Results 51 to 60 of about 186,106 (305)

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice [PDF]

, 2008
Includes abstract.Includes bibliographical references (leaves 139-148).The devastating effect the HIV pandemic has had on the human population in the last twenty five years has highlighted the great need to develop a prophylactic HIV vaccine.
Pillay, Sirika
core   +1 more source

Investigation of HIV-1 Gag binding with RNAs and lipids using Atomic Force Microscopy.

PLoS ONE, 2020
Atomic Force Microscopy was utilized to study the morphology of Gag, ΨRNA, and their binding complexes with lipids in a solution environment with 0.1Å vertical and 1nm lateral resolution. TARpolyA RNA was used as a RNA control. The lipid used was phospha-
Shaolong Chen, Jun Xu, Mingyue Liu, A L N Rao, Roya Zandi, Sarjeet S Gill, Umar Mohideen   +6 more
doaj   +1 more source

Placement of leucine zipper motifs at the carboxyl terminus of HIV-1 protease significantly reduces virion production. [PDF]

PLoS ONE, 2012
Natural HIV-1 protease (PR) is homodimeric. Some researchers believe that interactions between HIV-1 Gag-Pol molecules trigger the activation of embedded PR (which mediates Gag and Gag-Pol cleavage), and that Gag-Pol assembly domains outside of PR may ...
Yen-Yu Pan, Shiu-Mei Wang, Kuo-Jung Huang, Chien-Cheng Chiang, Chin-Tien Wang   +4 more
doaj   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Conflits agriculteurs-éleveurs et dynamique des ressources de la Tandjile-centre au Tchad [PDF]

Akofena
Résumé : L’article explore la relation complexe entre les activités agricoles et pastorales dans cette région du Tchad, où les ressources naturelles limitées sont au cœur des tensions sociales et économiques L’approche méthodologique adoptée est axée sur
Gag Arnaud ELKOUSSENG & Man-Na DJANGRANG
doaj   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Fabrication of Aligned Polycaprolactone Nanofibrillar Bundles to Control Cell‐Mediated Collagen Deposition in Engineered Cartilage

Advanced Materials, EarlyView.
Melt electrofibrillation (MEF) enables the fabrication of nanofibrillar PCL scaffolds with defined architectures that guide cellular alignment and retention during cartilage tissue engineering. Unlike conventional melt electrowriting, MEF consistently directs collagen type II‐rich extracellular matrix organization, providing a tunable platform to ...
Alba Pueyo Moliner, Lennard Spauwen, James L. Martin Robinson, Ángela García Grech, Isabelle Martinier, Sara Grasselli, Aylin Kara Özenler, Matthias Ryma, Jürgen Groll, Mylène de Ruijter, Jos Malda   +10 more
wiley   +1 more source

Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection [PDF]

, 2008
During acute human immunodeficiency virus type 1 (HIV-1) infection, early host cellular immune responses drive viral evolution. The rates and extent of these mutations, however, remain incompletely characterized.
Carrington, M., Brumme, Z. L., John, M., Altfeld, M., Streeck, H., Markowitz, M., Block, B. L., Kaldor, J., Heckerman, D., Kelleher, A. D., Carlson, J., Jessen, H., Kadie, C., Yuki, Y., Rosenberg, E., Walker, B. D., Eichbaum, Q., Baker, B., Allen, T. M., Brumme, C. J., Mallal, S.   +20 more
core  

Outcomes of primary membranous nephropathy based on serum anti-phospholipase A2 receptor antibodies and glomerular phospholipase A2 receptor antigen status: a retrospective cohort study

Renal Failure, 2020
Introduction Primary membranous nephropathy (PMN) is associated with the anti-phospholipase A2 receptor (anti-PLA2R) antibody in 70% of cases. Some anti-PLA2R-negative patients have the PLA2R antigen in renal tissue.
Peihong Yin, Junxian Wang, Wenyi Liang, Linda Zhan, Yuanhao Liu, Jian Lin, Xiaohong Chen, Yingqin He, Hongyun Jian, Zhibin Xie, Xiaofan Tan, Qing Ye, Fengxian Huang   +12 more
doaj   +1 more source