Induced Fit in Protein Multimerization: The HFBI Case. [PDF]
PLoS Computational Biology, 2016 Hydrophobins, produced by filamentous fungi, are small amphipathic proteins whose biological functions rely on their unique surface-activity properties.
Laura Riccardi, Paolo Mereghetti
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Designed protein multimerization and polymerization for functionalization of proteins. [PDF]
Biotechnol Lett, 2022 Multimeric and polymeric proteins are large biomacromolecules consisting of multiple protein molecules as their monomeric units, connected through covalent or non-covalent bonds. Genetic modification and post-translational modifications (PTMs) of proteins offer alternative strategies for designing and creating multimeric and polymeric proteins ...
Permana D, Putra HE, Djaenudin D.
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Stochastic protein multimerization, activity, and fitness. [PDF]
Phys Rev E, 2018 Many proteins assemble into homomultimeric structures, with a number of subunits that can vary substantially among phylogenetic lineages. As protein-protein interactions require productive encounters among subunits, such variation might partially be explained by variation in cellular protein abundance. Protein abundance in turn depends on the intrinsic
Hagner K, Setayeshgar S, Lynch M.
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Self-Multimerization of mRNA LNP-Derived Antigen Improves Antibody Responses [PDF]
VaccinesBackground: mRNA LNP technology is now being widely applied as a highly effective vaccine platform. Antigen multimerization is a well-established approach to enhance the antibody titers and protective efficacy of several protein subunit vaccines. However,
Cody A. Despins +5 more
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Looking for Novel Capsid Protein Multimerization Inhibitors of Feline Immunodeficiency Virus [PDF]
Pharmaceuticals, 2018 Feline immunodeficiency virus (FIV) is a member of the retroviridae family of viruses. It causes acquired immunodeficiency syndrome (AIDS) in worldwide domestic and non-domestic cats and is a cause of an important veterinary issue.
Natalia Sierra +5 more
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Split Reporter Systems in Viral Protein–Protein Interactions and Multimerization: Mechanisms and Applications [PDF]
CellsProtein–protein interactions (PPIs) are fundamental to viral replication, regulating processes such as assembly, genome packaging, and virion maturation.
Haseeb Ahmad +5 more
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Multimerization of a rationally designed nanobody for enhanced avidity toward Aβ42 oligomers. [PDF]
Protein SciAbstract Alzheimer's disease affects tens of millions of people worldwide and is associated with the self‐assembly of the Aβ42 peptide into amyloid aggregates. Among the species formed during this process, soluble oligomeric intermediates are the most closely linked to neurotoxicity and are therefore an attractive target for both therapeutic and ...
Nowinska M +3 more
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Multimerization interactions between protein-inspired single-chain random heteropolymers. [PDF]
PLoS ONESingle-chain nanoparticles (SCNPs) are attractive for their ability to interact with or behave akin to native proteins. In this work, we use molecular dynamics simulations to examine how SCNPs which are assembled non-covalently due to the hydrophobic ...
Shayna L Hilburg +3 more
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Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors. [PDF]
ChemMedChemHuman immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Saccoliti F +10 more
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The signal peptide of staphylococcal protein A alters the multimeric states of PepV [PDF]
Microbiology SpectrumSignal peptides (SPs) have traditionally been recognized as molecular address tags that direct protein translocation between subcellular compartments. However, emerging evidence suggests that they serve additional functions beyond their canonical role in
Muhammad S. Azam, Dominique Missiakas
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