Results 11 to 20 of about 3,377,935 (215)
Cells, 2023 Previous studies have shown that BmSPI39, a serine protease inhibitor of silkworm, can inhibit virulence-related proteases and the conidial germination of insect pathogenic fungi, thereby enhancing the antifungal capacity of Bombyx mori.
Youshan Li +7 more
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Cell Reports: Methods, 2022 Summary: Tau protein aggregates are a defining neuropathological feature of “tauopathies,” a group of neurodegenerative disorders that include Alzheimer’s disease.
Simon A. Levy +5 more
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Viruses, 2021 Apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) proteins belong to a family of deaminase proteins that can catalyze the deamination of cytosine to uracil on single-stranded DNA or/and RNA.
Xiaojiang S. Chen
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Relationship between HIV-1 Gag Multimerization and Membrane Binding
Viruses, 2022 HIV-1 viral particle assembly occurs specifically at the plasma membrane and is driven primarily by the viral polyprotein Gag. Selective association of Gag with the plasma membrane is a key step in the viral assembly pathway, which is traditionally ...
Christopher Sumner, Akira Ono
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Cell Death and Disease, 2022 Transient receptor potential melastatin 8 (TRPM8) functions as a Ca2+-permeable channel in the plasma membrane (PM). Dysfunction of TRPM8 is associated with human pancreatic cancer and several other diseases in clinical patients, but the underlying ...
Yuan Huang +15 more
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Increase in cysteine-mediated multimerization under attractive protein–protein interactions
, 2022 The CASPON enzyme became an interesting enzyme for fusion protein processing because it generates an authentic N-terminus. However, the high cysteine content of the CASPON enzyme may induce aggregation via disulfide-bond formation, which can reduce ...
Tomás Mesurado (14306958) +3 more
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A tyrosine residue on the TSH receptor stabilizes multimer formation. [PDF]
PLoS ONE, 2010 The thyrotropin stimulating hormone receptor (TSHR) is a G protein coupled receptor (GPCR) with a large ectodomain. The ligand, TSH, acting via this receptor regulates thyroid growth and thyroid hormone production and secretion.
Rauf Latif +3 more
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Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis. [PDF]
PLoS ONE, 2012 The BCL-2 family protein BAK is a key regulator of mitochondrial apoptosis. BAK activation first involves N-terminal conformational changes that lead to the transient exposure of the BAK BH3 domain that then inserts into a hydrophobic groove on another ...
Abul Azad +3 more
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The effect of exon 7 deletion during the evolution of TRIMCyp fusion proteins on viral restriction, cytoplasmic body formation and multimerization. [PDF]
PLoS ONE, 2015 TRIMCyp is a fusion protein consisting of the TRIM5 gene product and retrotransposed Cyclophilin A (CypA). Two primate TRIMCyp fusion proteins with varying anti-HIV-1 activities independently evolved in owl monkeys and Old World monkeys. In addition, Old
Feng Liang Liu +5 more
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Studying protein-protein interactions using peptide arrays [PDF]
, 2010 Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T. +7 more
core +1 more source