Results 21 to 30 of about 186,106 (305)

Long Terminal Repeats Region as a Potential Target for HIV Molecular Detection

Makara Journal of Health Research, 2011
Indonesian National Committee for human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) has reported the significant increase of HIV infected individual in Indonesia.
Aroem Naroeni, Hatiyowidi Yuliawuri, Fera Ibrahim, Budiman Bela   +3 more
doaj   +1 more source

Effects of reduced gag cleavage efficiency on HIV-1 Gag-Pol package

BMC Microbiology, 2022
Background HIV-1 pol, which encodes enzymes required for virus replication, is initially translated as a Gag-Pol fusion protein. Gag-Pol is incorporated into virions via interactions with Gag precursor Pr55 gag .
Yi-Ru Lin, Shih-Ming Chu, Fu-Hsien Yu, Kuo-Jung Huang, Chin-Tien Wang   +4 more
doaj   +1 more source

Dynamics of HIV-1 assembly and release. [PDF]

, 2009
Assembly and release of human immunodeficiency virus (HIV) occur at the plasma membrane of infected cells and are driven by the Gag polyprotein. Previous studies analyzed viral morphogenesis using biochemical methods and static images, while dynamic and ...
Kräusslich Hans-Georg, Barbara Müller, William J. Godinez, Bräuchle Christoph, Müller, Barbara, Rohr Karl, Karl Rohr, Godinez, William J., William J Godinez, Lampe Marko, Eils, Roland, Godinez William J., Roland Eils, Rohr, Karl, Lampe, Marko, Ivanchenko Sergey, Lamb, Don C., Don C. Lamb, Marko Lampe, Bräuchle, Christoph, Eils Roland, Lamb Don C., Hans-Georg Kräusslich, Christoph Bräuchle, Kräusslich, Hans-Georg, Sergey Ivanchenko, Ivanchenko, Sergey, Don C Lamb, Müller Barbara   +28 more
core   +2 more sources

Full length HIV-1 Gag determines protease inhibitor susceptibility within in vitro assays [PDF]

, 2010
OBJECTIVE: There is evidence that gag contributes to protease inhibitor susceptibility in treatment-experienced patients. Moreover, protease inhibitor resistance-associated mutations can arise in gag in the absence of protease mutations in vitro.
Gupta, R.K., Pillay, D., Towers, G.J., Kohli, A., Parry, C.M., McCormick, A.L.   +5 more
core   +1 more source

Priming with a recombinant pantothenate auxotroph of Mycobacterium bovis BCG and boosting with MVA elicits HIV-1 Gag specific CD8+ T cells. [PDF]

PLoS ONE, 2012
A safe and effective HIV vaccine is required to significantly reduce the number of people becoming infected with HIV each year. In this study wild type Mycobacterium bovis BCG Pasteur and an attenuated pantothenate auxotroph strain (BCGΔpanCD) that is ...
Rosamund Chapman, Enid Shephard, Helen Stutz, Nicola Douglass, Vasan Sambandamurthy, Irene Garcia, Bernhard Ryffel, William Jacobs, Anna-Lise Williamson   +8 more
doaj   +1 more source

Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses [PDF]

, 2000
The immune response to HIV-1 in patients who carry human histocompatibility leukocyte antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (amino acids 263-272, KR WIILGLNK).
Anthony D. Kelleher, Jamie Wilson, Wayne Dyer, Sunil Shaunak, Sullivan, JS, Ian Jones, Workman, C, Rodney E. Phillips, Edward C. Holmes, Kelleher, AD, Christopher Conlon, Rachel L. Allen, John S. Sullivan, Conlon, C, Shaunak, S, Christian Brander, Kara Olson, Allen, RL, Dyer, W, Olson, K, Graham Ogg, Brander, C, Philip Goulder, Ogg, G, Andrew J. McMichael, Long, C, Holmes, EC, Wilson, J, Goulder, P, Cassy Workman, Sarah Rowland-Jones, Rowland-Jones, S, McMichael, AJ, Jones, I, Phillips, RE, Chad Long   +35 more
core   +1 more source

Delivering the second revolution in site-specific nucleases

eLife, 2014
Viruses have been used to deliver two types of site-specific nucleases into cells for targeted gene editing.
Perry B Hackett, Nikunj V Somia
doaj   +1 more source

The role of the HIV-1 protease substrate in therapy resistance [PDF]

, 2015
In Switzerland and Germany up to a half of the first-line regimens include protease inhibitors (PIs) [1, 2]. Although in the Swiss HIV Cohort Study (SHCS) most patients under antiretroviral therapy (ART) have suppressed viral loads [3], every third ...
Kletenkov, Konstantin
core   +1 more source

Sequence Instability in the Proviral Long Terminal Repeat and gag Regions from Peripheral Blood and Tissue-Derived Leukocytes of FIV-Infected Cats during the Late Asymptomatic Phase

Veterinary Sciences, 2016
Feline immunodeficiency virus (FIV) infection results in viral persistence, a prolonged asymptomatic phase, and progressive immunopathology. During the asymptomatic phase, a cohort of experimentally FIV-infected cats exhibits features of viral latency in
Christina D. Eckstrand, Chadwick Hillman, Brian G. Murphy   +2 more
doaj   +1 more source

HIV protein profile characteristics in patients with first-time detected infection

Инфекция и иммунитет
The HIV-infection continues to be one of the most large-scale epidemics worldwide. Many techniques have been developed to detect this disease, but the Western blot based on the identification of specific viral proteins remains the most commonly used ...
V. S. Davydenko, Yuliia V. Ostankova, A. N. Schemelev, E. N. Serikova, A. A. Totolian   +4 more
doaj   +1 more source