Results 71 to 80 of about 141,462 (202)

Structural and Functional Insights into the Delivery Systems of Bacillus and Clostridial Binary Toxins

Toxins
Pathogenic Bacillus and clostridial (i.e., Clostridium and Clostridioides) bacteria express a diverse repertoire of effector proteins to promote disease.
Spiridon E. Sevdalis, Kristen M. Varney, Mary E. Cook, Joseph J. Gillespie, Edwin Pozharski, David J. Weber   +5 more
doaj   +1 more source

Can Short Peptides Be Inhibitors of Serum Amyloid a Protein Aggregation?

Proceedings, 2019
One of the approaches in the design of anti-amyloid drugs is to find compounds that are able to hamper self-association of amyloidogenic protein molecules. [...]
Sandra Skibiszewska, Elzbieta Jankowska
doaj   +1 more source

oligomerization

, 2014
Citation: 'oligomerization' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.O04285 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Mutational and computational characterization of transmembrane domains in the fungal G protein-coupled pheromone receptors STE2 and Mam2 [PDF]

G protein-coupled receptors (GPCRs) comprise the largest family of cell-surface receptors involved in sensing a multitude of ligands and are consequently attractive pharmacological targets.
Nilsson Lock, Gun Antonia Evelina
core  

GPCRs Revisited: New Insights Lead to Novel Drugs

Pharmaceuticals, 2011
GPCRs play a critical role in human physiology and are a prime target for drug discovery globally. Novel insights into the functions of GPCRs are providing unique approaches to modulate these proteins to generate unique drug candidates.
Terry Reisine, Richard M. Eglen
doaj   +1 more source

Distinct Pathway of Human T-Cell Leukemia Virus Type 1 Gag Punctum Biogenesis Provides New Insights into Enveloped Virus Assembly

mBio, 2018
The assembly of virus particles is a crucial aspect of virus spread. For retroviruses, the Gag polyprotein is the key driver for virus particle assembly.
John P. Eichorst, Yan Chen, Joachim D. Mueller, Louis M. Mansky   +3 more
doaj   +1 more source

Trans-oligomerization of duplicated aminoacyl-tRNA synthetases maintains genetic code fidelity under stress [PDF]

, 2015
Aminoacyl-tRNA synthetases (aaRSs) play a key role in deciphering the genetic message by producing charged tRNAs and are equipped with proofreading mechanisms to ensure correct pairing of tRNAs with their cognate amino acid.
Rubio, Miguel A., Robinson, N.J., Napolitano, Mauro, Ochoa de Alda, Jesús A.G., Luque, I., Ochoa de Alda, J.A.G., Santamaría-Gómez, Javier, Patterson, C.J., Napolitano, M., Bru-Martinez, Roque, Rubio, M.A., Santamaría-Gómez, J., Bru-Martínez, R., Robinson, Nigel J., Ochoa de Alda, Jesús A. G., Rubio Gómez, Miguel Ángel, Foster, Andrew W., Bru Martínez, Roque, Luque Romero, Ignacio, Rubio, Miguel Ángel, Santamaría Gómez, Javier, Gómez Ochoa de Alda, Jesús Antonio, Patterson, Carl J., Luque, Ignacio, Foster, A.W.   +24 more
core   +1 more source

Small-Molecule Inhibitors of Amyloid Beta: Insights from Molecular Dynamics—Part B: Natural Compounds

Pharmaceuticals
Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive memory loss and cognitive decline. Its key pathological hallmarks include extracellular amyloid plaques composed of amyloid beta (Aβ) peptides and intracellular ...
Mariyana Atanasova
doaj   +1 more source

Biophysical characterization of GPCR oligomerization

, 2013
The biophysical characterization of the fundamental molecular mechanisms behind G-protein coupled receptors (GPCRs) oligomerization is proposed to be paramount for understanding the pharmacological consequence of receptor self-association.
Mathiasen, Signe
core   +1 more source

Rhodopsin Oligomerization and Aggregation

The Journal of Membrane Biology, 2019
Rhodopsin is the light receptor in photoreceptor cells of the retina and a prototypical G protein-coupled receptor. Two types of quaternary structures can be adopted by rhodopsin. If rhodopsin folds and attains a proper tertiary structure, it can then form oligomers and nanodomains within the photoreceptor cell membrane.
openaire   +3 more sources