Results 21 to 30 of about 133,297 (213)

Can Short Peptides Be Inhibitors of Serum Amyloid a Protein Aggregation?

Proceedings, 2019
One of the approaches in the design of anti-amyloid drugs is to find compounds that are able to hamper self-association of amyloidogenic protein molecules. [...]
Sandra Skibiszewska, Elzbieta Jankowska
doaj   +1 more source

Overview of the structure and function of the dopamine transporter and its protein interactions

Frontiers in Physiology, 2023
The dopamine transporter (DAT) plays an integral role in dopamine neurotransmission through the clearance of dopamine from the extracellular space. Dysregulation of DAT is central to the pathophysiology of numerous neuropsychiatric disorders and as such ...
Binod Nepal, Sanjay Das, Maarten E. Reith, Sandhya Kortagere   +3 more
doaj   +1 more source

Heterologous Expression of Immature Forms of Human Islet Amyloid Polypeptide in Yeast Triggers Intracellular Aggregation and Cytotoxicity

Frontiers in Microbiology, 2020
Diabetes is a major public health issue that has attained alarming levels worldwide. Pancreatic aggregates of human islet amyloid polypeptide (IAPP) represent a major histopathological hallmark of type 2 diabetes.
Ana F. Raimundo, Ana F. Raimundo, Ana F. Raimundo, Sofia Ferreira, Sofia Ferreira, Maria I. Farrim, Cláudia N. Santos, Cláudia N. Santos, Cláudia N. Santos, Regina Menezes, Regina Menezes, Regina Menezes   +11 more
doaj   +1 more source

GPCRs Revisited: New Insights Lead to Novel Drugs

Pharmaceuticals, 2011
GPCRs play a critical role in human physiology and are a prime target for drug discovery globally. Novel insights into the functions of GPCRs are providing unique approaches to modulate these proteins to generate unique drug candidates.
Terry Reisine, Richard M. Eglen
doaj   +1 more source

Rethinking Leucine Zipper : ribonuclease activity and structural dynamics of a ubiquitous oligomerization motif [PDF]

, 2011
This dissertation focuses on structural, dynamic and catalytic properties of a Leucine Zipper (LZ) motif – a family of protein oligomerization domains which belong to the structural class of coiled coil proteins.
Nikolaev, Yaroslav
core   +1 more source

Distinct Pathway of Human T-Cell Leukemia Virus Type 1 Gag Punctum Biogenesis Provides New Insights into Enveloped Virus Assembly

mBio, 2018
The assembly of virus particles is a crucial aspect of virus spread. For retroviruses, the Gag polyprotein is the key driver for virus particle assembly.
John P. Eichorst, Yan Chen, Joachim D. Mueller, Louis M. Mansky   +3 more
doaj   +1 more source

Activation and Oligomerization of Aspartylglucosaminidase [PDF]

Journal of Biological Chemistry, 1998
Secretory, membrane, and lysosomal proteins undergo covalent modifications and acquire their secondary and tertiary structure in the lumen of the endoplasmic reticulum (ER). In order to pass the ER quality control system and become transported to their final destinations, many of them are also assembled into oligomers.
J, Saarela, M, Laine, R, Tikkanen, C, Oinonen, A, Jalanko, J, Rouvinen, L, Peltonen   +6 more
openaire   +2 more sources

Inhibition of Aβ42 oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs [PDF]

, 2016
The formation of small Aβ42 oligomers has been implicated as a toxic species in Alzheimer disease (AD). In strong support of this hypothesis we found that overexpression of Yap1802, the yeast ortholog of the human AD risk factor, phosphatidylinositol ...
Maria Valencik, Ratia, Kiira, Liebman, Ba, Mariam A., Sei-Kyoung Park, Susan W. Liebman, Kiira Ratia, Mariam Ba, Park, Sei-Kyoung, Liebman, Susan W., Valencik, Maria L.   +10 more
core   +1 more source

Interactions and substrate selectivity within the SctRST complex of the type III secretion system of enteropathogenic Escherichia coli

Gut Microbes, 2022
Many bacterial pathogens employ a protein complex, termed the type III secretion system (T3SS), to inject bacterial effectors into host cells. These effectors manipulate various cellular processes to promote bacterial growth and survival.
Irit Tseytin, Shir Lezerovich, Nofar David, Neta Sal-Man   +3 more
doaj   +1 more source

ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]

, 2016
A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Hiller, Sebastian, Broz, Petr, Dick, Mathias S., Rühl, Sebastian, Sborgi, Lorenzo   +4 more
core   +1 more source