Results 11 to 20 of about 133,297 (213)

Insights into Aldehyde Dehydrogenase Enzymes: A Structural Perspective

Frontiers in Molecular Biosciences, 2021
Aldehyde dehydrogenases engage in many cellular functions, however their dysfunction resulting in accumulation of their substrates can be cytotoxic. ALDHs are responsible for the NAD(P)-dependent oxidation of aldehydes to carboxylic acids, participating ...
Kim Shortall, Ahmed Djeghader, Edmond Magner, Tewfik Soulimane   +3 more
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Exploring the Oligomerization of Nav1.5 and Its Implication for the Dominant-Negative Effect [PDF]

, 2023
Clusters of the α-subunit of voltage-gated sodium (Nav) channels have been observed in various tissues and are recognized as key regulators of cellular excitability and action potential propagation.
Iamshanova, Oksana, Rougier, Jean-Sébastien, Abriel, Hugues   +2 more
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Design of Protegrin-1 Analogs with Improved Antibacterial Selectivity

Pharmaceutics, 2023
Protegrin-1 (PG-1) is a cationic β-hairpin pore-forming antimicrobial peptide having a membranolytic mechanism of action. It possesses in vitro a potent antimicrobial activity against a panel of clinically relevant MDR ESKAPE pathogens.
Ilia A. Bolosov, Pavel V. Panteleev, Sergei V. Sychev, Veronika A. Khokhlova, Victoria N. Safronova, Ilia Yu. Toropygin, Tatiana I. Kombarova, Olga V. Korobova, Eugenia S. Pereskokova, Alexander I. Borzilov, Tatiana V. Ovchinnikova, Sergey V. Balandin   +11 more
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Oligomerization-Enhanced Receptor–Ligand Binding Revealed by Dual-Color Simultaneous Tracking on Living Cell Membranes

, 2021
GPCR oligomerization plays a critical role in cellular signaling, yet the stoichiometry of the interactions between oligomers and binding ligands in living cells remains a longstanding challenge.
Hua He (120374), Xiaoqiang Wang (194829), Xiaoxi Yu (8539872), Xiaojuan Wang (105141), Baosheng Ge (19061), Yanzhi Ding, Hengheng Liu, Hengheng Liu (11302667), Xiaojuan Wang, Fang Huang, Daoyong Yu, Hua He, Fang Huang (154302), Daoyong Yu (249993), Jiqiang Li, Baosheng Ge, Jiqiang Li (1598467), Yanzhi Ding (11302664), Xiaoqiang Wang, Xiaoxi Yu   +19 more
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First Principles Analysis of Ethylene Oligomerization on Single-site Ga3+ Catalysts Supported on Amorphous Silica

, 2021
Amorphous, single site, silica-supported main group metal catalysts have recently been found to promote olefin oligomerization with high activity at moderate temperatures and pressures (~250°C and 1 atm).
Yinan, Xu, Jeffrey, Greeley, Jeffrey, Miller, Nicole, LiBretto, Guanghui, Zhang   +4 more
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Concentration- and pH-Dependent Oligomerization of the Thrombin-Derived C-Terminal Peptide TCP-25

Biomolecules, 2020
Peptide oligomerization dynamics affects peptide structure, activity, and pharmacodynamic properties. The thrombin C-terminal peptide, TCP-25 (GKYGFYTHVFRLKKWIQKVIDQFGE), is currently in preclinical development for improved wound healing and infection ...
Ganna Petruk, Jitka Petrlova, Firdaus Samsudin, Rita Del Giudice, Peter J. Bond, Artur Schmidtchen   +5 more
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Differential FSH Glycosylation Modulates FSHR Oligomerization and Subsequent cAMP Signaling

Frontiers in Endocrinology, 2021
Follicle-stimulating hormone (FSH) and its target G protein-coupled receptor (FSHR) are essential for reproduction. Recent studies have established that the hypo-glycosylated pituitary FSH glycoform (FSH21/18), is more bioactive in vitro and in vivo than
Uchechukwu T. Agwuegbo, Emily Colley, Anthony P. Albert, Viktor Y. Butnev, George R. Bousfield, Kim C. Jonas   +5 more
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SLC6 transporter oligomerization [PDF]

Journal of Neurochemistry, 2020
AbstractTransporters of the solute carrier 6 (SLC6) family mediate the reuptake of neurotransmitters such as dopamine, norepinephrine, serotonin, GABA, and glycine. SLC6 family members are 12 transmembrane helix‐spanning proteins that operate using the transmembrane sodium gradient for transport.
Kumaresan Jayaraman, Anand K. Das, Dino Luethi, Dániel Szöllősi, Gerhard J. Schütz, Maarten E. A. Reith, Harald H. Sitte, Thomas Stockner   +7 more
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Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation

Frontiers in Molecular Neuroscience, 2021
Aggregation of α-synuclein (αSyn) into proteinaceous deposits is a pathological hallmark of a range of neurodegenerative diseases including Parkinson’s disease (PD).
Blagovesta Popova, Dan Wang, Abirami Rajavel, Karthikeyan Dhamotharan, Diana F. Lázaro, Jennifer Gerke, Joachim F. Uhrig, Michael Hoppert, Tiago F. Outeiro, Tiago F. Outeiro, Tiago F. Outeiro, Tiago F. Outeiro, Gerhard H. Braus   +12 more
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GPCR-OKB: the G protein coupled receptor oligomer knowledge base [PDF]

, 2010
Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically.
Bas Vroling, Pin, J.-P., Palczewski, K., Camacho-Artacho, Marta, Pin, J.P., Lucy Skrabanek, Jean-Philippe Pin, Marta Camacho-Artacho, Devi, Lakshmi A, Graeme Milligan, Marta Filizola, Campagne, Fabien, Fabien Campagne, Martin J. Lohse, Jufang Shan, Lohse, Martin J, Vriend, Gerrit, Khelashvili, George, Milligan, Graeme, Camacho-Artacho, M., Skrabanek, L., George Khelashvili, Campagne, F., Susan R. George, Lakshmi A. Devi, Filizola, M., Pin, Jean-Philippe, Vroling, B., Bouvier, M., Devi, L.A., Richard R. Neubig, Marc Parmentier, George, Susan R, Palczewski, Krzysztof, Dorff, K., Shan, J., Vriend, G., Michel Bouvier, Lohse, M.J., Bouvier, Michel, Skrabanek, Lucy, Vroling, Bas, Filizola, Marta, Neubig, Richard R, Gerrit Vriend, Dorff, Kevin, Parmentier, Marc, Khelashvili, G., Javitch, J.A., Shan, Jufang, Parmentier, M., Javitch, Jonathan A, Krzysztof Palczewski, Kevin Dorff, Jonathan A. Javitch, George, S.R., Neubig, R.R., Milligan, G.   +57 more
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