Results 91 to 100 of about 32,835 (232)

Chain‐Length Regulation by WzzE Is Necessary for, but Genetically Separable From, Cyclic Enterobacterial Common Antigen Synthesis

Molecular Microbiology, EarlyView.
Here, we demonstrate that polysaccharide chain length regulation plays a distinct role in enabling formation of a cyclic molecule important for the bacterial cell surface. However, this function is necessary, but not sufficient for the cyclic molecule's biosynthesis.
Joseph F. Carr, Yohannes H. Rezenom, Jennifer S. Rudolf, Daniel J. Warzecha, Angela M. Mitchell   +4 more
wiley   +1 more source

Technologies for engineering repetitive DNA

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley   +1 more source

A subset of high‐grade sarcomas with myogenic differentiation are associated with recurrent FGFR fusions

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Recurrent fusions involving FGFR1‐4 genes have been previously described in rare subsets of mostly benign chondroid and mesenchymal neoplasms involving bone and soft tissue. However, a more comprehensive analysis of sarcomas associated with FGFR fusions, including their incidence and histotypes, has not been performed.
Maximus CF Yeung, Carla Saoud, Sarah Chiang, Meera Hameed, Cristina R Antonescu   +4 more
wiley   +1 more source

Microtubule-Driven Multimerization Recruits ase1p onto Overlapping Microtubules

, 2008
Microtubule (MT) crosslinking proteins of the ase1p/PRC1/Map65 family play a major role in the construction of MT networks such as the mitotic spindle. Most homologs in this family have been shown to localize with a remarkable specificity to sets of MTs ...
van den Wildenberg, Siet M. J. L., Hoogenraad, C., Hoogenraad, C.C., Janson, Marcel E., Schmidt, Christoph F., van den Wildenberg, SMJL, Peterman, EJG, Kapitein, Lukas C., Kapitein, L.C., Wildenberg, S.M.J.L., van den, Janson, M.E., Schmidt, C., van den Wildenberg, S.M.J.L., Peterman, E.J.G., Peterman, Erwin J.G., Janson, ME, Schmidt, C.F., Wildenberg, S.M.J.L., Hoogenraad, Casper C., Hoogenraad, CC, Peterman, Erwin J. G., Schmidt, CF, Kapitein, Lukas, van den Wildenberg, Siet M.J.L., Schmidt, Christoph   +24 more
core   +1 more source

Monitoring α‐synuclein multimerization in vivo

The FASEB Journal, 2018
ABSTRACT The pathophysiology of Parkinson's disease is characterized by the abnormal accumulation of α‐synuclein (α‐Syn), eventually resulting in the formation of Lewy bodies and neurites in surviving neurons in the brain. Although α‐Syn aggregation has been extensively studied in vitro
Prasad V, Wasser Y, Hans F, Goswami A, Katona I, Outeiro TF, Kahle PJ, Schulz JB, Voigt A   +8 more
openaire   +6 more sources

Using generalized quantitative structure–property relationship (QSPR) models to predict host cell protein retention in ion‐exchange chromatography

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 7, Page 1420-1428, July 2026.
Abstract BACKGROUND Selecting an optimal chromatography resin during biopharmaceutical downstream process development is a great challenge. This is especially the case for recombinant subunit vaccines, where product properties vary greatly and recovery often involves cell lysis, which yields a complex mixture of different host cell materials. Host cell
Tim Neijenhuis, Olivier Le Bussy, Geoffroy Geldhof, Marieke E Klijn, Marcel Ottens   +4 more
wiley   +1 more source

PRDM9 forms a trimer by interactions within the zinc finger array

Life Science Alliance, 2019
PRDM9 forms a trimer as a soluble protein and in complex with DNA mediated by the ZnF domain. Five ZnFs are already sufficient for multimerization and only one DNA molecule is complexed in the trimer.
Theresa Schwarz, Yasmin Striedner, Andreas Horner, Karin Haase, Jasmin Kemptner, Nicole Zeppezauer, Philipp Hermann, Irene Tiemann-Boege   +7 more
doaj   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, Volume 46, Issue 4, Page 921-944, July 2026.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

Dynamics of Apolipoprotein J Levels and Metabolic Parameters Following Bariatric Surgery

Clinical Endocrinology, Volume 105, Issue 1, Page 42-50, July 2026.
ABSTRACT Objective Bariatric surgery has emerged as a potent intervention for ameliorating insulin resistance and its associated comorbidities in obese patients. Apolipoprotein J (ApoJ) and adiponectin are closely associated with insulin resistance and sensitivity, respectively.
Kellen Cristina da Cruz Rodrigues, Minjin Lee, Yejee Lim, Jennie Young, Brendon Chung, Susan Phillips, Theodore P. Ciaraldi, Young‐Bum Kim   +7 more
wiley   +1 more source

Zinc-dependent multimerization of mutant calreticulin is required for MPL binding and MPN pathogenesis.

, 2021
Calreticulin (CALR) is mutated in the majority of JAK2/MPL-unmutated myeloproliferative neoplasms (MPNs). Mutant CALR (CALRdel52) exerts its effect by binding to the thrombopoietin receptor MPL to cause constitutive activation of JAK-STAT signaling.
Chen, Edwin, Boyd, G., Alameer, G, Laslo, P, Boxall, Sally A, Rivera, Jeanne F, Boyd, G, Jackson, BR, Boyd, Grace, Mullally, A., Jackson, Brian R, Rivera, JF, Kent, DG, Baxter, E.J., Baxter, EJ, Kent, David Geoffrey, Alameer, G., Nadat, F., Laslo, P., Chen, E, Mullally, Ann, Chen, E., Green, AR, Burman, E.L., Green, A.R., Burman, EL, Smyth, R, Nadat, Fatima, Smyth, R., Patel, H., Burman, Emma L, Mullally, A, Nadat, F, Patel, H, Kent, D.G., Boxall, SA, Baral, A.J., Baral, AJ, Patel, Hershna, Baral, April J, Jackson, B.R., Baxter, Joanna, Smyth, Rachael, Alameer, Ghadah, Boxall, S.A., Green, Anthony R, Rivera, J.F., Laslo, Peter   +47 more
core   +1 more source