Results 31 to 40 of about 3,377,935 (215)

A Broad-Spectrum Antiviral Molecule, Protoporphyrin IX, Acts as a Moderator of HIV-1 Capsid Assembly by Targeting the Capsid Hexamer

Microbiology Spectrum, 2023
The capsid protein (CA), an essential component of human immunodeficiency virus type 1 (HIV-1), represents an appealing target for antivirals. Small molecules targeting the CAI-binding cavity in the C-terminal domain of HIV-1 CA (CA CTD) confer potent ...
Da-Wei Zhang, Liangxu Xie, Xiao-Shuang Xu, Yimin Li, Xiaojun Xu   +4 more
doaj   +1 more source

Analysis of the initiating events in HIV-1 particle assembly and genome packaging. [PDF]

PLoS Pathogens, 2010
HIV-1 Gag drives a number of events during the genesis of virions and is the only viral protein required for the assembly of virus-like particles in vitro and in cells.
Sebla B Kutluay, Paul D Bieniasz
doaj   +1 more source

Evolutionarily conserved herpesviral protein interaction networks. [PDF]

, 2009
Herpesviruses constitute a family of large DNA viruses widely spread in vertebrates and causing a variety of different diseases. They possess dsDNA genomes ranging from 120 to 240 kbp encoding between 70 to 170 open reading frames. We previously reported
Bandyopadhyay, Sourav, Baiker Armin, Brunn, Albrecht von, Dong, Yu-An, Silpa Suthram, Haas, Jürgen, Dietlind Rose, von Brunn, Albrecht, Rutenberg Christiane, Ralf Zimmer, Bailer Susanne M., Schmidt, Tina, Stellberger Thorsten, Rose, Dietlind, Haas Jürgen, Titz Björn, Zimmer, Ralf, Christine Zeretzke, Mareike Uhlmann, Seesandra V Rajagopala, Manfred Koegl, Boulet Hélène, Koegl, Manfred, Susanne M Bailer, Trey Ideker, Baiker, Armin, Fossum, Even, Zeretzke, Christine, Peter Uetz, Schmidt Tina, Koegl Manfred, Thorsten Stellberger, Hélène Boulet, Kraus Theo, Armin Baiker, Tina Schmidt, Ideker, Trey, Koszinowski, Ulrich, Sourav Bandyopadhyay, Suthram Silpa, Björn Titz, Boulet, Hélène, Koszinowski Ulrich, Rajagopala, Seesandra V., Caroline C Friedel, Bailer, Susanne M, Rajagopala, Seesandra V, Dong Yu-An, Even Fossum, Bandyopadhyay Sourav, Bailer, Susanne M., Uhlmann, Mareike, Haas, Jürgen G., Ulrich Koszinowski, Uhlmann Mareike, Uetz Peter, Zimmer Ralf, Christiane Rutenberg, Friedel, Caroline C., Friedel, Caroline C, Titz, Björn, Koszinowski, Ulrich H., Rajagopala Seesandra V., Titz, Bjoern, Haas, Juergen, Ideker Trey, Albrecht von Brunn, Suthram, Silpa, Zeretzke Christine, Rutenberg, Christiane, Kraus, Theo, Jürgen Haas, Friedel Caroline C., Stellberger, Thorsten, Theo Kraus, Yu-An Dong, Rose Dietlind, Fossum Even, Uetz, Peter, von Brunn Albrecht   +79 more
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DNA-Mediated Stack Formation of Nanodiscs

Molecules, 2021
Membrane-scaffolding proteins (MSPs) derived from apolipoprotein A-1 have become a versatile tool in generating nano-sized discoidal membrane mimetics (nanodiscs) for membrane protein research.
Madhumalar Subramanian, Charlotte Kielar, Satoru Tsushima, Karim Fahmy, Jana Oertel   +4 more
doaj   +1 more source

CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]

, 2018
Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry, Hendershot, Linda M., Feige, Matthias J., Ineke Braakman, Matthias J. Feige, Braakman, Ineke, Cellular Protein Chemistry, Linda M. Hendershot   +7 more
core   +1 more source

The role of Cysteine 227 in subcellular localization, water permeability, and multimerization of aquaporin-11

FEBS Open Bio, 2014
Aquaporin-11 (AQP11) is the latest member of the mammalian water channel protein family to be described. Recent in vivo studies have shown that mutation at Cys227 causes renal failure.
Saki Takahashi, Kanako Muta, Hiroko Sonoda, Ayaka Kato, Ahmed Abdeen, Masahiro Ikeda   +5 more
doaj   +1 more source

Dynamics of HIV-1 assembly and release. [PDF]

, 2009
Assembly and release of human immunodeficiency virus (HIV) occur at the plasma membrane of infected cells and are driven by the Gag polyprotein. Previous studies analyzed viral morphogenesis using biochemical methods and static images, while dynamic and ...
Kräusslich Hans-Georg, Barbara Müller, William J. Godinez, Bräuchle Christoph, Müller, Barbara, Rohr Karl, Karl Rohr, Godinez, William J., William J Godinez, Lampe Marko, Eils, Roland, Godinez William J., Roland Eils, Rohr, Karl, Lampe, Marko, Ivanchenko Sergey, Lamb, Don C., Don C. Lamb, Marko Lampe, Bräuchle, Christoph, Eils Roland, Lamb Don C., Hans-Georg Kräusslich, Christoph Bräuchle, Kräusslich, Hans-Georg, Sergey Ivanchenko, Ivanchenko, Sergey, Don C Lamb, Müller Barbara   +28 more
core   +2 more sources

The Vesicle-inducing Protein 1 from Synechocystis sp. PCC 6803 Organizes into Diverse Higher-Ordered Ring Structures [PDF]

, 2009
The vesicle-inducing protein in plastids 1 (Vipp1) was found to be involved in thylakoid membrane formation in chloroplasts and cyanobacteria. In contrast to chloroplasts, it has been suggested that in cyanobacteria the protein is only tightly associated
Schneider, Dirk,, Rupprecht, Eva, Bultema, Jelle B., Kahmann, Uwe, Rupprecht, Eva,, Fuhrmann, Eva,, Schneider, Dirk, Fuhrmann, Eva, Boekema, Egbert J., Bultema, Jelle B.,, Kahmann, Uwe,, Boekema, Egbert J.,   +11 more
core   +2 more sources

The Evolution of Multimeric Protein Assemblages [PDF]

Molecular Biology and Evolution, 2011
Although the mechanisms by which complex cellular features evolve constitute one of the great unsolved problems of evolutionary biology, it is clear that the emergence of new protein-protein interactions, often accompanied by the diversification of duplicate genes, is involved.
openaire   +2 more sources

Statistical Models of the Protein Fitness Landscape: Applications to Protein Evolution and Engineering [PDF]

, 2012
Understanding the protein fitness landscape is important for describing how natural proteins evolve and for engineering new proteins with useful properties.
Romero, Philip Anthony
core   +1 more source