Results 41 to 50 of about 202,274 (300)

Crystallization of Adenylylsulfate Reductase from Desulfovibrio gigas: A Strategy Based on Controlled Protein Oligomerization [PDF]

, 2011
Adenylylsulfate reductase (adenosine 5′-phosphosulfate reductase, APS reductase or APSR, E.C.1.8.99.2) catalyzes the conversion of APS to sulfite in dissimilatory sulfate reduction. APSR was isolated and purified directly from massive anaerobically grown
Chan, Sunney I., Chen, Chun-Jung, Chiang, Yuan-Lan, Chuankhayan, Phimonphan, Fang, Jou-Yin, Hsieh, Yin-Cheng, Huang, Yen-Chieh, Liu, Ming-Yih, Wang, Vincent C.-C., Yang, Ming-Chi   +9 more
core   +1 more source

Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation

Frontiers in Neuroscience, 2018
Adenosine is a nucleoside mainly formed by degradation of ATP, located intracellularly or extracellularly, and acts as a neuromodulator. It operates as a volume transmission signal through diffusion and flow in the extracellular space to modulate the ...
Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Sonja Hinz, Gemma Navarro, Rafael Franco, Christa E. Müller, Kjell Fuxe   +7 more
doaj   +1 more source

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress [PDF]

, 2020
IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress.
Acosta-Alvear, Adrienne W. Paton, Amin-Wetzel, Bertolotti, Bertolotti, Calfon, Chang, Delphine De Sutter, Eva Cloots, Feldman, Haber, Heidi De Luca, Hetz, Hollien, Hollien, Imagawa, Iwawaki, Iwawaki, James C. Paton, Jay R. Thiagarajah, Karagöz, Lee, Li, Lisbona, Lu, Mariska S. Simpson, Markus A. Seeliger, Martino, Mi, Michael J. Grey, Miyoshi, Nicole LeDuc, Paton, Paton, Phi Luong, Prischi, Sepulveda, Shemorry, Singh, Sophie Janssens, Sundaram, Sven Eyckerman, Tam, Tirasophon, Tirasophon, Tschurtschenthaler, Tsuru, Tsuru, Walter, Wang, Wang, Wayne I. Lencer, Wiseman, Yevgeniy V. Serebrenik, Yoshida   +54 more
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Multiscale modeling of interaction of alane clusters on Al(111) surfaces: A reactive force field and infrared absorption spectroscopy approach [PDF]

, 2010
We have used reactive force field (ReaxFF) to investigate the mechanism of interaction of alanes on Al(111) surface. Our simulations show that, on the Al(111) surface, alanes oligomerize into larger alanes.
Chabal, Yves J., Chaudhuri, Santanu, Goddard, William A., III, Kramer, Gert Jan, Ojwang, J. G. O., van Duin, Adri C. T., van Santen, Rutger, Veyan, Jean-Francois   +7 more
core   +1 more source

Temporal dependence of neuronal alpha-synuclein oligomerization and nuclear translocation induced by paraquat

环境与职业医学, 2022
BackgroundParaquat (PQ), one of the environmental poisons associated with sporadic Parkinson's disease (PD), can cause abnormal aggregation of alpha-synuclein (α-syn), but the research on its conformational changes and subcellular localization is limited.
Baofu ZHANG, Kaidong WANG, Bingyang ZHANG, Min HUANG   +3 more
doaj   +1 more source

GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET [PDF]

, 2009
The mouse γ-aminobutyric acid (GABA) transporter mGAT1 was expressed in neuroblastoma 2a cells. 19 mGAT1 designs incorporating fluorescent proteins were functionally characterized by [^3H]GABA uptake in assays that responded to several experimental ...
Abramoff, Bal, Bal, Bartholomäus, Bauman, Bjerggaard, Blackman, Boudanova, Boyd, Brückner, Chen, Chiu, Chiu, Cole, Corry, Corry, Deken, Doherty, Drenan, Elangovan, Farhan, Farhan, Farhan, Farhan, Feige, Fraser J. Moss, Gauthier, Geiser, Gordon, Guastella, Harris, Hastrup, Henry A. Lester, Hess, Holton, Hu, Hung, Imoukhuede, Jares-Erijman, Jia Hu, Joanna L. Jankowsky, Just, Kanner, Kanner, Kerschensteiner, Khakh, Kilic, Kimberly Scott, Korkhov, Kuryatov, Lakowicz, Lakowicz, Lester, Lester, Li, Lin, Loder, Loo, Madsen, Mager, Manley, Mazei-Robison, McHugh, Melikian, Michael W. Quick, Miranda, Miranda, Morel, Munro, Nashmi, Nashmi, Ormö, P.I. Imoukhuede, Quick, Raicu, Raicu, Ramamoorthy, Reiterer, Reith, Riven, Rizzo, Roux, Rudnick, Rudnick, Sallette, Schmid, Scholze, Sekar, Sheng, Son, Soragna, Sorkina, Spudich, Tadross, Taunton, Tokunaga, Torres, Torres, Wallrabe, Wang, Whitworth, Xia, Yamashita, Zacharias, Zahniser, Zhang   +105 more
core   +3 more sources

Oligomerization Route to Py-Im Polyamide Macrocycles [PDF]

, 2009
Cyclic eight-ring pyrrole−imidazole polyamides are sequence-specific DNA-binding small molecules that are cell permeable and can regulate endogenous gene expression.
Chenoweth, David M., Dervan, Peter B., Harki, Daniel A.   +2 more
core   +2 more sources

Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight

Viruses, 2018
The mitochondrial antiviral signaling (MAVS) adaptor protein is a central signaling hub required for cells to mount an antiviral response following virus sensing by retinoic acid-inducible gene I (RIG-I)-like receptors.
Natalia Zamorano Cuervo, Quentin Osseman, Nathalie Grandvaux   +2 more
doaj   +1 more source

VDAC1 oligomerization may enhance DDP‐induced hepatocyte apoptosis by exacerbating oxidative stress and mitochondrial DNA damage

FEBS Open Bio, 2022
Cisplatin (DDP)‐based chemotherapy is a preferred treatment for a broad spectrum of cancers, but the precise mechanisms of its hepatotoxicity are not yet clear.
Xueqin Zhu, Lei Luo, Yanyan Xiong, Nan Jiang, Yurun Wang, Yuan Lv, Ying Xie   +6 more
doaj   +1 more source

Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]

, 2012
Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi, A. J. de Jesus, A. Reddy, Barochia, Bevan, Bokhari, Dziarski, H. Yin, Hargreaves, Hoshino, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, J. Thomas, Jacquet, Joce, K. Cheng, K. Ramos, Kirikae, L. C. Loram, L. R. Watkins, Lewis, Li, Liu, Liu, M. R. Hutchinson, Manavalan, Milligan, Nagyoszi, Narita, Ohto, Park, Resman, Rice, Slivka, Takeuchi, Viriyakosol, Watkins, X. Wang, Youn   +42 more
core   +2 more sources