Results 41 to 50 of about 262,059 (309)

Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity [PDF]

, 2013
Foot-and-mouth disease virus (FMDV) is a significant economically and distributed globally pathogen of Artiodactyla. Current vaccines are chemically inactivated whole virus particles that require large-scale virus growth in strict bio-containment with ...
Owens, Ray, Paramasivam, S, Kotecha, A, Wilsden, G, Parida, Satya, Paton, David, Ren, Junyuan, Al-Khalil, Tara, Belsham, Graham J., Lomonossoff, GP, Li, Yanmin, Belsham, GJ, Loureiro, S, Kotecha, Abhay, Belsham, Graham, Owens, R, Stuart, David I, Lomonossoff, George P., Porta, C, Xu, X, Parida, S, Lomonossoff, George P, Burman, Alison, Paton, D, Jones, IM, Curry, S, Blesham, Graham J., Paramasivam, Saravanan, Xu, Xiaodong, Stuart, DI, Charleston, Bryan, Jackson, T, Charleston, B, Burman, A, Jones, Ian M., Porta, Claudine, Ren, J, Stuart, David I., Fry, E, Stuart, David, Jones, Ian M, Ferris, N, Ferris, Nigel, Loureiro, Silvia, Belsham, Graham J, Curry, Stephen, Jackson, Terry, Al-Khalil, T, Li, Y, Fry, Elizabeth, Wilsden, Ginette   +50 more
core   +1 more source

CryoEM of Viral Ribonucleoproteins and Nucleocapsids of Single-Stranded RNA Viruses

Viruses, 2023
Single-stranded RNA viruses (ssRNAv) are characterized by their biological diversity and great adaptability to different hosts; traits which make them a major threat to human health due to their potential to cause zoonotic outbreaks.
Andrea Modrego, Diego Carlero, Rocío Arranz, Jaime Martín-Benito   +3 more
doaj   +1 more source

Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the Virion Glycome [PDF]

, 2014
Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins.
Scrivens, JH, Crispin, Max, Huiskonen, JT, Scrivens, James H., Bitto, David, Crispin, Matthew, Harvey, David J, Bitto, D, Scrivens, James, Huiskonen, Juha T, Bowden, Thomas A, Crispin, M, Bowden, Thomas A., Scrivens, James H, Edgeworth, Matthew, Halldorsson, Steinar, Huiskonen, Juha T., Bonomelli, Camille, Edgeworth, M, Bowden, TA, Bonomelli, C, Harvey, David J., Harvey, DJ, Halldorsson, S   +23 more
core   +1 more source

Physical Virology in Spain

Biophysica, 2023
Virus particles consist of a protein coat that protects their genetic material and delivers it to the host cell for self-replication. Understanding the interplay between virus structure and function is a requirement for understanding critical processes ...
David Reguera, Pedro J. de Pablo, Nicola G. A. Abrescia, Mauricio G. Mateu, Javier Hernández-Rojas, José R. Castón, Carmen San Martín   +6 more
doaj   +1 more source

Role of nonstructural protein NS2A in flavivirus assembly

, 2008
Flavivirus nonstructural (NS) proteins are involved in RNA replication and modulation of the host antiviral response; however, evidence is mounting that some NS proteins also have essential roles in virus assembly.
Pijlman, G.P., Leung, J.Y., Khromykh, A.A., Hyde, J., Kondratieva, N., Mackenzie, J.M.   +5 more
core   +1 more source

Zika Virus NS2A-Mediated Virion Assembly

mBio, 2019
The flavivirus virion consists of an envelope outer layer, formed by envelope (E) and membrane (M) proteins on a lipid bilayer, and an internal core, formed by capsid (C) protein and genomic RNA. The molecular mechanism of flavivirus assembly is not well
Xianwen Zhang, Xuping Xie, Hongjie Xia, Jing Zou, Linfen Huang, Vsevolod L. Popov, Xinwen Chen, Pei-Yong Shi   +7 more
doaj   +1 more source

Cryotomography of budding influenza a virus reveals filaments with diverse morphologies that mostly do not bear a genome at their distal end [PDF]

, 2013
Influenza viruses exhibit striking variations in particle morphology between strains. Clinical isolates of influenza A virus have been shown to produce long filamentous particles while laboratory-adapted strains are predominantly spherical.
Swetha Vijayakrishnan, Vijayakrishnan Swetha, Jackson David, Worawit Suphamungmee, David Bhella, Loney Colin, Bhella, D., Swetha Vijayakrishnan (418947), Colin Loney (418948), David Jackson (84936), Frazer J. Rixon (129686), Colin Loney, Suphamungmee Worawit, Rixon, F.J., Jackson, David, Worawit Suphamungmee (418949), Rixon Frazer J., Vijayakrishnan, Swetha, Rixon, Frazer J., Loney, Colin, Bhella David, David Jackson, Loney, C., Suphamungmee, W., Jackson, D., Bhella, David, Vijayakrishnan, S., David Bhella (129684), Suphamungmee, Worawit, Frazer J Rixon   +29 more
core   +1 more source

ASFV pE146L-induced ER remodeling is essential for viral replication

Journal of Virology
African swine fever virus (ASFV) causes a severe hemorrhagic disease, posing a significant threat to the global pig industry. Although the ASFV encodes nearly 200 proteins, the functions of many remain unknown.
Yilin Guo, Sai Niu, Xueying Wang, Zixuan Wang, Rui Liang, Yubei Tan, Zhen Fu, Zhelin Su, Juan Xu, Hongjun Chen, Yuejun Shi, Limeng Sun, Guiqing Peng   +12 more
doaj   +1 more source

An Alphavirus E2 Membrane-Proximal Domain Promotes Envelope Protein Lateral Interactions and Virus Budding

mBio, 2017
Alphaviruses are members of a group of small enveloped RNA viruses that includes important human pathogens such as Chikungunya virus and the equine encephalitis viruses.
Emily A. Byrd, Margaret Kielian
doaj   +1 more source

Super-resolution microscopy reveals specific recruitment of HIV-1 envelope proteins to viral assembly sites dependent on the envelope C-terminal tail

, 2013
The inner structural Gag proteins and the envelope (Env) glycoproteins of human immunodeficiency virus (HIV-1) traffic independently to the plasma membrane, where they assemble the nascent virion. HIV-1 carries a relatively low number of glycoproteins in
Mike Heilemann, Barbara Müller, Walter Muranyi (212637), Malkusch, Sebastian, Müller, Barbara, Hans-Georg Kräusslich (7273), Walter Muranyi, Mike Heilemann (162287), Barbara Müller (212640), Sebastian Malkusch (383895), Muranyi, Walter, Hans-Georg Kräusslich, Kräusslich, Hans-Georg, Sebastian Malkusch, Heilemann, Mike   +14 more
core   +1 more source