Results 121 to 130 of about 32,835 (232)

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

open access: yesiNew Medicine, Volume 2, Issue 2, June 2026.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng   +3 more
wiley   +1 more source

Adipocyte XBP1s regulates systemic insulin sensitivity by modulating adiponectin multimerization

open access: yes, 2013
The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown.
Wang, Anping   +5 more
core  

YaeT-independent multimerization and outer membrane association of secretin PulD

open access: yes, 2007
Previous studies demonstrated that targeting of the dodecameric secretin PulD to the Escherichia coli outer membrane is strictly dependent on the chaperone-like pilotin PulS.
Chami, Mohamed   +3 more
core   +1 more source

Evolutionary diversification of the multimeric states of proteins [PDF]

open access: yesProceedings of the National Academy of Sciences, 2013
Significance Rather than operating as single units, most proteins assemble as multimers, usually with all subunits derived from the same gene. In contrast to patterns of gene structure and genome organization, which typically exhibit substantial increases in complexity from unicellular to multicellular organisms, the structural complexity of ...
openaire   +2 more sources

Investigating the structural basis of surfactant protein D oligomerization: The crucial role of Cys15‐Cys15/Cys20‐Cys20 disulfide bond linkage

open access: yesProtein Science, Volume 35, Issue 6, June 2026.
Abstract Surfactant protein D (SP‐D) plays a vital role in innate immunity by recognizing and binding to glycans on the surfaces of various pathogens. The oligomerization of SP‐D into dodecameric structures enhances its pathogen‐binding and antiviral activities.
Deng Li, Mona S. Minkara
wiley   +1 more source

Nanobodies: A Promising Toolkit for Diagnostic Applications

open access: yesSmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu   +11 more
wiley   +1 more source

Depletion of cellular cholesterol inhibits membrane binding and higher-order multimerization of human immunodeficiency virus type 1 Gag

open access: yes, 2007
Recent studies have suggested that the plasma membrane contains cholesterol-enriched microdomains known as lipid rafts. HIV-1 Gag binds raft-rich regions of the plasma membrane, and cholesterol depletion impairs HIV-1 particle production.
Ono, Akira   +2 more
core   +1 more source

GPIHBP1 Missense Mutations Often Cause Multimerization of GPIHBP1 and Thereby Prevent Lipoprotein Lipase Binding [PDF]

open access: yes, 2015
Rationale: GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) in the subendothelial spaces and shuttles it to the capillary lumen.
Beigneux, Anne P   +8 more
core   +1 more source

Functional multimerization of mucolipin channel proteins

open access: yesJournal of Cellular Physiology, 2009
AbstractMCOLN1 encodes mucolipin‐1 (TRPML1), a member of the transient receptor potential TRPML subfamily of channel proteins. Mutations in MCOLN1 cause mucolipidosis‐type IV (MLIV), a lysosomal storage disorder characterized by severe neurologic, ophthalmologic, and gastrointestinal abnormalities.
Curcio Morelli, Cyntia   +6 more
openaire   +3 more sources

DNA Mold‐Based Fabrication of Continuous Silver Nanostructures

open access: yesSmall Structures, Volume 7, Issue 6, June 2026.
Using a DNA mold‐based approach, the growth of silver nanostructures is mediated. By optimizing the metallization protocol and applying thermal annealing, continuous metallic nanowires of several hundred nanometers in length are obtained. The conductance of these nanostructures was perturbed by atmospheric sulfur contaminations, such that precautions ...
Christoph Hadlich   +7 more
wiley   +1 more source

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