Gag-Gag Interactions Are Insufficient to Fully Stabilize and Order the Immature HIV Gag Lattice [PDF]
Viruses, 2021 Immature HIV virions harbor a lattice of Gag molecules with significant ordering in CA-NTD, CA-CTD and SP1 regions. This ordering plays a major role during HIV maturation. To test the condition in which the Gag lattice forms in vivo, we assembled virus like particles (VLPs) by expressing only HIV Gag in mammalian cells.
Ipsita Saha +8 more
openaire +3 more sources
Long Terminal Repeats Region as a Potential Target for HIV Molecular Detection
Makara Journal of Health Research, 2011 Indonesian National Committee for human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) has reported the significant increase of HIV infected individual in Indonesia.
Aroem Naroeni +3 more
doaj +1 more source
Effects of reduced gag cleavage efficiency on HIV-1 Gag-Pol package
BMC Microbiology, 2022 Background HIV-1 pol, which encodes enzymes required for virus replication, is initially translated as a Gag-Pol fusion protein. Gag-Pol is incorporated into virions via interactions with Gag precursor Pr55 gag .
Yi-Ru Lin +4 more
doaj +1 more source
Priming with a recombinant pantothenate auxotroph of Mycobacterium bovis BCG and boosting with MVA elicits HIV-1 Gag specific CD8+ T cells. [PDF]
PLoS ONE, 2012 A safe and effective HIV vaccine is required to significantly reduce the number of people becoming infected with HIV each year. In this study wild type Mycobacterium bovis BCG Pasteur and an attenuated pantothenate auxotroph strain (BCGΔpanCD) that is ...
Rosamund Chapman +8 more
doaj +1 more source
Delivering the second revolution in site-specific nucleases
eLife, 2014 Viruses have been used to deliver two types of site-specific nucleases into cells for targeted gene editing.
Perry B Hackett, Nikunj V Somia
doaj +1 more source
HIV protein profile characteristics in patients with first-time detected infection
Инфекция и иммунитетThe HIV-infection continues to be one of the most large-scale epidemics worldwide. Many techniques have been developed to detect this disease, but the Western blot based on the identification of specific viral proteins remains the most commonly used ...
V. S. Davydenko +4 more
doaj +1 more source
The HIV-1 late domain-2 S40A polymorphism in antiretroviral (or ART)-exposed individuals influences protease inhibitor susceptibility. [PDF]
, 2016 BackgroundThe p6 region of the HIV-1 structural precursor polyprotein, Gag, contains two motifs, P7TAP11 and L35YPLXSL41, designated as late (L) domain-1 and -2, respectively.
Anastos, Kathryn +14 more
core +1 more source
HIV Research & Clinical Practice, 2019 To understand the pathogenesis of low level viraemia (LLV) in HIV-infected patients on boosted protease inhibitors (PI/b), we enrolled 34 subjects with a median HIV-RNA 79 copies/mL and followed them for 15 months.
Francesca Ferretti +7 more
doaj +1 more source
A novel minimal in vitro system for analyzing HIV-1 Gag mediated budding
, 2014 A biomimetic minimalist model membrane was used to study the mechanism and kinetics of cell-free in vitro HIV-1 Gag budding from a giant unilamellar vesicle (GUV).
Gill, Sarjeet +7 more
core +1 more source
DNA gag/Adenovirus Type 5 (Ad5) gag and Ad5 gag/Ad5 gag Vaccines Induce Distinct T-Cell Response Profiles [PDF]
Journal of Virology, 2008 ABSTRACT Results from Merck's phase II adenovirus type 5 (Ad5) gag/pol/nef test-of-concept trial showed that the vaccine lacked efficacy against human immunodeficiency virus (HIV) infection in a high-risk population.
Kara S, Cox +7 more
openaire +2 more sources