Results 121 to 130 of about 38,467 (245)

The Evolution of Multimeric Protein Assemblages [PDF]

Molecular Biology and Evolution, 2011
Although the mechanisms by which complex cellular features evolve constitute one of the great unsolved problems of evolutionary biology, it is clear that the emergence of new protein-protein interactions, often accompanied by the diversification of duplicate genes, is involved.
openaire   +2 more sources

A quantitative IN subunit exchange assay specifically illustrates multimerization defect of IN dimeric interface mutants.

, 2013
(A) Mechanics of the subunit exchange assay for quantifying HIV-1 IN multimerization. Mutant IN was expressed with a 6x Histidine tag, while WT IN was expressed with a GST tag.
Wannes Thys (307258), Jonas Demeulemeester (180282), Zeger Debyser (20227), Laith Q. Al-Mawsawi (307260), Erik Serrao (307256), Frauke Christ (180292), Nouri Neamati (275633)   +6 more
core   +1 more source

The oncogenic fusion protein EML4-NTRK3 requires three salt bridges for stability and biological activity

Heliyon
Aim of study: Chromosomal translocations involving neurotrophic receptor tyrosine kinases (NTRKs) have been identified in 20 % of soft tissue sarcomas. This work focuses on the EML4-NTRK3 translocation identified in cases of Infantile Fibrosarcoma, which
Zian Jiang, April N. Meyer, Wei Yang, Daniel J. Donoghue   +3 more
doaj   +1 more source

Adipocyte XBP1s regulates systemic insulin sensitivity by modulating adiponectin multimerization

, 2013
The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown.
Wang, Anping, Liu, Feng, Qi, Ling, Sha, Haibo, Yang, L., Kersten, Sander   +5 more
core  

Multimerization of Solution-State Proteins by Tetrakis(4-sulfonatophenyl)porphyrin

, 2016
Surface binding and interactions of anionic porphyins bound to cationic proteins have been studied for nearly three decades and are relevant as models for protein surface molecular recognition and photoinitiated electron transfer. However, interpretation
David M. Tiede (1275405), Oleksandr Kokhan (1395433), P. Raj Pokkuluri (621128), Nina Ponomarenko (1617988), Marianne Schiffer (10580)   +4 more
core   +1 more source

Multimerization and interaction of Toll and Spatzle in Drosophila

, 2009
The Toll family of receptors is required for innate immune response to pathogen-associated molecules, but the mechanism of signaling is not entirely clear.
Ip, Y. Tony, Zhou, Sili L., Hu, Xiaodi, Yagi, Yoshimasa, Tanji, Takahiro   +4 more
core   +1 more source

YaeT-independent multimerization and outer membrane association of secretin PulD

, 2007
Previous studies demonstrated that targeting of the dodecameric secretin PulD to the Escherichia coli outer membrane is strictly dependent on the chaperone-like pilotin PulS.
Chami, Mohamed, Collin, Séverine, Guilvout, Ingrid, Pugsley, Anthony P.   +3 more
core   +1 more source

Demonstration of a Simple Epitope Tag Multimerization Strategy for Enhancing the Sensitivity of Protein Detection Using Drosophila vAChT

G3: Genes, Genomes, Genetics, 2020
Kole V. Tison, Hannah M. McKinney, R. Steven Stowers   +2 more
doaj   +1 more source

Multimerization of HIV-1 integrase hinges on conserved SH3-docking platforms

, 2018
New anti-AIDS treatments must be continually developed in order to overcome resistance mutations including those emerging in the newest therapeutic target, the viral integrase (IN).
Akram Alian, Meytal Galilee
core   +1 more source

Optimizing the Multimerization Properties of Quinoline-Based Allosteric HIV-1 Integrase Inhibitors

Viruses
Allosteric HIV-1 Integrase (IN) Inhibitors or ALLINIs bind at the dimer interface of the IN, away from the enzymatic catalytic site, and disable viral replication by inducing over-multimerization of IN.
Jian Sun, Jacques J. Kessl
doaj   +1 more source