Results 31 to 40 of about 141,462 (202)

Recombinant Zea mays profilin forms multimers with pan-allergenic potential

Allergology International, 2000
European studies have shown that approximately 20% of all pollen-allergic patients display IgE reactivity to various plant profilins. Profilins are ubiquitous intracellular proteins, with a role in cell signalling and morphology.
Telly Psaradellis, Neil L Kao, Michael Babich   +2 more
doaj   +1 more source

The Roles of Intracellular Chaperone Proteins, Sigma Receptors, in Parkinson’s Disease (PD) and Major Depressive Disorder (MDD)

Frontiers in Pharmacology, 2019
Sigma receptors, including Sigma-1 receptors and Sigma-2 receptors, are highly expressed in the CNS. They are intracellular chaperone proteins. Sigma-1 receptors localize mainly at the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM ...
Kai Yang, Changcai Wang, Taolei Sun, Taolei Sun   +3 more
doaj   +1 more source

The Structure of the Oligomerization Domain of Lsr2 from Mycobacterium tuberculosis Reveals a Mechanism for Chromosome Organization and Protection [PDF]

, 2012
Lsr2 is a small DNA-binding protein present in mycobacteria and related actinobacteria that regulates gene expression and influences the organization of bacterial chromatin.
Isabel Usón (319527), Kathrin Meindl, Isabel Usón, Usón Isabel, Arcus Vickery L., David Alland, Radjainia Mazdak, David Alland (31640), Alland, David, Radjainia, Mazdak, Summers, Emma Louise, Vickery L. Arcus (319529), Roberto Colangeli, Alland David, Mazdak Radjainia, Mitra Alok K., Kathrin Meindl (319526), Emma L. Summers (319525), Alok K. Mitra (206395), Roberto Colangeli (31628), Colangeli Roberto, Colangeli, Roberto, Emma L Summers, Meindl, Kathrin, Vickery L Arcus, Summers Emma L., Mazdak Radjainia (319528), Alok K Mitra, Summers, Emma L., Mitra, Alok K., Meindl Kathrin, Arcus, Vickery L., Usón, Isabel   +32 more
core   +2 more sources

Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex

eLife, 2017
The GIPC family adaptor proteins mediate endocytosis by tethering cargo proteins to the myosin VI motor. The structural mechanisms for the GIPC/cargo and GIPC/myosin VI interactions remained unclear.
Guijun Shang, Chad A Brautigam, Rui Chen, Defen Lu, Jesús Torres-Vázquez, Xuewu Zhang   +5 more
doaj   +1 more source

Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit

eLife, 2018
Ribonucleotide reductases (RNRs) are key enzymes in DNA metabolism, with allosteric mechanisms controlling substrate specificity and overall activity. In RNRs, the activity master-switch, the ATP-cone, has been found exclusively in the catalytic subunit.
Inna Rozman Grinberg, Daniel Lundin, Mahmudul Hasan, Mikael Crona, Venkateswara Rao Jonna, Christoph Loderer, Margareta Sahlin, Natalia Markova, Ilya Borovok, Gustav Berggren, Anders Hofer, Derek T Logan, Britt-Marie Sjöberg   +12 more
doaj   +1 more source

Tailoring solid catalysts for the ethene oligomerization reaction

, 2021
The selective oligomerization of ethene to linear alpha olefins is an attractive method for production of a wide range of key intermediates for the chemical industry.
Kømurcu, Mustafa Sæterdal
core   +1 more source

Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components

eLife, 2017
FGF2 is secreted from cells by an unconventional secretory pathway. This process is mediated by direct translocation across the plasma membrane.
Julia P Steringer, Sascha Lange, Sabína Čujová, Radek Šachl, Chetan Poojari, Fabio Lolicato, Oliver Beutel, Hans-Michael Müller, Sebastian Unger, Ünal Coskun, Alf Honigmann, Ilpo Vattulainen, Martin Hof, Christian Freund, Walter Nickel   +14 more
doaj   +1 more source

Combined treatment with Sigma1R and A2AR agonists fails to inhibit cocaine self-administration despite causing strong antagonistic accumbal A2AR-D2R complex interactions: the potential role of astrocytes

Frontiers in Molecular Neuroscience, 2023
Previous studies have indicated that acute treatment with the monoamine stabilizer OSU-6162 (5 mg/kg), which has a high affinity for Sigma1R, significantly increased the density of accumbal shell D2R-Sigma1R and A2AR-D2R heteroreceptor complexes ...
Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Alexander Lopez-Salas, Karolina Wydra, Marco Bartolini, Marco Bartolini, Zilong Zhou, Zilong Zhou, Malgorzata Frankowska, Agata Suder, Javier Benitez-Porres, Wilber Romero-Fernandez, Wilber Romero-Fernandez, Malgorzata Filip, Kjell Fuxe   +15 more
doaj   +1 more source

SLC6 transporter oligomerization [PDF]

Journal of Neurochemistry, 2020
AbstractTransporters of the solute carrier 6 (SLC6) family mediate the reuptake of neurotransmitters such as dopamine, norepinephrine, serotonin, GABA, and glycine. SLC6 family members are 12 transmembrane helix‐spanning proteins that operate using the transmembrane sodium gradient for transport.
Kumaresan Jayaraman, Anand K. Das, Dino Luethi, Dániel Szöllősi, Gerhard J. Schütz, Maarten E. A. Reith, Harald H. Sitte, Thomas Stockner   +7 more
openaire   +2 more sources

Membrane Heteroreceptor Complexes as Second-Order Protein Modulators: A Novel Integrative Mechanism through Allosteric Receptor–Receptor Interactions

Membranes
Bioluminescence and fluorescence resonance energy transfer (BRET and FRET) together with the proximity ligation method revealed the existence of G-protein-coupled receptors, Ionotropic and Receptor tyrosine kinase heterocomplexes, e.g., A2AR–D2R, GABAA ...
Marina Mirchandani-Duque, Malak Choucri, Juan C. Hernández-Mondragón, Minerva Crespo-Ramírez, Catalina Pérez-Olives, Luca Ferraro, Rafael Franco, Miguel Pérez de la Mora, Kjell Fuxe, Dasiel O. Borroto-Escuela   +9 more
doaj   +1 more source