Results 1 to 10 of about 31,339 (132)

Self-Multimerization of mRNA LNP-Derived Antigen Improves Antibody Responses [PDF]

Vaccines
Background: mRNA LNP technology is now being widely applied as a highly effective vaccine platform. Antigen multimerization is a well-established approach to enhance the antibody titers and protective efficacy of several protein subunit vaccines. However,
Cody A. Despins, James Round, Lisa Dreolini, Tracy S. Lee, Scott D. Brown, Robert A. Holt   +5 more
doaj   +3 more sources

Multimerization of a rationally designed nanobody for enhanced avidity toward Aβ42 oligomers. [PDF]

Protein Sci
Abstract Alzheimer's disease affects tens of millions of people worldwide and is associated with the self‐assembly of the Aβ42 peptide into amyloid aggregates. Among the species formed during this process, soluble oligomeric intermediates are the most closely linked to neurotoxicity and are therefore an attractive target for both therapeutic and ...
Nowinska M, Suh E, Mogilevsky C, Vendruscolo M.   +3 more
europepmc   +2 more sources

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors. [PDF]

ChemMedChem
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Saccoliti F, Patacchini E, Cara E, Zarbo L, Messore A, Albano A, Ruggieri G, Madia VN, Scipione L, Costi R, Di Santo R.   +10 more
europepmc   +2 more sources

Relationship between HIV-1 Gag Multimerization and Membrane Binding

Viruses, 2022
HIV-1 viral particle assembly occurs specifically at the plasma membrane and is driven primarily by the viral polyprotein Gag. Selective association of Gag with the plasma membrane is a key step in the viral assembly pathway, which is traditionally ...
Akira Ono
exaly   +3 more sources

Multimerization through Pegylation Improves Pharmacokinetic Properties of scFv Fragments of GD2-Specific Antibodies

Molecules, 2019
Antigen-binding fragments of antibodies specific to the tumor-associated ganglioside GD2 are well poised to play a substantial role in modern GD2-targeted cancer therapies, however, rapid elimination from the body and reduced affinity compared to full ...
Roman Kholodenko, Daniel Kalinovsky, Igor Doronin   +2 more
exaly   +3 more sources

Interactions Between Hantavirus Nucleoprotein and Glycoproteins: A Quantitative Fluorescence Microscopy Study [PDF]

Viruses
Orthohantaviruses are tri-segmented negative-sense RNA viruses that can cause severe pathologies in humans. Currently, limited information exists on the molecular interactions driving orthohantavirus assembly in infected cells.
Amit Koikkarah Aji, Titas Mandal, Salvatore Chiantia   +2 more
doaj   +2 more sources

Multimerization of secretory IgA enhances antiviral activity by aggregating influenza A virus particles [PDF]

Communications Biology
Secretory immunoglobulin A (sIgA), the first line of defense against mucosal epithelial infections, is a multimer. Although multimeric sIgA shows higher antiviral activity than monomeric IgA, the mechanism underlying this enhancement and the functional ...
Koji Yamauchi, Yukiko Muramoto, Yoko Fujita-Fujiharu, Ai Hirabayashi, Chiharu Nogami, Tsubasa Ishida, Yukihiko Sugita, Shinji Saito, Kaori Sano, Tadaki Suzuki, Masahiro Nakano, Takeshi Noda   +11 more
doaj   +2 more sources

Melinjo-derived Gnetin C restores metabolic balance via dual adipose and hepatic effects in high-fat diet mice [PDF]

Scientific Reports
Multi-organ regulation underlies metabolic health, especially in the context of adipose-liver dysfunction during obesity. Previous findings identified Melinjo seed extract (MSE) as a promising modulator of metabolic disorders, although its active ...
Tomoki Kishimoto, Aoi Nasu, Mai Uemura, Keisuke Kawano, Choyo Ogasawara, Ayami Fukuyama, Hirofumi Nohara, Ryunosuke Nakashima, Noriki Takahashi, Yukio Fujiwara, Tomoki Ikuta, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto   +13 more
doaj   +2 more sources

FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites [PDF]

Cell Reports
Summary: FoxP3, the master regulator of Tregs, employs two DNA-binding modes to recognize diverse DNA sequences. It multimerizes on long TnG repeats (n = 2–5) to bridge DNA segments and stabilize chromatin loops, and it forms head-to-head (H-H) dimers on
Fangwei Leng, Ryan Clark, Wenxiang Zhang, Thibault Viennet, Cuidie Wang, Haribabu Arthanari, Xi Wang, Sun Hur   +7 more
doaj   +2 more sources

The N-Terminal α-Helix of Potato Virus X-Encoded RNA-Dependent RNA Polymerase Is Required for Membrane Association and Multimerization

Viruses, 2022
Positive-sense single-stranded RNA viruses replicate in virus-induced membranous organelles for maximum efficiency and immune escaping. The replication of potato virus X (PVX) takes place on the endoplasmic reticulum (ER); however, how PVX-encoded RNA ...
Xue Jiang, Yameng Luan, Mengzhu Chai, Yingshuai Yang, Yuting Wang, Wenjia Deng, Yonggang Li, Xiaofei Cheng, Xiaoyun Wu   +8 more
doaj   +1 more source