Results 1 to 10 of about 133,297 (213)

Oligomerization of daptomycin on membranes

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011
Daptomycin is a lipopeptide antibiotic that kills Gram-positive bacteria by membrane depolarization. While it has long been assumed that the mode of action of daptomycin involves the formation of membrane-associated oligomers, this has so far not been ...
Jawad K. Muraih, Jared Silverman, Muraih, Jawad K., Silverman, Jared, Andre Pearson, Palmer, Michael, Pearson, Andre, Michael Palmer   +7 more
core   +3 more sources

Facilitated oligomerization of mycobacterial GroEL: evidence for phosphorylation-mediated oligomerization [PDF]

Journal of Bacteriology, 2009
The distinctive feature of the GroES-GroEL chaperonin system in mediating protein folding lies in its ability to exist in a tetradecameric state, form a central cavity, and encapsulate the substrate via the GroES lid.
Tyagi, Anil K., Mande, Shekhar C., Kumar, Santosh C. M., Khare, Garima, Srikanth, C. V., Sardesai, Abhijit A.   +5 more
core   +4 more sources

Structural Interplays in the Flexible N-Terminus and Scaffolding Domain of Human Membrane Protein Caveolin 3

Membranes, 2021
Caveolins are critical for the formation of caveolae, which are small invaginations of the plasma membrane involved in a variety of biological processes.
Hae-Jun Park, Jinhwa Jang, Kyung-Suk Ryu, Jinhyuk Lee, Sung-Hee Lee, Hyung-Sik Won, Eun-Hee Kim, Min-Duk Seo, Ji-Hun Kim   +8 more
doaj   +1 more source

Protein Oligomerization

International Journal of Molecular Sciences, 2023
Protein self-association is a biologically remarkable event that involves and affects the structural and functional properties of proteins [...]
Gotte, Giovanni, Menegazzi, Marta
openaire   +3 more sources

Effects of Serine or Threonine in the Active Site of Typical 2-Cys Prx on Hyperoxidation Susceptibility and on Chaperone Activity

Antioxidants, 2021
Typical 2-Cys peroxiredoxins (2-Cys Prx) are ubiquitous Cys-based peroxidases, which are stable as decamers in the reduced state, and may dissociate into dimers upon disulfide bond formation.
Carlos A. Tairum, Melina Cardoso Santos, Carlos Alexandre Breyer, Ana Laura Pires de Oliveira, Vitoria Isabela Montanhero Cabrera, Guilherme Toledo-Silva, Gustavo Maruyama Mori, Marcos Hikari Toyama, Luis Eduardo Soares Netto, Marcos Antonio de Oliveira   +9 more
doaj   +1 more source

Oligomer formation of SARS-CoV-2 ORF8 through 73YIDI76 motifs regulates immune response and non-infusion antiviral interactions

Frontiers in Molecular Biosciences, 2023
Introduction: Open Reading Frame 8 (ORF8) is a 121 amino acid length SARS-CoV-2 specific accessory protein that plays crucial roles in viral infectivity, and pathogenesis.
Mohammad Assadizadeh, Maryam Azimzadeh Irani   +1 more
doaj   +1 more source

Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein

Frontiers in Neuroscience, 2021
α-synuclein (αSyn) is the main protein component of Lewy bodies, intracellular inclusions found in the brain of Parkinson’s disease (PD) patients. Neurotoxic αSyn species are broadly modified post-translationally and, in patients with genetic forms of PD,
Ana Martinez Hernandez, Ivan Silbern, Ivan Silbern, Insa Geffers, Lars Tatenhorst, Lars Tatenhorst, Lars Tatenhorst, Stefan Becker, Henning Urlaub, Henning Urlaub, Markus Zweckstetter, Markus Zweckstetter, Markus Zweckstetter, Christian Griesinger, Christian Griesinger, Christian Griesinger, Gregor Eichele   +16 more
doaj   +1 more source

Minimal Yet Powerful: The Role of Archaeal Small Heat Shock Proteins in Maintaining Protein Homeostasis

Frontiers in Molecular Biosciences, 2022
Small heat shock proteins (sHsp) are a ubiquitous group of ATP-independent chaperones found in all three domains of life. Although sHsps in bacteria and eukaryotes have been studied extensively, little information was available on their archaeal homologs
Mousam Roy, Koustav Bhakta, Abhrajyoti Ghosh   +2 more
doaj   +1 more source

Synthesis of a Ni Complex Chelated by a [2.2]Paracyclophane-Functionalized Diimine Ligand and Its Catalytic Activity for Olefin Oligomerization

Molecules, 2021
A diimine ligand having two [2.2]paracyclophanyl substituents at the N atoms (L1) was prepared from the reaction of amino[2.2]paracyclophane with acenaphtenequinone.
Daisuke Takeuchi, Yoshi-aki Tojo, Kohtaro Osakada   +2 more
doaj   +1 more source

Concentration‐dependent oligomerization and oligomeric arrangement of LptA [PDF]

Protein Science, 2011
AbstractGram‐negative bacteria such as Escherichia coli have an inner membrane and an asymmetric outer membrane (OM) that together protect the cytoplasm and act as a highly selective permeability barrier. Lipopolysaccharide (LPS) is the major component of the outer leaflet of the OM and is essential for the survival of nearly all Gram‐negative bacteria.
Jacqueline A, Merten, Kathryn M, Schultz, Candice S, Klug   +2 more
openaire   +2 more sources