Results 111 to 120 of about 38,467 (245)
Technologies for engineering repetitive DNA
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley +1 more source
Transcription of multimeric tRNA genes
Nucleic Acids Research, 1984 We have constructed a set of plasmids carrying a tRNAPro gene from C. elegans in a head to tail dimeric and trimeric arrangement with virtually no spacer sequence. We show that in two different transcriptional systems, each coding region functions as an internal promoter directing the synthesis of independent transcriptional products.
G, Ciliberto, C, Traboni, R, Cortese
openaire +3 more sources
mAbs, 2017 Immunostimulatory receptors belonging to the tumor necrosis factor receptor (TNFR) superfamily are emerging as promising targets for cancer immunotherapies.
Di Zhang +6 more
semanticscholar +1 more source
Scientific Reports, 2018 APOBEC3H (A3H) is a member of the APOBEC3 subfamily of DNA cytosine deaminases that are important for innate immune defense and have been implicated in cancer biogenesis.
Fumiaki Ito +7 more
semanticscholar +1 more source
Scientific Reports, 2016 Transmission-blocking vaccines (TBV) target the sexual-stages of the malaria parasite in the mosquito midgut and are widely considered to be an essential tool for malaria elimination.
Yuanyuan Li +13 more
semanticscholar +1 more source
ROS responsive Aux/IAA multimerization modulates auxin responses
Reactive oxygen species (ROS) function as key signals in plants to enable adaptation to environmental stresses. Plant roots respond to transient water stress by temporarily ceasing branching using the acclimative response xerobranching 1 . In this study,
Mullineaux, Phil +15 more
core +1 more source
Depletion of cellular cholesterol inhibits membrane binding and higher-order multimerization of human immunodeficiency virus type 1 Gag [PDF]
, 2007 Recent studies have suggested that the plasma membrane contains cholesterol-enriched microdomains known as lipid rafts. HIV-1 Gag binds raft-rich regions of the plasma membrane, and cholesterol depletion impairs HIV-1 particle production.
Ono, Akira +2 more
core +1 more source
HU multimerization shift controls nucleoid compaction
Science Advances, 2016 HU networks control chromatin-like DNA compaction to synchronize bacterial responses for pathogenesis and changing environments. Molecular mechanisms controlling functional bacterial chromosome (nucleoid) compaction and organization are surprisingly ...
M. Hammel +8 more
semanticscholar +1 more source
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
eLife, 2019 Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN.
Pratibha C Koneru +14 more
doaj +1 more source
Multimerization rules for G-quadruplexes
Nucleic Acids Research, 2017 G-quadruplexes can multimerize under certain conditions, but the sequence requirements of such structures are not well understood. In this study, we investigated the ability of all possible variants of the central tetrad in a monomeric, parallel-strand G-
S. Kolesnikova +4 more
semanticscholar +1 more source