Christin, Jacobs, M, Bugert, JJ, Marsh, M, Christin Luft, Luft, C, Robin Ketteler, Laura Farleigh, Marsh, Mark, Grove, Joe, Czieso, S, Ketteler, R, Bugert, Joachim J, Imrie, D, Joachim J. Bugert, Bugert, Joachim   +60 more
core   +1 more source

Viral entry, lipid rafts and caveosomes

Annals of Medicine, 2005
Lipid rafts and caveolae are detergent-insoluble plasma membrane microdomains, involved in cellular endocytic processes and signalling. Several viruses, including a human pathogen, echovirus 1, and an extensively studied simian virus 40 utilize these domains for internalization into the host cells.
Vilja M, Pietiäinen, Varpu, Marjomäki, Jyrki, Heino, Timo, Hyypiä   +3 more
openaire   +2 more sources

Tetraspanins: Architects of Viral Entry and Exit Platforms [PDF]

Journal of Virology, 2019
Host factors render cells susceptible to viral infection. One family of susceptibility factors, the tetraspanin proteins, facilitate enveloped virus entry by promoting virus-cell membrane fusion.
Hantak, Michael P., Qing, Enya, Earnest, James T., Gallagher, Tom   +3 more
openaire   +2 more sources

Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses

mBio, 2018
Receptor-mediated endocytosis is a cellular process commonly hijacked by viruses to enter cells. The stages of entry are well described for certain viruses, but the host factors that mediate each step are less well characterized. We previously identified
Nicholas Rinkenberger, John W. Schoggins
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source