Results 61 to 70 of about 38,467 (245)

Essential role of N-terminal SAM regions in STIM1 multimerization and function

Proceedings of the National Academy of Sciences of the United States of America
Significance In this study, we unravel the elusive endoplasmic reticulum (ER)-luminal multimerization region of Stromal Interaction Molecule 1 (STIM1), a pivotal regulator of store-operated calcium homeostasis.
Matthias Sallinger, Christina Humer, H. L. Ong, Sasirekha Narayanasamy, Qi-Tong Lin, M. Fahrner, H. Grabmayr, Sascha Berlansky, Sean Choi, Tony Schmidt, Lena Maltan, Lara Atzgerstorfer, Martin Niederwieser, I. Frischauf, C. Romanin, P. Stathopulos, I. Ambudkar, R. Leitner, D. Bonhenry, R. Schindl   +19 more
semanticscholar   +1 more source

PEGylation and multimerization of the anti-p185HER-2 single chain Fv fragment 4D5: effects on tumor targeting

, 2006
A major goal in antibody design for cancer therapy is to tailor the pharmacokinetic properties of the molecule according to specific treatment requirements. Key parameters determining the pharmacokinetics of therapeutic antibodies are target specificity,
Zangemeister-Wittke, Uwe, Andreas Plückthun, Kubetzko, Susanne, Uwe Zangemeister-Wittke, Robert Waibel, Plückthun, Andreas, Waibel, Robert, Ela Balic, Balic, Ela, Susanne Kubetzko   +9 more
core   +1 more source

Multimerization improves targeting of peptide radio-pharmaceuticals

, 2012
Multimerization offers unique kinetic and thermodynamic properties to molecules. Multimeric ligands, characterized by multiple similar or different monomeric molecules tethered together, can bind several receptors simultaneously.
Ananias, Hildo J. K., de Jong, Igle J.; id_orcid, Dierckx, Rudi, de Jong, Igle J., Carlucci, Giuseppe, Yu, Zilin, Elsinga, Philip H., Ananias, Hildo JK, Elsinga, Philippus, de Jong, Igle J, Dierckx, Rudi A., Van De Wiele, Christophe   +11 more
core   +2 more sources

Rationally Designed Variants of α-Synuclein Illuminate Its in vivo Structural Properties in Health and Disease

Frontiers in Neuroscience, 2018
α-Synuclein (αS) is a conserved and abundant neuronal protein with unusual structural properties. It appears to partition between folded and unstructured states as well as between membrane-bound and aqueously soluble states. In addition, a switch between
Ulf Dettmer
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2

Molecular Biomedicine, 2020
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of a potentially fatal disease named coronavirus disease 2019 (COVID-19), has raised significant public health concerns globally.
Changhui Zhang, Yi-Ping Chen, Li Li, Yan Yang, Jun He, Cheng Chen, D. Su   +6 more
semanticscholar   +1 more source

Disulfide-Linked Head-to-Head Multimerization in the Mechanism of Ion Channel Clustering by PSD-95 [PDF]

, 1997
The PSD-95/SAP90 family of PDZ-containing proteins is directly involved in the clustering of specific ion channels at synapses. We report that channel clustering depends on a conserved N-terminal domain of PSD-95 that mediates multimerization and ...
Hsueh, Yi-Ping, Kim, Eunjoon, Sheng, Morgan   +2 more
core   +2 more sources

Conformational Switching of Proteins on Material Surfaces Enabled by Peptide‐Oriented Adsorption

Advanced Functional Materials, EarlyView.
Responsive biointerfaces could be achieved using conformationally responsive proteins; however, their interconversion can be lost upon surface adsorption. Herein, we demonstrate that the incorporation a Au binding peptide into calmodulin allows for binding control on Au wherein the protein retains conformational switching. This capability was confirmed
Sakthirupini Ramamurthy, Kyle B. Meerbott, Lorenzo Travaglini, Garima S. Dobhal, Artur Sawicki, Marc R. Knecht, Tiffany R. Walsh, Dominic J. Glover   +7 more
wiley   +1 more source

SIZ1‐Mediated SUMOylation of LBD29 Recruits ARF7 to Fine‐Tune Auxin Signaling in Lateral Root Development

Advanced Science, EarlyView.
Our findings establish SUMOylation as a key post‐translational control layer in auxin signaling. We show that SIZ1‐mediated SUMOylation of LBD29 promotes its association with ARF7, stabilizing a transcriptional hub that governs lateral root development.
Jiaxuan Sui, Qianlan Yin, Yiying Chen, Liping Zhang, Xiuyuan Yu, Qianqian Yu, Zhaojun Ding, Xiangpei Kong   +7 more
wiley   +1 more source

Thiol-mediated and catecholamine-enhanced multimerization of a cerebrovascular disease enriched fragment of NOTCH3

Experimental Neurology, 2020
Cerebral small vessel disease is a common condition linked to dementia and stroke. As an age-dependent brain pathology, cerebral SVD may share molecular processes with core neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.
K. Young, N. Cartee, M. Ivanova, Michael M. Wang   +3 more
semanticscholar   +1 more source