Antiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry [PDF]
, 2015 Emerging viral diseases pose a threat to the global population as intervention strategies are mainly limited to basic containment due to the lack of efficacious and approved vaccines and antiviral drugs.
Temperton, Nigel J. +24 more
core +1 more source
Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent [PDF]
, 2011 Herpes simplex virus type 1 (HSV-1) can enter cells via endocytic pathways or direct fusion at the plasma membrane depending on the cell line and receptor(s).
Mei-Ju Hsu +16 more
core +1 more source
Viral entry mechanisms: the increasing diversity of paramyxovirus entry [PDF]
The FEBS Journal, 2009 The paramyxovirus family contains established human pathogens such as the measles virus and human respiratory syncytial virus, as well as emerging pathogens including the Hendra and Nipah viruses and the recently identified human metapneumovirus. Two major envelope glycoproteins, the attachment protein and the fusion protein, promote the processes of ...
Everett C, Smith +4 more
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Caveolin-1 associated adenovirus entry into human corneal cells. [PDF]
PLoS ONE, 2013 The cellular entry of viruses represents a critical area of study, not only for viral tropism, but also because viral entry dictates the nature of the immune response elicited upon infection.
Mohammad A Yousuf +7 more
doaj +1 more source
Single-Virus Microscopy of Biochemical Events in Viral Entry [PDF]
Jacs AuSteinar Mannsverk +2 more
exaly +2 more sources
Coxsackievirus B3 Activates Macrophages Independently of CAR-Mediated Viral Entry. [PDF]
VirusesEnteroviruses are a genus of small RNA viruses that are responsible for approximately one billion global infections annually. These infections range in severity from the common cold and flu-like symptoms to more severe diseases, such as viral myocarditis,
Mohamud Y +5 more
europepmc +2 more sources
Non-viral approaches to gene therapy [PDF]
, 1993 Several advances in non-viral gene transfer technology have been reported over the past year. Cationic lipids have been successfully used to deliver genes in vivo, providing a clear alternative to recombinant viruses.
Wagner, Ernst, Cotten, Matt
core +1 more source
Respiratory Syncytial Virus Entry Inhibitors Targeting the F Protein
Viruses, 2013 Human respiratory syncytial virus (RSV) is the main viral cause of respiratory tract infection in infants as well as some elderly and high-risk adults with chronic pulmonary disease and the severely immunocompromised.
Shibo Jiang +3 more
doaj +1 more source
Dominant-Negative Proteins in Herpesviruses - From Assigning Gene Function to Intracellular Immunization [PDF]
, 2009 Investigating and assigning gene functions of herpesviruses is a process, which profits from consistent technical innovation. Cloning of bacterial artificial chromosomes encoding herpesvirus genomes permits nearly unlimited possibilities in the ...
Christian A. Mohr +9 more
core +1 more source
A Mimivirus Enzyme that Participates in Viral Entry [PDF]
Structure, 2015 Mimivirus was initially identified as a bacterium because its dense, 125-nm-long fibers stained Gram-positively. These fibers probably play a role during the infection of some host cells. The normal hosts of Mimivirus are unknown, but in the laboratory Mimivirus is usually propagated in amoeba.
Klose, Thomas +5 more
openaire +2 more sources