Results 61 to 70 of about 262,059 (309)

Assembly and budding of influenza virus

Virus Research, 2004
Influenza viruses are causative agents of an acute febrile respiratory disease called influenza (commonly known as "flu") and belong to the Orthomyxoviridae family. These viruses possess segmented, negative stranded RNA genomes (vRNA) and are enveloped, usually spherical and bud from the plasma membrane (more specifically, the apical plasma membrane of
Nayak, Debi P, Hui, Eric Ka-Wai, Barman, Subrata   +2 more
openaire   +4 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The structural basis for the integrity of adenovirus Ad3 dodecahedron [PDF]

, 2012
During the viral life cycle adenoviruses produce excess capsid proteins. Human adenovirus serotype 3 (Ad3) synthesizes predominantly an excess of free pentons, the complexes of pentameric penton base and trimeric fiber proteins, which are responsible for
Fender, Pascal, Monika Zochowska (134637), Jean-Pierre Andrieu, Ewa Szolajska (134629), Stephen Cusack (134664), Burmeister, Wim P, Pascal Fender (132764), Szolajska, Ewa, Pascal Fender, Nerlo, Barbara, Burmeister, Wim P., Igor Andreev, Wim P. Burmeister (134634), Wim P Burmeister, Guy Schoehn, Jadwiga Chroboczek (134668), Andreev, Igor, Naskalska, Antonina, Stephen Cusack, Chroboczek, Jadwiga, Barbara Nerlo (134643), Ewa Szolajska, Chloe Zubieta (134662), Barbara Nerlo, Igor Andreev (134649), Andrieu, Jean-Pierre, Jadwiga Chroboczek, Chloe Zubieta, Monika Zochowska, Zochowska, Monika, Cusack, Stephen, Jean-Pierre Andrieu (134655), Schoehn, Guy, Antonina Naskalska, Guy Schoehn (27525), Zubieta, Chloe, Antonina Naskalska (134660)   +36 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Cryo-EM structure in situ reveals a molecular switch that safeguards virus against genome loss

eLife, 2020
The portal protein is a key component of many double-stranded DNA viruses, governing capsid assembly and genome packaging. Twelve subunits of the portal protein define a tunnel, through which DNA is translocated into the capsid.
Oliver W Bayfield, Alasdair C Steven, Alfred A Antson   +2 more
doaj   +1 more source

Ab initio modeling of the herpesvirus VP26 core domain assessed by CryoEM density [PDF]

, 2006
Efforts in structural biology have targeted the systematic determination of all protein structures through experimental determination or modeling.
Baker, David, Rixon Frazer J, Baker David, Wedemeyer, W.J., Matthew L Baker, Jiang Wen, Chiu Wah, Baker, M.L., Chiu, Wah, Wah Chiu, Jiang, W., Baker, D., Chiu, W., Baker, Matthew L, Wedemeyer, William J, Rixon, Frazer J, Jiang, Wen, Baker Matthew L, Frazer J Rixon, Rixon, F.J., William J Wedemeyer, David Baker, Wedemeyer William J, Wen Jiang   +23 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Genetic modification of Bluetongue virus by uptake of "synthetic" genome segments [PDF]

, 2010
Since 1998, several serotypes of Bluetongue virus (BTV) have invaded several southern European countries. In 2006, the unknown BTV serotype 8 (BTV8/net06) unexpectedly invaded North-West Europe and has resulted in the largest BT-outbreak ever recorded ...
Veldman, D., van de Water, S.G.P., René GP van Gennip, van de Water Sandra GP, Veldman Daniel, Piet A van Rijn, Rijn, P.A., van, Daniel Veldman, van Gennip, H.G.P., Gennip, H.G.P., van, van Gennip René GP, van Rijn Piet A, Water, S.G.P., van de, Sandra GP van de Water, van Rijn, P.A.   +14 more
core   +1 more source

Virus assembly: Imaging a molecular machine [PDF]

Current Biology, 1999
A recent structural study of a double-stranded DNA bacteriophage has provided remarkable new insights into the assembly of a complex virus particle and ushers in a new era in the imaging of non-icosahedral viruses.
Wikoff, William R., Johnson, John E.
openaire   +2 more sources