Results 61 to 70 of about 32,835 (232)

Enhanced Carbapenem Resistance through Multimerization of Plasmids Carrying Carbapenemase Genes

mBio, 2021
We demonstrated the multimerization of plasmids harboring carbapenemase genes, and multimeric plasmids of various discrete sizes existed in a host bacterial cell of Escherichia ...
Ryuichiro Abe, Yukihiro Akeda, Yo Sugawara, Yuki Matsumoto, Daisuke Motooka, Ryuji Kawahara, Norihisa Yamamoto, Kazunori Tomono, Tetsuya Iida, Shigeyuki Hamada   +9 more
doaj   +1 more source

Evidence for the multimeric structure of ferroportin

Blood, 2006
Abstract Ferroportin (Fpn) (IREG1, SLC40A1, MTP1) is an iron transporter, and mutations in Fpn result in a genetically dominant form of iron overload disease. Previously, we demonstrated that Fpn is a multimer and that mutations in Fpn are dominant negative.
I. DE DOMENICO, D. MCVEY WARD, MUSCI, Giovanni, J. KAPLAN   +3 more
openaire   +4 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Diffusion Coefficient and Viscosity of Methyl Viologen Electrolyte Estimation Based on a Kinetic Monte Carlo Computational Approach Coupled with the Mean Square Displacement Method

Batteries &Supercaps, Volume 8, Issue 3, March 2025.
A novel and comprehensive 3D‐resolved kinetic Monte Carlo model coupled with mean square displacement analysis is introduced. This computational approach allows to explore, for the first time, the concentration and the state of charge effects on ionic diffusion coefficient and viscosity in methyl viologen‐based electrolytes used in organic redox flow ...
Jia Yu, Emmanuel Baudrin, Alejandro A. Franco   +2 more
wiley   +1 more source

Investigation of HIV-1 Gag binding with RNAs and lipids using Atomic Force Microscopy.

PLoS ONE, 2020
Atomic Force Microscopy was utilized to study the morphology of Gag, ΨRNA, and their binding complexes with lipids in a solution environment with 0.1Å vertical and 1nm lateral resolution. TARpolyA RNA was used as a RNA control. The lipid used was phospha-
Shaolong Chen, Jun Xu, Mingyue Liu, A L N Rao, Roya Zandi, Sarjeet S Gill, Umar Mohideen   +6 more
doaj   +1 more source

Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis. [PDF]

PLoS ONE, 2012
The BCL-2 family protein BAK is a key regulator of mitochondrial apoptosis. BAK activation first involves N-terminal conformational changes that lead to the transient exposure of the BAK BH3 domain that then inserts into a hydrophobic groove on another ...
Abul Azad, Joanna Fox, Sabrina Leverrier, Alan Storey   +3 more
doaj   +1 more source

A Broad-Spectrum Antiviral Molecule, Protoporphyrin IX, Acts as a Moderator of HIV-1 Capsid Assembly by Targeting the Capsid Hexamer

Microbiology Spectrum, 2023
The capsid protein (CA), an essential component of human immunodeficiency virus type 1 (HIV-1), represents an appealing target for antivirals. Small molecules targeting the CAI-binding cavity in the C-terminal domain of HIV-1 CA (CA CTD) confer potent ...
Da-Wei Zhang, Liangxu Xie, Xiao-Shuang Xu, Yimin Li, Xiaojun Xu   +4 more
doaj   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Redox-regulated Aux/IAA multimerization modulates auxin responses [PDF]

International audienceReactive oxygen species function as key signals in plant adaptation to environmental stresses like drought. Roots respond to transient water unavailability by temporarily ceasing branching through the acclimative response ...
Mullineaux, Phil, Bennett, Malcolm J, Lilley, Kathryn, Brown, Adrian, Bhagat, Prakash Kumar, Vermeer, Joop E M, Ingole, Kishor, Vermeer, Joop, Bechtold, Ulrike, Clark, Lisa, Mukkawar, Vaishnavi, Roy, Dipan, Vernoux, Teva, Vermeer, Joop E.M., Bennett, Malcolm J., Bennett, Malcolm, Jones, Andrew, Sadanandom, Ari, Ingole, Kishor D, Mehra, Poonam, Sue-Ob, Kawinnat, Bellande, Kevin, Ghosh, Srayan, Martin-Arevalillo, Raquel, Ingole, Kishor D.   +24 more
core   +1 more source