Results 21 to 30 of about 30,399 (190)
Plant coilin: structural characteristics and RNA-binding properties. [PDF]
PLoS ONE, 2013 Cajal bodies (CBs) are dynamic subnuclear compartments involved in the biogenesis of ribonucleoproteins. Coilin is a major structural scaffolding protein necessary for CB formation, composition and activity.
Valentine Makarov +7 more
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eLife, 2021 Sterile alpha and toll/interleukin receptor (TIR) motif–containing protein 1 (SARM1) is a neuronally expressed NAD+ glycohydrolase whose activity is increased in response to stress.
Heather S Loring +6 more
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DNA-Mediated Stack Formation of Nanodiscs
Molecules, 2021 Membrane-scaffolding proteins (MSPs) derived from apolipoprotein A-1 have become a versatile tool in generating nano-sized discoidal membrane mimetics (nanodiscs) for membrane protein research.
Madhumalar Subramanian +4 more
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The Evolution of Multimeric Protein Assemblages [PDF]
Molecular Biology and Evolution, 2011 Although the mechanisms by which complex cellular features evolve constitute one of the great unsolved problems of evolutionary biology, it is clear that the emergence of new protein-protein interactions, often accompanied by the diversification of duplicate genes, is involved.
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PRDM9 forms a trimer by interactions within the zinc finger array
Life Science Alliance, 2019 PRDM9 forms a trimer as a soluble protein and in complex with DNA mediated by the ZnF domain. Five ZnFs are already sufficient for multimerization and only one DNA molecule is complexed in the trimer.
Theresa Schwarz +7 more
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Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev. [PDF]
PLoS ONE, 2013 HIV-1 Rev is the key protein in the nucleocytoplasmic export and expression of the late viral mRNAs. An important aspect for its function is its ability to multimerize on these mRNAs.
Thomas Vercruysse +7 more
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Analysis of the initiating events in HIV-1 particle assembly and genome packaging. [PDF]
PLoS Pathogens, 2010 HIV-1 Gag drives a number of events during the genesis of virions and is the only viral protein required for the assembly of virus-like particles in vitro and in cells.
Sebla B Kutluay, Paul D Bieniasz
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Stabilization of Multimeric Proteins via Intersubunit Cyclization [PDF]
Applied and Environmental Microbiology, 2017 ABSTRACT Proteins with high catalytic efficiency and selectivity under mild conditions have long been appreciated by industrial and medicinal fields. These proteins, which are commonly multimeric, often possess low stability, impeding wider application.
Lu Zhu +10 more
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Microbiology Spectrum, 2023 The capsid protein (CA), an essential component of human immunodeficiency virus type 1 (HIV-1), represents an appealing target for antivirals. Small molecules targeting the CAI-binding cavity in the C-terminal domain of HIV-1 CA (CA CTD) confer potent ...
Da-Wei Zhang +4 more
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Rapid Assembly of a Multimeric Membrane Protein Pore [PDF]
Biophysical Journal, 2011 We have observed the assembly of the staphylococcal pore-forming toxin α-hemolysin using single-molecule fluorescence imaging. Surprisingly, assembly from the monomer to the complete heptamer is extremely rapid, occurring in
Thompson, James~R. +3 more
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