Results 11 to 20 of about 488,522 (303)
Membrane Rafts: Portals for Viral Entry [PDF]
Frontiers in Microbiology, 2021 Membrane rafts are dynamic, small (10–200 nm) domains enriched with cholesterol and sphingolipids that compartmentalize cellular processes. Rafts participate in roles essential to the lifecycle of different viral families including virus entry, assembly ...
Inés Ripa +7 more
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Virus Research, 2012 Virus infection of host cells requires that entry into the cell results in efficient genome release leading to translation and replication. These initial steps revolving around the entry and genomic release processes are crucial for viral progeny generation.
Angela, Vázquez-Calvo +4 more
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Membranotropic peptides mediating viral entry [PDF]
Peptide Science, 2018 AbstractThe means used by enveloped viruses to bypass cellular membranes are well characterized; however, the mechanisms used by non‐enveloped viruses to deliver their genome inside the cell remain unresolved and poorly defined. The discovery of short, membrane interacting, amphipathic or hydrophobic sequences (known as membranotropic peptides) in both
Falanga, Annarita +3 more
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Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration
eLife, 2020 The Spike protein of SARS-CoV-2, its receptor-binding domain (RBD), and its primary receptor ACE2 are extensively glycosylated. The impact of this post-translational modification on viral entry is yet unestablished.
Qi Yang +8 more
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Diazadispiroalkane Derivatives Are New Viral Entry Inhibitors [PDF]
Antimicrobial Agents and Chemotherapy, 2021 Herpesviruses are widespread and can cause serious illness. Many currently available antiviral drugs have limited effects, result in rapid development of resistance, and often exhibit dose-dependent toxicity.
Rebekka Adfeldt +9 more
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Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry [PDF]
The FEBS Journal, 2009 Herpes simplex virus type‐1 and type‐2 are highly prevalent human pathogens causing life‐long infections. The process of infection begins when the virions bind heparan sulfate moieties present on host cell surfaces. This initial attachment then triggers a cascade of molecular interactions involving multiple viral and host cell proteins and receptors ...
Jihan, Akhtar, Deepak, Shukla
openaire +2 more sources
Viruses, 2020 Viral entry is the first stage in the virus replication cycle and, for enveloped viruses, is mediated by virally encoded glycoproteins. Viral glycoproteins have different receptor affinities and triggering mechanisms.
Maria Fernanda Lay Mendoza +4 more
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Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. [PDF]
, 2011 Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged as the causal agent of an endemic atypical pneumonia, infecting thousands of people worldwide.
Agudelo, Juliet +10 more
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Frontiers in Medicine, 2022 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a viral pathogen causing life-threatening diseases in humans. Interaction between the spike protein of SARS-CoV-2 and angiotensin-converting enzyme 2 (ACE2) is a potential factor in the ...
Manas Ranjan Praharaj +14 more
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Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection. [PDF]
, 2018 Innate immune cells quickly infiltrate the site of pathogen entry and not only stave off infection but also initiate antigen presentation and promote adaptive immunity.
A Gladiator +75 more
core +3 more sources