Results 51 to 60 of about 32,835 (232)
Multimerization of HIV proteins.
, 2014 *Bolded residues are known multimerization inhibitors.
Ray Matti (543812) +30 more
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A tyrosine residue on the TSH receptor stabilizes multimer formation. [PDF]
PLoS ONE, 2010 The thyrotropin stimulating hormone receptor (TSHR) is a G protein coupled receptor (GPCR) with a large ectodomain. The ligand, TSH, acting via this receptor regulates thyroid growth and thyroid hormone production and secretion.
Rauf Latif +3 more
doaj +1 more source
Isothermal Amplification and Multimerization of DNA by Bst DNA polymerase
, 2001 We have demonstrated the isothermal in vitro amplification and multimerization of several different linear DNA targets using only two primers and the strongly strand-displacing exonuclease-negative Bst DNA polymerase. This reaction has been termed linear
L.C. Wolter +9 more
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The Evolution of Multimeric Protein Assemblages [PDF]
Molecular Biology and Evolution, 2011 Although the mechanisms by which complex cellular features evolve constitute one of the great unsolved problems of evolutionary biology, it is clear that the emergence of new protein-protein interactions, often accompanied by the diversification of duplicate genes, is involved.
openaire +2 more sources
Frontiers in Microbiology, 2019 Current anti-hepatitis B virus (HBV) agents, which include nucleos(t)ide analogs and interferons, can significantly suppress HBV infection. However, there are limitations in the therapeutic efficacy of these agents, indicating the need to develop anti ...
Kento Fukano +16 more
doaj +1 more source
HIV-1 Rev multimerization: mechanism and insights
, 2013 To export intron-containing viral mRNAs that encode the structural components of new viral particles from the nucleus to the cytoplasm, HIV-1 uses the cellular CRM1 export pathway that is exploited by the viral Rev protein.
Daelemans, Dirk, Vercruysse, Thomas
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Frontiers in Neuroscience, 2018 α-Synuclein (αS) is a conserved and abundant neuronal protein with unusual structural properties. It appears to partition between folded and unstructured states as well as between membrane-bound and aqueously soluble states. In addition, a switch between
Ulf Dettmer
doaj +1 more source
, 2006 A major goal in antibody design for cancer therapy is to tailor the pharmacokinetic properties of the molecule according to specific treatment requirements. Key parameters determining the pharmacokinetics of therapeutic antibodies are target specificity,
Zangemeister-Wittke, Uwe +9 more
core +1 more source
Multimerization improves targeting of peptide radio-pharmaceuticals
, 2012 Multimerization offers unique kinetic and thermodynamic properties to molecules. Multimeric ligands, characterized by multiple similar or different monomeric molecules tethered together, can bind several receptors simultaneously.
Ananias, Hildo J. K. +11 more
core +2 more sources
Molecules, 2019 Antigen-binding fragments of antibodies specific to the tumor-associated ganglioside GD2 are well poised to play a substantial role in modern GD2-targeted cancer therapies, however, rapid elimination from the body and reduced affinity compared to full ...
Irina V. Kholodenko +9 more
doaj +1 more source