Results 121 to 130 of about 32,835 (232)
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng +3 more
wiley +1 more source
Adipocyte XBP1s regulates systemic insulin sensitivity by modulating adiponectin multimerization
The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown.
Wang, Anping +5 more
core
YaeT-independent multimerization and outer membrane association of secretin PulD
Previous studies demonstrated that targeting of the dodecameric secretin PulD to the Escherichia coli outer membrane is strictly dependent on the chaperone-like pilotin PulS.
Chami, Mohamed +3 more
core +1 more source
Evolutionary diversification of the multimeric states of proteins [PDF]
Significance Rather than operating as single units, most proteins assemble as multimers, usually with all subunits derived from the same gene. In contrast to patterns of gene structure and genome organization, which typically exhibit substantial increases in complexity from unicellular to multicellular organisms, the structural complexity of ...
openaire +2 more sources
Abstract Surfactant protein D (SP‐D) plays a vital role in innate immunity by recognizing and binding to glycans on the surfaces of various pathogens. The oligomerization of SP‐D into dodecameric structures enhances its pathogen‐binding and antiviral activities.
Deng Li, Mona S. Minkara
wiley +1 more source
Nanobodies: A Promising Toolkit for Diagnostic Applications
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu +11 more
wiley +1 more source
Recent studies have suggested that the plasma membrane contains cholesterol-enriched microdomains known as lipid rafts. HIV-1 Gag binds raft-rich regions of the plasma membrane, and cholesterol depletion impairs HIV-1 particle production.
Ono, Akira +2 more
core +1 more source
GPIHBP1 Missense Mutations Often Cause Multimerization of GPIHBP1 and Thereby Prevent Lipoprotein Lipase Binding [PDF]
Rationale: GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) in the subendothelial spaces and shuttles it to the capillary lumen.
Beigneux, Anne P +8 more
core +1 more source
Functional multimerization of mucolipin channel proteins
AbstractMCOLN1 encodes mucolipin‐1 (TRPML1), a member of the transient receptor potential TRPML subfamily of channel proteins. Mutations in MCOLN1 cause mucolipidosis‐type IV (MLIV), a lysosomal storage disorder characterized by severe neurologic, ophthalmologic, and gastrointestinal abnormalities.
Curcio Morelli, Cyntia +6 more
openaire +3 more sources
DNA Mold‐Based Fabrication of Continuous Silver Nanostructures
Using a DNA mold‐based approach, the growth of silver nanostructures is mediated. By optimizing the metallization protocol and applying thermal annealing, continuous metallic nanowires of several hundred nanometers in length are obtained. The conductance of these nanostructures was perturbed by atmospheric sulfur contaminations, such that precautions ...
Christoph Hadlich +7 more
wiley +1 more source

