Results 41 to 50 of about 32,835 (232)
Biomolecules, 2018 Cell-penetrating peptides (CPPs) are typically prone to endocytic uptake into human cells. However, they are often inefficient at escaping from endosomes, which limits their ability to deliver cargos into cells.
Jason K. Allen +3 more
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Pharmaceuticals, 2018 The inverse electron-demand Diels-Alder reaction between 1,2,4,5-tetrazine (Tz) and trans-cyclooct-2-ene (TCO) has gained increasing attraction among extensive studies on click chemistry due to its exceptionally fast reaction kinetics and high ...
Dominik Summer +7 more
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New Insights Into Retroviral Gag-Gag and Gag-Membrane Interactions
Frontiers in Microbiology, 2014 A critical aspect of viral replication is the assembly of virus particles, which aresubsequently released as progeny virus. While a great deal of attention has beenfocused on better understanding this phase of the viral life cycle, many aspects of ...
Jose eMaldonado +4 more
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Molecules, 2014 Dendritic structures, being highly homogeneous and symmetric, represent ideal scaffolds for the multimerization of bioactive molecules and thus enable the synthesis of compounds of high valency which are e.g., applicable in radiolabeled form as ...
Gabriel Fischer +2 more
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Structure and Function of Multimeric G-quadruplexes [PDF]
Molecules, 2019 G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine tetrads. They are frequently used as building blocks and functional elements in fields such as synthetic biology and also thought to play widespread biological roles.
Sofia Kolesnikova, Edward A. Curtis
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Pharmaceuticals, 2017 Neurotensin receptor 1 (NTS1) is overexpressed on a variety of cancer entities; for example, prostate cancer, ductal pancreatic adenocarcinoma, and breast cancer.
Simone Maschauer +7 more
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Cell Death and Disease, 2022 Transient receptor potential melastatin 8 (TRPM8) functions as a Ca2+-permeable channel in the plasma membrane (PM). Dysfunction of TRPM8 is associated with human pancreatic cancer and several other diseases in clinical patients, but the underlying ...
Yuan Huang +15 more
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Viruses, 2021 Apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) proteins belong to a family of deaminase proteins that can catalyze the deamination of cytosine to uracil on single-stranded DNA or/and RNA.
Xiaojiang S. Chen
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A facile approach for the in vitro assembly of multimeric membrane transport proteins
eLife, 2018 Membrane proteins such as ion channels and transporters are frequently homomeric. The homomeric nature raises important questions regarding coupling between subunits and complicates the application of techniques such as FRET or DEER spectroscopy.
Erika A Riederer +9 more
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Transcription of multimeric tRNA genes
Nucleic Acids Research, 1984 We have constructed a set of plasmids carrying a tRNAPro gene from C. elegans in a head to tail dimeric and trimeric arrangement with virtually no spacer sequence. We show that in two different transcriptional systems, each coding region functions as an internal promoter directing the synthesis of independent transcriptional products.
G, Ciliberto, C, Traboni, R, Cortese
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