Results 1 to 10 of about 93,005 (292)
Incorporation of chimeric HIV-SIV-Env and modified HIV-Env proteins into HIV pseudovirions [PDF]
Virology, 2007 Low level incorporation of the viral glycoprotein (Env) into human immunodeficiency virus (HIV) particles is a major drawback for vaccine strategies against HIV/AIDS in which HIV particles are used as immunogen. Within this study, we have examined two strategies aimed at achieving higher levels of Env incorporation into non-infectious pseudovirions ...
Valerie Bosch, Tanya Pfeiffer
exaly +4 more sources
Immunogenicity of HIV-1 Env mRNA and Env-Gag VLP mRNA Vaccines in Mice
VaccinesBackground: The development of a protective vaccine is critical for conclusively ending the human immunodeficiency virus (HIV) epidemic. Methods: We constructed nucleotide-modified mRNA vaccines expressing HIV-1 Env and Gag proteins.
Qi Ma +5 more
doaj +4 more sources
Env Exceptionalism: Why Are HIV-1 Env Glycoproteins Atypical Immunogens? [PDF]
Cell Host and Microbe, 2020 Recombinant HIV-1 envelope (Env) glycoproteins of ever-increasing sophistication have been evaluated as vaccine candidates for over 30 years. Structurally defined mimics of native trimeric Env glycoproteins (e.g., SOSIP trimers) present multiple epitopes for broadly neutralizing antibodies (bNAbs) and their germline precursors, but elicitation of bNAbs
Per Johan Klasse +2 more
exaly +5 more sources
Endocytic motif on HIV-1 Env regulates cleavage status and antibody neutralization of cell-free and cell-to-cell infection [PDF]
Journal of VirologyEndocytic recycling regulates the abundance of human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) on the cell surface, where Env comprises both cleaved and uncleaved forms.
Dania M. Figueroa Acosta +3 more
doaj +2 more sources
مجله دانشکده پزشکی اصفهان, 2021 Background: Breast cancer is one of the most common malignancies in women worldwide. Global Cancer Observatory (GLOBOCAN) data for 2019 show that about two million women are diagnosed with breast cancer each year. Human endogenous retroviruses (HERV) can
Mahdiyeh Miralimalek +4 more
doaj +1 more source
DISTINCTIVE SIRE1 RETROTRANSPOSON PATTERNS ON BARLEY CHROMOSOMES?
Trakya University Journal of Natural Sciences, 2021 SIRE1 is an active and relatively high copy-number retroelement belongs to the Tyl/Copia long terminal repeat (LTR) retrotransposon superfamily. Distinctive SIRE1 elements (ENV and GAG) distributions in barley genome were observed by using fluorescent in
Nermin Gozukirmizi, Elif Karlık
doaj +1 more source
SPATIOTEMPORAL FUSION OF HIGH RESOLUTION LAND SURFACE TEMPERATURE USING THERMAL SHARPENED IMAGES FROM REGRESSION-BASED URBAN INDICES [PDF]
ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2020 Obtaining spatially continuous, high resolution thermal images is crucial in order to effectively analyze heat-related phenomena in urban areas and the inherent high spatial and temporal variations.
M. Kim, K. Cho, H. Kim, Y. Kim
doaj +1 more source
Virulence, 2021 Avian leukosis virus subgroup J (ALV-J) generally induces hemangioma, myeloid leukosis, and immunosuppression in chickens, causing significant poultry industry economic losses worldwide. The unusual env gene of ALV-J, with low homology to other subgroups
Tuofan Li +10 more
doaj +1 more source
Additional ORFs in Plant LTR-Retrotransposons
Frontiers in Plant Science, 2020 LTR-retrotransposons share a common genomic organization in which the 5′ long terminal repeat (LTR) is followed by the gag and pol genes and terminates with the 3′ LTR.
Carlos M. Vicient, Josep M. Casacuberta
doaj +1 more source
Large scale Vertical SEALing (VSEAL) test: Impact of gas migration on bentonite based vertical seals [PDF]
E3S Web of Conferences, 2023 The Institute for Radiological protection and Nuclear Safety (IRSN) has launched the VSEAL project to investigate the impact of gas migration on the long-term performance of bentonite based vertical sealing systems.
Mokni Nadia +2 more
doaj +1 more source