Results 41 to 50 of about 38,467 (245)

Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance

Nature Communications, 2020
Aggregate-like biomolecular assemblies are emerging as new conformational states with functionality. Aire, a transcription factor essential for central T cell tolerance, forms large aggregate-like assemblies visualized as nuclear foci.
Yu-San Huoh, Bin Wu, Sehoon Park, D. Yang, Kushagra Bansal, Emily Greenwald, Wesley P. Wong, D. Mathis, S. Hur   +8 more
semanticscholar   +1 more source

Multimerization of Zika Virus-NS5 causes ciliopathy and forces premature neurogenesis

Cell Stem Cell, 2020
SUMMARY Zika virus (ZikV) is a flavivirus that infects neural tissues, causing congenital microcephaly. ZikV has evolved multiple mechanisms to restrict proliferation and enhance cell death, although the underlying cellular events involved remain unclear.
Murielle Saade, D. Ferrero, José Blanco-Ameijeiras, Elena Gonzalez-Gobartt, M. Flores-Mendez, V. M. Ruiz-Arroyo, E. Martínez-Sáez, S. Cajal, Naiara Akizu, Nuria Verdaguer, Elisa Martí   +10 more
semanticscholar   +1 more source

Optimized Solid Phase-Assisted Synthesis of Dendrons Applicable as Scaffolds for Radiolabeled Bioactive Multivalent Compounds Intended for Molecular Imaging

Molecules, 2014
Dendritic structures, being highly homogeneous and symmetric, represent ideal scaffolds for the multimerization of bioactive molecules and thus enable the synthesis of compounds of high valency which are e.g., applicable in radiolabeled form as ...
Gabriel Fischer, Björn Wängler, Carmen Wängler   +2 more
doaj   +1 more source

Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins

bioRxiv, 2020
Receptor binding studies using recombinant SARS-CoV proteins have been hampered due to challenges in approaches creating spike protein or domains thereof, that recapitulate receptor binding properties of native viruses.
K. Bouwman, Ilhan Tomris, H. Turner, Roosmarijn van der Woude, Tatiana M. Shamorkina, Gerlof P. Bosman, B. Rockx, S. Herfst, J. Snijder, B. Haagmans, A. Ward, G. Boons, R. D. de Vries   +12 more
semanticscholar   +1 more source

Theranostic Value of Multimers: Lessons Learned from Trimerization of Neurotensin Receptor Ligands and Other Targeting Vectors

Pharmaceuticals, 2017
Neurotensin receptor 1 (NTS1) is overexpressed on a variety of cancer entities; for example, prostate cancer, ductal pancreatic adenocarcinoma, and breast cancer.
Simone Maschauer, Jürgen Einsiedel, Dominik Reich, Harald Hübner, Peter Gmeiner, Hans-Jürgen Wester, Olaf Prante, Johannes Notni   +7 more
doaj   +1 more source

Multimerization of Staufen1 in live cells [PDF]

RNA, 2010
Transport of mRNA is an efficient mechanism to target proteins to specific regions of a cell. Although it is well documented that mRNAs are transported in ribonucleoprotein (RNP) complexes, several of the mechanisms involved in complex formation and localization are poorly understood.
Catherine, Martel, Samuel, Dugré-Brisson, Karine, Boulay, Billy, Breton, Gabriel, Lapointe, Sylvain, Armando, Véronique, Trépanier, Thomas, Duchaîne, Michel, Bouvier, Luc, Desgroseillers   +9 more
openaire   +2 more sources

A facile approach for the in vitro assembly of multimeric membrane transport proteins

eLife, 2018
Membrane proteins such as ion channels and transporters are frequently homomeric. The homomeric nature raises important questions regarding coupling between subunits and complicates the application of techniques such as FRET or DEER spectroscopy.
Erika A Riederer, Paul J Focke, Elka R Georgieva, Nurunisa Akyuz, Kimberly Matulef, Peter P Borbat, Jack H Freed, Scott C Blanchard, Olga Boudker, Francis I Valiyaveetil   +9 more
doaj   +1 more source

The LCK-14-3-3ζ-TRPM8 axis regulates TRPM8 function/assembly and promotes pancreatic cancer malignancy

Cell Death and Disease, 2022
Transient receptor potential melastatin 8 (TRPM8) functions as a Ca2+-permeable channel in the plasma membrane (PM). Dysfunction of TRPM8 is associated with human pancreatic cancer and several other diseases in clinical patients, but the underlying ...
Yuan Huang, Shi Li, Qinfeng Liu, Zhijie Wang, Shunyao Li, Lei Liu, Weiwei Zhao, Kai Wang, Rui Zhang, Longfei Wang, Ming Wang, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang   +15 more
doaj   +1 more source

Insights into the Structures and Multimeric Status of APOBEC Proteins Involved in Viral Restriction and Other Cellular Functions

Viruses, 2021
Apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) proteins belong to a family of deaminase proteins that can catalyze the deamination of cytosine to uracil on single-stranded DNA or/and RNA.
Xiaojiang S. Chen
doaj   +1 more source

Adiponutrin: A multimeric plasma protein

Biochemical and Biophysical Research Communications, 2014
The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found.
Tinnerfelt Winberg, Martin, Khalaj Motlagh, Mahshid, Stenkula, Karin, Holm, Cecilia, Jones, Helena   +4 more
openaire   +3 more sources