Results 111 to 120 of about 32,835 (232)
Multimerization of peptide antigens for production of stable immunogens in transgenic plants
, 2007 Previous literature addressing the production of recombinant proteins in heterologous systems has consistently shown that proteins capable of forming complex structures tend to accumulate within host cells at relatively higher levels than monomeric forms.
Reytor, Edel +3 more
core +1 more source
Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.Plasminogen is a circulating zymogen that is converted into active plasmin by plasminogen activators such as tissue plasminogen activator (tPA) and urokinase‐type PA (uPA). This conversion is regulated by plasminogen activator inhibitors (PAI‐1, PAI‐2) and by inhibitors of plasmin itself, maintaining a fine balance between activation and inhibition of ...
Bernard Perbal
wiley +1 more source
Homotypic Interaction and Multimerization of Hepatitis C Virus Core Protein
, 1996 Hepatitis C virus (HCV) core protein constitutes a viral nucleocapsid and may possess multiple functions. In this study, we demonstrated the homotypic interaction and multimerization of HCV core proteinin vitroandin vivo.By using a yeast two-hybrid ...
JENG, KING-SONG +4 more
core +1 more source
TREM-1 multimerization is essential for its activation on monocytes and neutrophils [PDF]
, 2018 The triggering receptor expressed on myeloid cells-1 (TREM-1) is a receptor expressed on innate immune cells. By promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors (TLRs), TREM-1 has been characterized
Wang, Guanbo +25 more
core +1 more source
Multimerization of polyomavirus middle-T antigen
Journal of Virology, 1997 The oncogenic protein of polyomavirus, middle-T antigen, associated with cell membranes and interacts with a variety of cellular proteins involved in mitogenic signalling. Middle-T antigen may therefore mimic the function of cellular tyrosine kinase growth factor receptors, like the platelet-derived growth factor or epidermal growth factor receptor ...
Senften M, Dilworth S, Ballmer-Hofer K
openaire +3 more sources
Multiplexed Retinoic Acid Signal Reporters for In Vivo and In Vitro Use
genesis, Volume 64, Issue 3, June 2026.ABSTRACT Here we describe the optimisation of a modular, generally applicable and rapid method to make multimerised signaling‐molecule reporters for detecting different retinoic acid concentrations. The technical plasmid design allows for the easy exchange of reporters, promoters, signal‐responsive elements as well as for the multimerization of entire ...
Craig Smith +4 more
wiley +1 more source
Multimerization of Solution-State Proteins by Tetrakis(4-sulfonatophenyl)porphyrin
, 2016 Surface binding and interactions of anionic porphyins bound to cationic proteins have been studied for nearly three decades and are relevant as models for protein surface molecular recognition and photoinitiated electron transfer. However, interpretation
David M. Tiede (1275405) +4 more
core +1 more source
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
eLife, 2019 Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN.
Pratibha C Koneru +14 more
doaj +1 more source
European Journal of Immunology, Volume 56, Issue 6, June 2026.Inducing memory inflation (MI) is a promising future vaccination strategy. We show that spread‐defective cytomegalovirus does not induce MI in the absence of CD4+ T cells. Support from CD4+ T cells can drive effector differentiation of MI cells, even late in the response, and contributes to long‐term response maintenance. ABSTRACT Memory inflation (MI)
Jack Barton +6 more
wiley +1 more source
Multimerization and interaction of Toll and Spatzle in Drosophila
, 2009 The Toll family of receptors is required for innate immune response to pathogen-associated molecules, but the mechanism of signaling is not entirely clear.
Ip, Y. Tony +4 more
core +1 more source