Results 21 to 30 of about 3,377,935 (215)

Homotypic Interaction and Multimerization of Hepatitis C Virus Core Protein [PDF]

, 1996
Hepatitis C virus (HCV) core protein constitutes a viral nucleocapsid and may possess multiple functions. In this study, we demonstrated the homotypic interaction and multimerization of HCV core proteinin vitroandin vivo.By using a yeast two-hybrid ...
JENG, KING-SONG, ZHU, NONGLIAO, MATSUMOTO, MASAYUKI, HWANG, SOON B., LAI, MICHAEL M.C.   +4 more
core   +1 more source

Plant coilin: structural characteristics and RNA-binding properties. [PDF]

PLoS ONE, 2013
Cajal bodies (CBs) are dynamic subnuclear compartments involved in the biogenesis of ribonucleoproteins. Coilin is a major structural scaffolding protein necessary for CB formation, composition and activity.
Valentine Makarov, Daria Rakitina, Anna Protopopova, Igor Yaminsky, Alexander Arutiunian, Andrew J Love, Michael Taliansky, Natalia Kalinina   +7 more
doaj   +1 more source

A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration

eLife, 2021
Sterile alpha and toll/interleukin receptor (TIR) motif–containing protein 1 (SARM1) is a neuronally expressed NAD+ glycohydrolase whose activity is increased in response to stress.
Heather S Loring, Victoria L Czech, Janneke D Icso, Lauren O'Connor, Sangram S Parelkar, Alexandra B Byrne, Paul R Thompson   +6 more
doaj   +1 more source

Adiponutrin: A multimeric plasma protein

Biochemical and Biophysical Research Communications, 2014
The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found.
Tinnerfelt Winberg, Martin, Khalaj Motlagh, Mahshid, Stenkula, Karin, Holm, Cecilia, Jones, Helena   +4 more
openaire   +3 more sources

A transient homotypic interaction model for the influenza A virus NS1 protein effector domain [PDF]

, 2011
Influenza A virus NS1 protein is a multifunctional virulence factor consisting of an RNA binding domain (RBD), a short linker, an effector domain (ED), and a C-terminal 'tail'. Although poorly understood, NS1 multimerization may autoregulate its actions.
Margaret A Taylor, Richard E. Randall, García-Sastre, A., Hale Benjamin G., Kerry, P.S., Lewis Andrew, Taylor Margaret A., Kerry, Philip S., Andrew Lewis, Kerry Philip S., Hass, C., Benjamin G. Hale, Hale, Benjamin G., Rupert J. Russell, Juan Ayllon, Richard E Randall, Randall Richard E., Hale, B.G., Margaret A. Taylor, Ayllon, Juan, Philip S Kerry, Randall, R.E., Adolfo García-Sastre, Ayllón Barasoain, Juan, Lewis, Andrew, Hass Claudia, Ayllon, J., Rupert J Russell, García Sastre, Adolfo, Taylor, M.A., Lewis, A., García-Sastre Adolfo, Taylor, Margaret A., Hass, Claudia, Ayllon Juan, Russell, R.J., Randall, Richard E., Claudia Hass, Russell, Rupert J., Benjamin G Hale, Russell Rupert J., Philip S. Kerry, Garcia-Sastre, Adolfo   +42 more
core   +1 more source

Peptide Multimerization as Leads for Therapeutic Development

, 2021
Multimerization of peptide structures has been a logical evolution in their development as potential therapeutic molecules. The multivalent properties of these assemblies have attracted much attention from researchers in the past and the development of ...
Dean E. Sheard, John D. Wade, Wenyi Li, Neil M. O’Brien-Simpson, Frances Separovic   +4 more
core   +1 more source

The host protein Staufen1 interacts with the Pr55^Gag zinc fingers and regulates HIV-1 assembly via its N-terminus

Retrovirology, 2008
Background The formation of new infectious human immunodeficiency type 1 virus (HIV-1) mainly relies on the homo-multimerization of the viral structural polyprotein Pr55Gag and on the recruitment of host factors.
Mouland Andrew J, Boulay Karine, Chatel-Chaix Laurent, DesGroseillers Luc   +3 more
doaj   +1 more source

Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev. [PDF]

PLoS ONE, 2013
HIV-1 Rev is the key protein in the nucleocytoplasmic export and expression of the late viral mRNAs. An important aspect for its function is its ability to multimerize on these mRNAs.
Thomas Vercruysse, Eline Boons, Tom Venken, Els Vanstreels, Arnout Voet, Jan Steyaert, Marc De Maeyer, Dirk Daelemans   +7 more
doaj   +1 more source

Quantifying Asymmetry of Multimeric Proteins

The Journal of Physical Chemistry A, 2018
A large number of proteins assemble as homooligomers. These homooligomers accomplish their function either symmetrically or asymmetrically. If asymmetry is prevalent in a structure ensemble, the asymmetric motion will occur in any of the subunits. Many computational analysis tools implicitly use ensemble averages to determine protein motions, e.g ...
Julian T. Brennecke, Bert L. de Groot
openaire   +4 more sources

PRDM9 forms a trimer by interactions within the zinc finger array

Life Science Alliance, 2019
PRDM9 forms a trimer as a soluble protein and in complex with DNA mediated by the ZnF domain. Five ZnFs are already sufficient for multimerization and only one DNA molecule is complexed in the trimer.
Theresa Schwarz, Yasmin Striedner, Andreas Horner, Karin Haase, Jasmin Kemptner, Nicole Zeppezauer, Philipp Hermann, Irene Tiemann-Boege   +7 more
doaj   +1 more source