Results 21 to 30 of about 2,147,758 (302)

SARS-CoV-2 Spike Glycoprotein and ACE2 Interaction Reveals Modulation of Viral Entry in Wild and Domestic Animals

Frontiers in Medicine, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a viral pathogen causing life-threatening diseases in humans. Interaction between the spike protein of SARS-CoV-2 and angiotensin-converting enzyme 2 (ACE2) is a potential factor in the ...
Manas Ranjan Praharaj, Priyanka Garg, Veerbhan Kesarwani, Veerbhan Kesarwani, Neelam A. Topno, Raja Ishaq Nabi Khan, Shailesh Sharma, Manjit Panigrahi, B. P. Mishra, Bina Mishra, G. Sai Kumar, Ravi Kumar Gandham, Raj Kumar Singh, Subeer Majumdar, Trilochan Mohapatra   +14 more
doaj   +1 more source

Dominant-Negative Proteins in Herpesviruses - From Assigning Gene Function to Intracellular Immunization [PDF]

, 2009
Investigating and assigning gene functions of herpesviruses is a process, which profits from consistent technical innovation. Cloning of bacterial artificial chromosomes encoding herpesvirus genomes permits nearly unlimited possibilities in the ...
Christian A. Mohr, Ulrich Koszinowski, Mühlbach, Hermine, Koszinowski, Ulrich H., Zsolt Ruzsics, Christian Mohr, Mohr, Christian A., Ruzsics, Zsolt, Hermine Mühlbach, Ulrich H. Koszinowski   +9 more
core   +1 more source

An aquatic virus exploits the IL6-STAT3-HSP90 signaling axis to promote viral entry.

PLoS Pathogens, 2023
Viral seasonality in the aquaculture industry is an important scientific issue for decades. While the molecular mechanisms underpinning the temperature-dependent pathogenesis of aquatic viral diseases remain largely unknown.
Guoli Hou, Zhao Lv, Wenzhi Liu, Shuting Xiong, Qiushi Zhang, Chun Li, Xiaodong Wang, Liang Hu, Chunhua Ding, Rui Song, Hongquan Wang, Yong-An Zhang, Tiaoyi Xiao, Junhua Li   +13 more
doaj   +1 more source

A Mimivirus Enzyme that Participates in Viral Entry [PDF]

Structure, 2015
Mimivirus was initially identified as a bacterium because its dense, 125-nm-long fibers stained Gram-positively. These fibers probably play a role during the infection of some host cells. The normal hosts of Mimivirus are unknown, but in the laboratory Mimivirus is usually propagated in amoeba.
Klose, Thomas, Herbst, Dominik A., Zhu, Hanyu, Max, Joann P., Kenttämaa, Hilkka I., Rossmann, Michael G.   +5 more
openaire   +2 more sources

Respiratory Syncytial Virus Entry Inhibitors Targeting the F Protein

Viruses, 2013
Human respiratory syncytial virus (RSV) is the main viral cause of respiratory tract infection in infants as well as some elderly and high-risk adults with chronic pulmonary disease and the severely immunocompromised.
Shibo Jiang, Lu Lu, Zhiwu Sun, Yanbin Pan   +3 more
doaj   +1 more source

Role of lipids on entry and exit of bluetongue virus, a complex non-enveloped virus. [PDF]

, 2010
Non-enveloped viruses such as members of Picornaviridae and Reoviridae are assembled in the cytoplasm and are generally released by cell lysis. However, recent evidence suggests that some non-enveloped viruses exit from infected cells without lysis ...
Roy, Polly, Bishnupriya Bhattacharya, Bhattacharya, Bishnupriya, Polly Roy, Bhattacharya, Roy   +5 more
core   +1 more source

Enhanced human enterovirus 71 infection by endocytosis inhibitors reveals multiple entry pathways by enterovirus causing hand-foot-and-mouth diseases

Virology Journal, 2018
Background Human enterovirus 71 (EV71) was previously known to enter cells through clathrin or caveolar mediated endocytic pathways. However, we observed chlorpromazine (CPZ) or dynasore (DNS), which inhibit clathrin and dynamin mediated endocytosis, did
Meichun Yuan, Jingjing Yan, Jingna Xun, Chong Chen, Yuling Zhang, Min Wang, Wenqi Chu, Zhigang Song, Yunwen Hu, Shuye Zhang, Xiaoyan Zhang   +10 more
doaj   +1 more source

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity [PDF]

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
core   +3 more sources

Statistical Mechanics of Viral Entry

Physical Review Letters, 2015
Viruses that have lipid-membrane envelopes infect cells by fusing with the cell membrane to release viral genes. Membrane fusion is known to be hindered by high kinetic barriers associated with drastic structural rearrangements-yet viral infection, which occurs by fusion, proceeds on remarkably short time scales.
Yaojun, Zhang, Olga K, Dudko
openaire   +3 more sources

Viral cell recognition and entry [PDF]

Protein Science, 1994
AbstractRhinovirus infection is initiated by the recognition of a specific cell‐surface receptor. The major group of rhino‐virus serotypes attach to intercellular adhesion molecule‐1 (ICAM‐1). The attachment process initiates a series of conformational changes resulting in the loss of genomic RNA from the virion.
openaire   +2 more sources