Results 21 to 30 of about 2,656,206 (255)
A capsid-encoded PPxY-motif facilitates adenovirus entry. [PDF]
, 2010 Viruses use cellular machinery to enter and infect cells. In this study we address the cell entry mechanisms of nonenveloped adenoviruses (Ads). We show that protein VI, an internal capsid protein, is rapidly exposed after cell surface attachment and ...
Segura-Morales, Carolina +28 more
core +1 more source
Exploiting Herpes Simplex Virus Entry for Novel Therapeutics
Viruses, 2013 Herpes Simplex virus (HSV) is associated with a variety of diseases such as genital herpes and numerous ocular diseases. At the global level, high prevalence of individuals who are seropositive for HSV, combined with its inconspicuous infection, remains ...
Deepak Shukla, Satvik Hadigal
doaj +1 more source
HCMV spread and cell tropism are determined by distinct virus populations. [PDF]
, 2011 Human cytomegalovirus (HCMV) can infect many different cell types in vivo. Two gH/gL complexes are used for entry into cells. gH/gL/pUL(128,130,131A) shows no selectivity for its host cell, whereas formation of a gH/gL/gO complex only restricts the ...
Ulrich H Koszinowski +10 more
core +2 more sources
Ezrin interacts with the SARS coronavirus spike protein and restrains infection at the entry stage [PDF]
, 2012 © 2012 Millet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Béatrice Nal +66 more
core +1 more source
Identification of Diaryl-Quinoline Compounds as Entry Inhibitors of Ebola Virus
Viruses, 2018 Ebola virus is the causative agent of Ebola virus disease in humans. The lethality of Ebola virus infection is about 50%, supporting the urgent need to develop anti-Ebola drugs.
Qinghua Cui +7 more
doaj +1 more source
Cells, 2021 Research on infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is currently restricted to BSL-3 laboratories. SARS-CoV2 virus-like particles (VLPs) offer a BSL-1, replication-incompetent system that can be used to evaluate virus ...
Binod Kumar +5 more
doaj +1 more source
Vaccinia Virus Infection Requires Maturation of Macropinosomes. [PDF]
, 2015 The prototypic poxvirus, vaccinia virus (VACV), occurs in two infectious forms, mature virions (MVs) and extracellular virions (EVs). Both enter HeLa cells by inducing macropinocytic uptake.
Mercer, Jason +13 more
core +1 more source
Phosphoinositide-3 kinase-Akt pathway controls cellular entry of Ebola virus.
PLoS Pathogens, 2008 The phosphoinositide-3 kinase (PI3K) pathway regulates diverse cellular activities related to cell growth, migration, survival, and vesicular trafficking. It is known that Ebola virus requires endocytosis to establish an infection.
Mohammad F Saeed +4 more
doaj +1 more source
Viruses, 2023 Many viruses attach to host cells by first interacting with cell surface proteoglycans containing heparan sulfate (HS) glycosaminoglycan chains and then by engaging with specific receptor, resulting in virus entry.
Poonam Sharma +5 more
doaj +1 more source
Identification and characterization of a novel non-structural protein of bluetongue virus [PDF]
, 2011 Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue). For over two decades, it has been widely accepted that the 10 segments of the dsRNA genome of BTV encode for 7 structural and 3 non-structural proteins.
Rixon, F. +43 more
core +1 more source