Results 1 to 10 of about 30,349 (144)

Induced Fit in Protein Multimerization: The HFBI Case. [PDF]

PLoS Computational Biology, 2016
Hydrophobins, produced by filamentous fungi, are small amphipathic proteins whose biological functions rely on their unique surface-activity properties.
Laura Riccardi, Paolo Mereghetti
doaj   +2 more sources

Self-Multimerization of mRNA LNP-Derived Antigen Improves Antibody Responses [PDF]

Vaccines
Background: mRNA LNP technology is now being widely applied as a highly effective vaccine platform. Antigen multimerization is a well-established approach to enhance the antibody titers and protective efficacy of several protein subunit vaccines. However,
Cody A. Despins, James Round, Lisa Dreolini, Tracy S. Lee, Scott D. Brown, Robert A. Holt   +5 more
doaj   +3 more sources

Looking for Novel Capsid Protein Multimerization Inhibitors of Feline Immunodeficiency Virus [PDF]

Pharmaceuticals, 2018
Feline immunodeficiency virus (FIV) is a member of the retroviridae family of viruses. It causes acquired immunodeficiency syndrome (AIDS) in worldwide domestic and non-domestic cats and is a cause of an important veterinary issue.
Natalia Sierra, Christelle Folio, Xavier Robert, Mathieu Long, Christophe Guillon, Guzmán Álvarez   +5 more
doaj   +2 more sources

Split Reporter Systems in Viral Protein–Protein Interactions and Multimerization: Mechanisms and Applications [PDF]

Cells
Protein–protein interactions (PPIs) are fundamental to viral replication, regulating processes such as assembly, genome packaging, and virion maturation.
Haseeb Ahmad, Faizan Masood, Uzair Iqbal, Mohamed Shaltout, Yunus Yukselten, Richard E. Sutton   +5 more
doaj   +2 more sources

Multimerization interactions between protein-inspired single-chain random heteropolymers. [PDF]

PLoS ONE
Single-chain nanoparticles (SCNPs) are attractive for their ability to interact with or behave akin to native proteins. In this work, we use molecular dynamics simulations to examine how SCNPs which are assembled non-covalently due to the hydrophobic ...
Shayna L Hilburg, Tianyi Jin, Priya Ganesh, Alfredo Alexander-Katz   +3 more
doaj   +2 more sources

The signal peptide of staphylococcal protein A alters the multimeric states of PepV [PDF]

Microbiology Spectrum
Signal peptides (SPs) have traditionally been recognized as molecular address tags that direct protein translocation between subcellular compartments. However, emerging evidence suggests that they serve additional functions beyond their canonical role in
Muhammad S. Azam, Dominique Missiakas
doaj   +2 more sources

Interactions Between Hantavirus Nucleoprotein and Glycoproteins: A Quantitative Fluorescence Microscopy Study [PDF]

Viruses
Orthohantaviruses are tri-segmented negative-sense RNA viruses that can cause severe pathologies in humans. Currently, limited information exists on the molecular interactions driving orthohantavirus assembly in infected cells.
Amit Koikkarah Aji, Titas Mandal, Salvatore Chiantia   +2 more
doaj   +2 more sources

TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy

Cell Reports: Methods, 2022
Summary: Tau protein aggregates are a defining neuropathological feature of “tauopathies,” a group of neurodegenerative disorders that include Alzheimer’s disease.
Simon A. Levy, Gabrielle Zuniga, Elias M. Gonzalez, David Butler, Sally Temple, Bess Frost   +5 more
doaj   +1 more source

Tandem Multimerization Can Enhance the Structural Homogeneity and Antifungal Activity of the Silkworm Protease Inhibitor BmSPI39

Cells, 2023
Previous studies have shown that BmSPI39, a serine protease inhibitor of silkworm, can inhibit virulence-related proteases and the conidial germination of insect pathogenic fungi, thereby enhancing the antifungal capacity of Bombyx mori.
Youshan Li, Yuan Wang, Rui Zhu, Xi Yang, Meng Wei, Zhaofeng Zhang, Changqing Chen, Ping Zhao   +7 more
doaj   +1 more source

Insights into the Structures and Multimeric Status of APOBEC Proteins Involved in Viral Restriction and Other Cellular Functions

Viruses, 2021
Apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) proteins belong to a family of deaminase proteins that can catalyze the deamination of cytosine to uracil on single-stranded DNA or/and RNA.
Xiaojiang S. Chen
doaj   +1 more source