Effects of reduced gag cleavage efficiency on HIV-1 Gag-Pol package
BMC Microbiology, 2022 Background HIV-1 pol, which encodes enzymes required for virus replication, is initially translated as a Gag-Pol fusion protein. Gag-Pol is incorporated into virions via interactions with Gag precursor Pr55 gag .
Yi-Ru Lin +4 more
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Dynamics of HIV-1 assembly and release. [PDF]
, 2009 Assembly and release of human immunodeficiency virus (HIV) occur at the plasma membrane of infected cells and are driven by the Gag polyprotein. Previous studies analyzed viral morphogenesis using biochemical methods and static images, while dynamic and ...
Kräusslich Hans-Georg +28 more
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Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles [PDF]
, 2006 Includes bibliographical references (leaves 114-128).In this study I explored the possibility of making HIV-1 subtype C Pr55gag-based chimaeric virus-like particles (VLPs) as a boost to the HIV-IC multigene DNA vaccine pTHr.grttnC, which encodes a ...
Halsey, Richard James
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The role of the HIV-1 protease substrate in therapy resistance [PDF]
, 2015 In Switzerland and Germany up to a half of the first-line regimens include protease inhibitors (PIs) [1, 2]. Although in the Swiss HIV Cohort Study (SHCS) most patients under antiretroviral therapy (ART) have suppressed viral loads [3], every third ...
Kletenkov, Konstantin
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Delivering the second revolution in site-specific nucleases
eLife, 2014 Viruses have been used to deliver two types of site-specific nucleases into cells for targeted gene editing.
Perry B Hackett, Nikunj V Somia
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Priming with a recombinant pantothenate auxotroph of Mycobacterium bovis BCG and boosting with MVA elicits HIV-1 Gag specific CD8+ T cells. [PDF]
PLoS ONE, 2012 A safe and effective HIV vaccine is required to significantly reduce the number of people becoming infected with HIV each year. In this study wild type Mycobacterium bovis BCG Pasteur and an attenuated pantothenate auxotroph strain (BCGΔpanCD) that is ...
Rosamund Chapman +8 more
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Veterinary Sciences, 2016 Feline immunodeficiency virus (FIV) infection results in viral persistence, a prolonged asymptomatic phase, and progressive immunopathology. During the asymptomatic phase, a cohort of experimentally FIV-infected cats exhibits features of viral latency in
Christina D. Eckstrand +2 more
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Protease mediated maturation of HIV: Inhibitors of protease and the maturation process [PDF]
, 2012 Protease-mediated maturation of HIV-1 virus particles is essential for virus infectivity. Maturation occurs concomitant with immature virus particle release and is mediated by the viral protease (PR), which sequentially cleaves the Gag and Gag-Pol ...
Catherine S. Adamson +1 more
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HIV protein profile characteristics in patients with first-time detected infection
Инфекция и иммунитетThe HIV-infection continues to be one of the most large-scale epidemics worldwide. Many techniques have been developed to detect this disease, but the Western blot based on the identification of specific viral proteins remains the most commonly used ...
V. S. Davydenko +4 more
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Full length HIV-1 Gag determines protease inhibitor susceptibility within in vitro assays [PDF]
, 2010 OBJECTIVE: There is evidence that gag contributes to protease inhibitor susceptibility in treatment-experienced patients. Moreover, protease inhibitor resistance-associated mutations can arise in gag in the absence of protease mutations in vitro.
Gupta, R.K. +5 more
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