Results 31 to 40 of about 30,399 (190)

The role of Cysteine 227 in subcellular localization, water permeability, and multimerization of aquaporin-11

FEBS Open Bio, 2014
Aquaporin-11 (AQP11) is the latest member of the mammalian water channel protein family to be described. Recent in vivo studies have shown that mutation at Cys227 causes renal failure.
Saki Takahashi, Kanako Muta, Hiroko Sonoda, Ayaka Kato, Ahmed Abdeen, Masahiro Ikeda   +5 more
doaj   +1 more source

Order Statistics Theory of Unfolding of Multimeric Proteins [PDF]

Biophysical Journal, 2010
Dynamic force spectroscopy has become indispensable for the exploration of the mechanical properties of proteins. In force-ramp experiments, performed by utilizing a time-dependent pulling force, the peak forces for unfolding transitions in a multimeric protein (D)(N) are used to map the free energy landscape for unfolding for a protein domain D.
Zhmurov, A., Dima, R.I., Barsegov, V.
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Evolutionary diversification of the multimeric states of proteins [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Rather than operating as single units, most proteins assemble as multimers, usually with all subunits derived from the same gene. In contrast to patterns of gene structure and genome organization, which typically exhibit substantial increases in complexity from unicellular to multicellular organisms, the structural complexity of ...
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Structure-Function Relationship of Inclusion Bodies of a Multimeric Protein [PDF]

Frontiers in Microbiology, 2020
High level expression of recombinant proteins in bacteria often results in their aggregation into inclusion bodies. Formation of inclusion bodies poses a major bottleneck in high-throughput recovery of recombinant protein. These aggregates have amyloid-like nature and can retain biological activity. Here, effect of expression temperature on the quality
Anupam Singh, Vaibhav Upadhyay, Akansha Singh, Amulya K. Panda   +3 more
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Functional multimerization of mucolipin channel proteins

Journal of Cellular Physiology, 2009
AbstractMCOLN1 encodes mucolipin‐1 (TRPML1), a member of the transient receptor potential TRPML subfamily of channel proteins. Mutations in MCOLN1 cause mucolipidosis‐type IV (MLIV), a lysosomal storage disorder characterized by severe neurologic, ophthalmologic, and gastrointestinal abnormalities.
Curcio Morelli, Cyntia, Zhang, Peng, Venugopal, Bhuvarahamurthy, Charles, Florie A., Browning, Marsha F., Cantiello, Horacio Fabio, Slaugenhaupt, Susan A.   +6 more
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ASPPs multimerize protein phosphatase 1

PLOS Genetics
Abstract Protein Phosphatase 1 (PP1) activity is thought to be spatiotemporally defined by hundreds of different regulatory subunits, but their mechanisms of action are largely unknown. The Ankyrin repeat, SH3-domain, and Proline-rich region containing Proteins (ASPPs) bind and localize PP1 to cell-cell junctions ...
Derek T. Wei, Kayleigh N. Morrison, Gwendolyn M. Beacham, Erika Beyrent, Ying Zhang, Laurence Florens, Gunther Hollopeter   +6 more
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Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition

eLife, 2022
Intracellular signaling regulators can be concentrated into membrane-free, higher ordered protein assemblies to initiate protective responses during stress — a process known as phase transition. Here, we show that a phase transition of the Caenorhabditis
Nicholas D Peterson, Janneke D Icso, J Elizabeth Salisbury, Tomás Rodríguez, Paul R Thompson, Read Pukkila-Worley   +5 more
doaj   +1 more source

TRIM5α and TRIMCyp form apparent hexamers and their multimeric state is not affected by exposure to restriction-sensitive viruses or by treatment with pharmacological inhibitors

Retrovirology, 2009
Proteins of the TRIM5 family, such as TRIM5α and the related TRIMCyp, are cytoplasmic factors that can inhibit incoming retroviruses. This type of restriction requires a direct interaction between TRIM5 proteins and capsid proteins that are part of ...
Berthoux Lionel, Bérubé Julie, Nepveu-Traversy Marie-Édith   +2 more
doaj   +1 more source

Cochlin, intraocular pressure regulation and mechanosensing. [PDF]

PLoS ONE, 2012
Fluid shear modulates many biological properties. How shear mechanosensing occurs in the extracellular matrix (ECM) and is transduced into cytoskeletal change remains unknown. Cochlin is an ECM protein of unknown function.
Manik Goel, Adam E Sienkiewicz, Renata Picciani, Jianhua Wang, Richard K Lee, Sanjoy K Bhattacharya   +5 more
doaj   +1 more source

Effects of multimerization on the temporal variability of protein complex abundance [PDF]

BMC Systems Biology, 2013
Abstract We explore whether the process of multimerization can be used as a means to regulate noise in the abundance of functional protein complexes. Additionally, we analyze how this process affects the mean level of these functional units, response time of a gene, and temporal correlation between the numbers of expressed proteins and of the
Antti Häkkinen, Huy Tran, Olli Yli-Harja, Brian P. Ingalls, Andre S. Ribeiro   +4 more
openaire   +2 more sources