Results 11 to 20 of about 202,274 (300)
Muscarinic receptor oligomerization [PDF]
Neuropharmacology, 2018 G protein-coupled receptors (GPCRs) have been classically described as monomeric entities that function by binding in a 1:1 stoichiometric ratio to both ligand and downstream signalling proteins. However, in recent years, a growing number of studies has supported the hypothesis that these receptors can interact to form dimers and higher order oligomers
Marsango, Sara +3 more
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International Journal of Molecular Sciences, 2023 Protein self-association is a biologically remarkable event that involves and affects the structural and functional properties of proteins [...]
Gotte, Giovanni, Menegazzi, Marta
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SLC6 transporter oligomerization [PDF]
Journal of Neurochemistry, 2020 AbstractTransporters of the solute carrier 6 (SLC6) family mediate the reuptake of neurotransmitters such as dopamine, norepinephrine, serotonin, GABA, and glycine. SLC6 family members are 12 transmembrane helix‐spanning proteins that operate using the transmembrane sodium gradient for transport.
Kumaresan Jayaraman +7 more
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A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. [PDF]
, 2013 Activation of the IκB kinase (IKK) is central to NF-κB signaling. However, the precise activation mechanism by which catalytic IKK subunits gain the ability to induce NF-κB transcriptional activity is not well understood.
Fusco, Amanda J +11 more
core +6 more sources
Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides [PDF]
, 2012 In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Beez, Sabine +2 more
core +9 more sources
Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation. [PDF]
, 2020 Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor ...
Bisom-Rapp, Ezra W +4 more
core +2 more sources
GPCR homo-oligomerization [PDF]
Current Opinion in Cell Biology, 2019 G protein-coupled receptors (GPCRs) are an extensive class of trans-plasma membrane proteins that function to regulate a wide range of physiological functions. Despite a general perception that GPCRs exist as monomers an extensive literature has examined whether GPCRs can also form dimers and even higher-order oligomers, and if such organization ...
Milligan, Graeme +2 more
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Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation
Frontiers in Molecular Neuroscience, 2021 Aggregation of α-synuclein (αSyn) into proteinaceous deposits is a pathological hallmark of a range of neurodegenerative diseases including Parkinson’s disease (PD).
Blagovesta Popova +12 more
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An unfolded protein-induced conformational switch activates mammalian IRE1. [PDF]
, 2017 The unfolded protein response (UPR) adjusts the cell's protein folding capacity in the endoplasmic reticulum (ER) according to need. IRE1 is the most conserved UPR sensor in eukaryotic cells.
Acosta-Alvear, Diego +5 more
core +3 more sources
Can Short Peptides Be Inhibitors of Serum Amyloid a Protein Aggregation?
Proceedings, 2019 One of the approaches in the design of anti-amyloid drugs is to find compounds that are able to hamper self-association of amyloidogenic protein molecules. [...]
Sandra Skibiszewska, Elzbieta Jankowska
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