Results 81 to 90 of about 32,835 (232)
Breaking symmetry in multimeric ATPase motors [PDF]
Cell Cycle, 2014 The ATPases associated with various cellular activities (AAA+ ATPases) form a broad family of multimeric ATP-driven motors that are ubiquitous and perform a vast variety of functions in living cells. These ATPases form ring-shaped structures with catalytic sites created in the interface between 2 neighboring motor subunits.
Sysoeva, Tatyana A +2 more
openaire +2 more sources
VIEW, EarlyView.Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley +1 more source
Acta Neuropathologica Communications, 2021 Background Multimerization is a key process in prion-like disorders such as Alzheimer’s disease (AD), since it is a requirement for self-templating tau and beta-amyloid amyloidogenesis.
Nora Bengoa-Vergniory +7 more
doaj +1 more source
Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape
The FEBS Journal, EarlyView.The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto +9 more
wiley +1 more source
Multimeric Arrays of the Yeast Retrotransposon Ty [PDF]
Molecular and Cellular Biology, 1990 We have identified a novel integrated form of the yeast retrotransposon Ty consisting of multiple elements joined into large arrays. These arrays were first identified among Ty-induced alpha-pheromone-resistant mutants of MATa cells of Saccharomyces cerevisiae which contain Ty insertions at HML alpha that result in the expression of that normally ...
K G, Weinstock +4 more
openaire +2 more sources
An update on the landscape of collagen bioactive fragments
The FEBS Journal, EarlyView.The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley +1 more source
Plug-and-play nucleic acid-mediated multimerization of biparatopic nanobodies for molecular imaging
Molecular Therapy: Nucleic AcidsIn cancer molecular imaging, selecting binders with high specificity and affinity for biomarkers is paramount for achieving high-contrast imaging within clinical time frames.
Laura Teodori +11 more
doaj +1 more source
Towards an integrated molecular understanding of plant hormones
Journal of Integrative Plant Biology, EarlyView.This review offers a comprehensive overview of the nine plant hormones, delving into their biosynthesis, transport, signaling and crosstalk mechanisms. Because the complexity of plant hormonal control goes beyond these core elements, additional specific features are discussed. Lastly, this review highlights how fundamental insights drive hormonal‐based
Louise Vilain +2 more
wiley +1 more source
Modulation of Glycan Detection on Specific Glycoproteins by Lectin Multimerization
, 2016 Improved methods for studying glycans could spur significant advances in the understanding and application of glycobiology. The use of affinity reagents such as lectins and glycan-binding antibodies is a valuable complement to methods involving mass ...
Brian B. Haab (190091) +7 more
core +1 more source
BioChemBackground/Objectives: N-Myristoyltransferase inhibitors (NMTi) represent a novel antiviral strategy against mammarenaviruses such as Lassa and Junin viruses.
Haydar Witwit, Juan C. de la Torre
doaj +1 more source