Results 41 to 50 of about 133,297 (213)

Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation

Frontiers in Neuroscience, 2018
Adenosine is a nucleoside mainly formed by degradation of ATP, located intracellularly or extracellularly, and acts as a neuromodulator. It operates as a volume transmission signal through diffusion and flow in the extracellular space to modulate the ...
Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Sonja Hinz, Gemma Navarro, Rafael Franco, Christa E. Müller, Kjell Fuxe   +7 more
doaj   +1 more source

Muscarinic receptor oligomerization [PDF]

Neuropharmacology, 2018
G protein-coupled receptors (GPCRs) have been classically described as monomeric entities that function by binding in a 1:1 stoichiometric ratio to both ligand and downstream signalling proteins. However, in recent years, a growing number of studies has supported the hypothesis that these receptors can interact to form dimers and higher order oligomers
Marsango, Sara, Ward, Richard J., Alvarez-Curto, Elisa, Milligan, Graeme   +3 more
openaire   +2 more sources

The Oligomerization Landscape of Histones [PDF]

Biophysical Journal, 2018
ABSTRACT In eukaryotes, DNA is packaged within nucleosomes. The DNA of each nucleosome is typically centered around an octameric histone protein core: one central tetramer plus two separate dimers. Studying the assembly mechanisms of histones is essential for understanding the dynamics of entire nucleosomes and higher-
Zhao, Haiqing, Winogradoff, David, Dalal, Yamini, Papoian, Garegin A.   +3 more
openaire   +2 more sources

Temporal dependence of neuronal alpha-synuclein oligomerization and nuclear translocation induced by paraquat

环境与职业医学, 2022
BackgroundParaquat (PQ), one of the environmental poisons associated with sporadic Parkinson's disease (PD), can cause abnormal aggregation of alpha-synuclein (α-syn), but the research on its conformational changes and subcellular localization is limited.
Baofu ZHANG, Kaidong WANG, Bingyang ZHANG, Min HUANG   +3 more
doaj   +1 more source

Targeting the oligomerization of BCR/ABL by membrane permeable competitive peptides inhibits the proliferation of Philadelphia Chromosome positive leukemic cells

, 2013
The BCR/ABL fusion protein is the hallmark of Philadelphia Chromosome positive (Ph+) leukemia. The constitutive activation of the ABL-kinase in BCR/ABL cells induces the leukemic phenotype.
Mahajna, Jamal, Schüll, Marion, Najajreh, Yousef, Ruthardt, Martin, Oancea, Claudia, Goldblum, Amiram, Beißert, Tim, Ottmann, Oliver G., Mian, Afsar Ali   +8 more
core   +1 more source

Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight

Viruses, 2018
The mitochondrial antiviral signaling (MAVS) adaptor protein is a central signaling hub required for cells to mount an antiviral response following virus sensing by retinoic acid-inducible gene I (RIG-I)-like receptors.
Natalia Zamorano Cuervo, Quentin Osseman, Nathalie Grandvaux   +2 more
doaj   +1 more source

VDAC1 oligomerization may enhance DDP‐induced hepatocyte apoptosis by exacerbating oxidative stress and mitochondrial DNA damage

FEBS Open Bio, 2022
Cisplatin (DDP)‐based chemotherapy is a preferred treatment for a broad spectrum of cancers, but the precise mechanisms of its hepatotoxicity are not yet clear.
Xueqin Zhu, Lei Luo, Yanyan Xiong, Nan Jiang, Yurun Wang, Yuan Lv, Ying Xie   +6 more
doaj   +1 more source

Fluorescence fluctuation analysis of Arabidopsis thaliana somatic embryogenesis receptor-like kinase and brassinosteroid insensitive 1 receptor ologomerization.

, 2008
Receptor kinases play a key role in the cellular perception of signals. To verify models for receptor activation through dimerization, an experimental system is required to determine the precise oligomerization status of proteins within living cells ...
Vries, S.C., de, Russinova, Eugenia, Visser, Antonie J.W.G., Shah, K., Vries, S.C., de Vries, Sacco C, Hink, M.A., de Vries, S.C., Shah, Khalid, Hink, Mark A, Visser, A.J.W.G., Russinova, E.T., Visser, Antonie JWG, Hink, Mark A., de Vries, Sacco C., Russinova, E.   +15 more
core   +1 more source

What’s the Defect? Using Mass Defects to Study Oligomerization of Membrane Proteins and Peptides in Nanodiscs with Native Mass Spectrometry

, 2023
Many membrane proteins form functional complexes that are either homo- or hetero-oligomeric. However, it is challenging to characterize membrane protein oligomerization in intact lipid bilayers, especially for polydisperse mixtures.
Michael, Marty, Julia, Townsend
core   +1 more source

Transporter oligomerization: form and function [PDF]

Biochemical Society Transactions, 2016
Transporters are integral membrane proteins with central roles in the efficient movement of molecules across biological membranes. Many transporters exist as oligomers in the membrane. Depending on the individual transport protein, oligomerization can have roles in membrane trafficking, function, regulation and turnover. For example, our recent studies
Alguel, Y, Cameron, AD, Diallinas, G, Byrne, B   +3 more
openaire   +4 more sources