Results 61 to 70 of about 133,297 (213)

Structural basis of IRGB10 oligomerization by GTP hydrolysis

Frontiers in Immunology, 2023
Immunity-related GTPase B10 (IRGB10) is a crucial member of the interferon (IFN)-inducible GTPases and plays a vital role in host defense mechanisms.
Hyun Ji Ha, Ju Hyeong Kim, Ju Hyeong Kim, Gwan Hee Lee, Gwan Hee Lee, Subin Kim, Subin Kim, Hyun Ho Park, Hyun Ho Park   +8 more
doaj   +1 more source

Functional analysis and cryo-electron microscopy of Campylobacter jejuni serine protease HtrA

Gut Microbes, 2020
Campylobacter jejuni is a predominant zoonotic pathogen causing gastroenteritis and other diseases in humans. An important bacterial virulence factor is the secreted serine protease HtrA (HtrACj), which targets tight and adherens junctional proteins in ...
Urszula Zarzecka, Alessandro Grinzato, Eaazhisai Kandiah, Dominik Cysewski, Paola Berto, Joanna Skorko-Glonek, Giuseppe Zanotti, Steffen Backert   +7 more
doaj   +1 more source

Biological Role of Arrestin-1 Oligomerization [PDF]

, 2020
Members of the arrestin superfamily have great propensity of self-association, but the physiological significance of this phenomenon is unclear. To determine the biological role of visual arrestin-1 oligomerization in rod photoreceptors, we expressed ...
Kook, Seunghyi, Gurevich, Eugenia V, Gurevich, Vsevolod V, Seunghyi Kook, Sergey A. Vishnivetskiy, Thibeault, Kimberly C, Vsevolod V. Gurevich, Vishnivetskiy, Sergey A, Srimal Samaranayake, Burns, Marie E, Camilla R. Shores, Shores, Camilla R, Jeannie Chen, Chen, Jeannie, Samaranayake, Srimal, Marie E. Burns, Kimberly C. Thibeault, Eugenia V. Gurevich   +17 more
core   +1 more source

Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker

eLife, 2015
DnaK/Hsp70 chaperones form oligomers of poorly understood structure and functional significance. Site-specific proteolysis and crosslinking were used to probe the architecture of oligomers formed by the endoplasmic reticulum (ER) Hsp70, BiP.
Steffen Preissler, Joseph E Chambers, Ana Crespillo-Casado, Edward Avezov, Elena Miranda, Juan Perez, Linda M Hendershot, Heather P Harding, David Ron   +8 more
doaj   +1 more source

Modern methods to investigate the oligomerization of glycoprotein hormone receptors (TSHR, LHR, FSHR)

, 2013
As for other GPCRs, the oligomerization of glycoprotein hormone receptors (GPHRs) appears as critical event for receptor function. By means of modern techniques based on the BRET or FRET principle, GPHR oligomerization has been reported to explain ...
Luca Persani, M. Bonomi, Marco Bonomi, L. Persani   +3 more
core   +1 more source

Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing [PDF]

, 2007
Airway infection by the Gram-positive pathogen Streptococcus pneumoniae (Sp) leads to recruitment of neutrophils but limited bacterial killing by these cells.
Adam J Ratner, Thomas B Clarke, Elena S Lysenko, Shchepetov Mikhail, Lysenko, Elena S., Clarke, Thomas B., Dowson, Christopher G., Jeffrey N Weiser, Clarke Thomas B, Christopher G Dowson, Dowson Christopher G, Weiser Jeffrey N, Mikhail Shchepetov, Ratner, Adam J., Shchepetov, Mikhail, Lysenko Elena S, Roper, David I., Weiser, Jeffrey N., David I Roper, Ratner Adam J, Roper David I   +20 more
core   +1 more source

Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter

eLife, 2018
Clathrin-independent endocytosis (CIE) mediates internalization of many transmembrane proteins but the mechanisms of cargo recruitment during CIE are poorly understood.
Tatiana Sorkina, Shiqi Ma, Mads Breum Larsen, Simon C Watkins, Alexander Sorkin   +4 more
doaj   +1 more source

Tip-induced C--H activation and oligomerization of thienoanthracenes

, 2014
The tip of a scanning tunneling microscope (STM) can be used to dehydrogenate freely-diffusing tetrathienoanthracene (TTA) molecules on Cu(111), trapping the molecules into metal-coordinated oligomeric structures.
Ma, D., Dinca, L.E., MacLeod, J.M., Perepichka, D.F., Fu, C., Rosei, F., Lipton-Duffin, J.   +6 more
core   +1 more source

Electrostatics drive oligomerization and aggregation of human Interferon alpha-2a

, 2021
Aggregation and oligomer formation are critical parameters in the field of protein therapeutics and can lead to loss of drug function or even immunogenic responses in patients.
Sowmya, Indrakumar, Guenther, Peters, Pernille, Harris, Allan, Noergaard, Mikael, Lund, Werner, Streicher, Christin, Pohl, Marco, Polimeni   +7 more
core   +1 more source

Overoxidation and Oligomerization of Trypanosoma cruzi Cytosolic and Mitochondrial Peroxiredoxins

Pathogens, 2023
Peroxiredoxins (Prxs) have been shown to be important enzymes for trypanosomatids, counteracting oxidative stress and promoting cell infection and intracellular survival.
María Dolores Piñeyro, María Laura Chiribao, Diego G. Arias, Carlos Robello, Adriana Parodi-Talice   +4 more
doaj   +1 more source