Results 71 to 80 of about 38,467 (245)

Investigation of HIV-1 Gag binding with RNAs and lipids using Atomic Force Microscopy.

PLoS ONE, 2020
Atomic Force Microscopy was utilized to study the morphology of Gag, ΨRNA, and their binding complexes with lipids in a solution environment with 0.1Å vertical and 1nm lateral resolution. TARpolyA RNA was used as a RNA control. The lipid used was phospha-
Shaolong Chen, Jun Xu, Mingyue Liu, A L N Rao, Roya Zandi, Sarjeet S Gill, Umar Mohideen   +6 more
doaj   +1 more source

A Broad-Spectrum Antiviral Molecule, Protoporphyrin IX, Acts as a Moderator of HIV-1 Capsid Assembly by Targeting the Capsid Hexamer

Microbiology Spectrum, 2023
The capsid protein (CA), an essential component of human immunodeficiency virus type 1 (HIV-1), represents an appealing target for antivirals. Small molecules targeting the CAI-binding cavity in the C-terminal domain of HIV-1 CA (CA CTD) confer potent ...
Da-Wei Zhang, Liangxu Xie, Xiao-Shuang Xu, Yimin Li, Xiaojun Xu   +4 more
doaj   +1 more source

The BTB/POZ‐MATH Protein ZmBPM1 Interacts With Autophagy‐related Protein ZmATG6 and Modulates the NLR Protein Rp1‐D21‐Mediated Defense Response in Maize

Advanced Science, EarlyView.
The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Chang‐Xiao Tang, Tong‐Tong Liu, Qi‐Dong Ge, Xiao‐Ying Liu, Wanxiao Wang, Yang Sun, Yanfei Liu, Faqiang Li, Guan‐Feng Wang   +8 more
wiley   +1 more source

Functional Characterization of the VWF p.Cys2163Tyr Variant Reveals Impaired Secretion and Intracellular Processing

Biomolecules
Von Willebrand disease (VWD) is the most common inherited bleeding disorder, yet the contribution of specific VWF domains to its pathogenesis remains incompletely understood.
Yuxin Zhang, Yingkun Zhang, Aizhen Yang, Yabei Zuo, Xiaofeng Yan, Feifei Zhang, Yan Wang, Zhiyun Niu, Fengwu Chen, Yi Wu, Jingyu Zhang   +10 more
doaj   +1 more source

Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis. [PDF]

PLoS ONE, 2012
The BCL-2 family protein BAK is a key regulator of mitochondrial apoptosis. BAK activation first involves N-terminal conformational changes that lead to the transient exposure of the BAK BH3 domain that then inserts into a hydrophobic groove on another ...
Abul Azad, Joanna Fox, Sabrina Leverrier, Alan Storey   +3 more
doaj   +1 more source

Diverging Liquid–Liquid Phase Separation Behavior of Different Recombinant Major Ampullate Spidroins

Advanced Science, EarlyView.
Fibers spun from the MaSp1‐derivative as well as MaSp1‐MaSp2‐mixtures provide a deeper insight into the assembly process of the spidroins and how hierarchical architectures of spider silk fibers could be achieved. ABSTRACT Spider silk fibers show exceptional mechanical properties, based on their underlying spider silk proteins (spidroins) as well as a ...
Tim Schiller, Cheryl Hayashi, Thomas R. Scheibel   +2 more
wiley   +1 more source

The effect of exon 7 deletion during the evolution of TRIMCyp fusion proteins on viral restriction, cytoplasmic body formation and multimerization. [PDF]

PLoS ONE, 2015
TRIMCyp is a fusion protein consisting of the TRIM5 gene product and retrotransposed Cyclophilin A (CypA). Two primate TRIMCyp fusion proteins with varying anti-HIV-1 activities independently evolved in owl monkeys and Old World monkeys. In addition, Old
Feng Liang Liu, Yi Qun Kuang, Dan Mu, Hong Yi Zheng, Jia Wu Zhu, Yong Tang Zheng   +5 more
doaj   +1 more source

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Microtubule-Driven Multimerization Recruits ase1p onto Overlapping Microtubules [PDF]

, 2008
Microtubule (MT) crosslinking proteins of the ase1p/PRC1/Map65 family play a major role in the construction of MT networks such as the mitotic spindle. Most homologs in this family have been shown to localize with a remarkable specificity to sets of MTs ...
van den Wildenberg, Siet M. J. L., Hoogenraad, C., Hoogenraad, C.C., Janson, Marcel E., Schmidt, Christoph F., van den Wildenberg, SMJL, Peterman, EJG, Kapitein, Lukas C., Kapitein, L.C., Wildenberg, S.M.J.L., van den, Janson, M.E., Schmidt, C., van den Wildenberg, S.M.J.L., Peterman, E.J.G., Peterman, Erwin J.G., Janson, ME, Schmidt, C.F., Wildenberg, S.M.J.L., Hoogenraad, Casper C., Hoogenraad, CC, Peterman, Erwin J. G., Schmidt, CF, Kapitein, Lukas, van den Wildenberg, Siet M.J.L., Schmidt, Christoph   +24 more
core   +1 more source