Results 11 to 20 of about 30,399 (190)
Designed protein multimerization and polymerization for functionalization of proteins. [PDF]
Biotechnol Lett, 2022 Multimeric and polymeric proteins are large biomacromolecules consisting of multiple protein molecules as their monomeric units, connected through covalent or non-covalent bonds. Genetic modification and post-translational modifications (PTMs) of proteins offer alternative strategies for designing and creating multimeric and polymeric proteins ...
Permana D, Putra HE, Djaenudin D.
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Stochastic protein multimerization, activity, and fitness. [PDF]
Phys Rev E, 2018 Many proteins assemble into homomultimeric structures, with a number of subunits that can vary substantially among phylogenetic lineages. As protein-protein interactions require productive encounters among subunits, such variation might partially be explained by variation in cellular protein abundance. Protein abundance in turn depends on the intrinsic
Hagner K, Setayeshgar S, Lynch M.
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Relationship between HIV-1 Gag Multimerization and Membrane Binding
Viruses, 2022 HIV-1 viral particle assembly occurs specifically at the plasma membrane and is driven primarily by the viral polyprotein Gag. Selective association of Gag with the plasma membrane is a key step in the viral assembly pathway, which is traditionally ...
Christopher Sumner, Akira Ono
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Cell Death and Disease, 2022 Transient receptor potential melastatin 8 (TRPM8) functions as a Ca2+-permeable channel in the plasma membrane (PM). Dysfunction of TRPM8 is associated with human pancreatic cancer and several other diseases in clinical patients, but the underlying ...
Yuan Huang +15 more
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A tyrosine residue on the TSH receptor stabilizes multimer formation. [PDF]
PLoS ONE, 2010 The thyrotropin stimulating hormone receptor (TSHR) is a G protein coupled receptor (GPCR) with a large ectodomain. The ligand, TSH, acting via this receptor regulates thyroid growth and thyroid hormone production and secretion.
Rauf Latif +3 more
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Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis. [PDF]
PLoS ONE, 2012 The BCL-2 family protein BAK is a key regulator of mitochondrial apoptosis. BAK activation first involves N-terminal conformational changes that lead to the transient exposure of the BAK BH3 domain that then inserts into a hydrophobic groove on another ...
Abul Azad +3 more
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The effect of exon 7 deletion during the evolution of TRIMCyp fusion proteins on viral restriction, cytoplasmic body formation and multimerization. [PDF]
PLoS ONE, 2015 TRIMCyp is a fusion protein consisting of the TRIM5 gene product and retrotransposed Cyclophilin A (CypA). Two primate TRIMCyp fusion proteins with varying anti-HIV-1 activities independently evolved in owl monkeys and Old World monkeys. In addition, Old
Feng Liang Liu +5 more
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Adiponutrin: A multimeric plasma protein
Biochemical and Biophysical Research Communications, 2014 The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found.
Tinnerfelt Winberg, Martin +4 more
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Quantifying Asymmetry of Multimeric Proteins
The Journal of Physical Chemistry A, 2018 A large number of proteins assemble as homooligomers. These homooligomers accomplish their function either symmetrically or asymmetrically. If asymmetry is prevalent in a structure ensemble, the asymmetric motion will occur in any of the subunits. Many computational analysis tools implicitly use ensemble averages to determine protein motions, e.g ...
Julian T. Brennecke, Bert L. de Groot
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Retrovirology, 2008 Background The formation of new infectious human immunodeficiency type 1 virus (HIV-1) mainly relies on the homo-multimerization of the viral structural polyprotein Pr55Gag and on the recruitment of host factors.
Mouland Andrew J +3 more
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