Results 101 to 110 of about 38,467 (245)

The Alzheimer's disease risk gene SORL1 is a regulator of excitatory neuronal function

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Synaptic dysfunction is an early feature of Alzheimer's disease (AD) and proper localization of proteins involved in pre‐ and post‐synaptic composition is dependent on endosomal recycling and trafficking, cellular processes involving the AD risk gene sortilin‐related receptor 1 (SORL1). METHODS We examined SORL1's role in synaptic
C. Andrew Williams, Shannon E. Rose, Vera Stamenkovic, Aquene N. Reid, Kyle J. Travaglini, Stephen E. P. Smith, Jessica E. Young   +6 more
wiley   +1 more source

Mechanistic insights into the switch of αB-crystallin chaperone activity and self-multimerization

Journal of Biological Chemistry, 2018
αB-Crystallin (αBc) is a small heat shock protein that protects cells against abnormal protein aggregation and disease-related degeneration. αBc is also a major structural protein that forms polydisperse multimers that maintain the liquid-like property ...
Zhenying Liu, Chu-Chu Wang, Yi-Chen Li, Chun-Yu Zhao, Tongzhou Li, Dan Li, Shengnan Zhang, Cong Liu   +7 more
semanticscholar   +1 more source

Evidence for the multimeric structure of ferroportin

Blood, 2006
Abstract Ferroportin (Fpn) (IREG1, SLC40A1, MTP1) is an iron transporter, and mutations in Fpn result in a genetically dominant form of iron overload disease. Previously, we demonstrated that Fpn is a multimer and that mutations in Fpn are dominant negative.
I. DE DOMENICO, D. MCVEY WARD, MUSCI, Giovanni, J. KAPLAN   +3 more
openaire   +4 more sources

Modulation of Glycan Detection on Specific Glycoproteins by Lectin Multimerization

, 2016
Improved methods for studying glycans could spur significant advances in the understanding and application of glycobiology. The use of affinity reagents such as lectins and glycan-binding antibodies is a valuable complement to methods involving mass ...
Brian B. Haab (190091), Elizabeth Brouhard (1996129), Marina Hincapie (1590268), William S. Hancock (1321737), Zheng Cao (562710), Mitchell McDonald (1996123), Katie Partyka (190068), Randall E. Brand (1996126)   +7 more
core   +1 more source

Arabidopsis AUGMIN8 Contains Two Independent Microtubule Association Domains

Cytoskeleton, Volume 83, Issue 9, Page 752-767, September 2026.
ABSTRACT Plant cells create a plasma membrane‐associated network of microtubules that are nucleated by γ‐tubulin ring complexes primarily through microtubule‐dependent microtubule nucleation (MDMN). This dynamic array organizes into specific patterns in response to developmental and environmental cues to influence primary cell wall construction.
Naveen K. Chana, Timothy Cioffi, Sidney L. Shaw   +2 more
wiley   +1 more source

Hu antigen R (HuR) multimerization contributes to glioma disease progression

Journal of Biological Chemistry, 2017
Among primary brain cancers, gliomas are the most deadly and most refractory to current treatment modalities. Previous reports overwhelmingly support the role of the RNA-binding protein Hu antigen R (HuR) as a positive regulator of glioma disease ...
N. Filippova, Xiu-Hua Yang, S. Ananthan, A. Sorochinsky, J. Hackney, Z. Gentry, S. Bae, P. H. King, L. Nabors   +8 more
semanticscholar   +1 more source

Homotypic Interaction and Multimerization of Hepatitis C Virus Core Protein [PDF]

, 1996
Hepatitis C virus (HCV) core protein constitutes a viral nucleocapsid and may possess multiple functions. In this study, we demonstrated the homotypic interaction and multimerization of HCV core proteinin vitroandin vivo.By using a yeast two-hybrid ...
JENG, KING-SONG, ZHU, NONGLIAO, MATSUMOTO, MASAYUKI, HWANG, SOON B., LAI, MICHAEL M.C.   +4 more
core   +1 more source

PRDM9 forms a trimer by interactions within the zinc finger array

Life Science Alliance, 2019
PRDM9 forms a trimer as a soluble protein and in complex with DNA mediated by the ZnF domain. Five ZnFs are already sufficient for multimerization and only one DNA molecule is complexed in the trimer.
Theresa Schwarz, Yasmin Striedner, Andreas Horner, Karin Haase, Jasmin Kemptner, Nicole Zeppezauer, Philipp Hermann, Irene Tiemann-Boege   +7 more
doaj   +1 more source

No Significant Secondary Structural Change of α‐Synuclein Monomer by Site‐Specific DOPA or Phosphorylation Introduction in Its C‐Terminal Region

Journal of Peptide Science, Volume 32, Issue 9, September 2026.
Site‐specifically modified α‐synuclein containing DOPA or phosphorylation was prepared by ligation of a bacterially expressed N‐terminal polypeptide and a synthetic C‐terminal modified peptide. ABSTRACT α‐Synuclein (αSyn) is a major component of pathogenic Lewy bodies and Lewy neurites and is closely associated with Parkinson's disease.
Tatsuhito Matsuo, Isao Suetake, Mariko Kimura, Satoshi Hashimoto, Koichi Matsuo, Sakiko Matsumoto, Shinji Hirotsune, Hironobu Hojo   +7 more
wiley   +1 more source

Correction of a dominant‐negative von Willebrand factor multimerization defect by small interfering RNA‐mediated allele‐specific inhibition of mutant von Willebrand factor

Journal of Thrombosis and Haemostasis, 2018
Essentials Substitution therapy for von Willebrand (VW) disease leaves mutant VW factor (VWF) unhindered. Presence of mutant VWF may negatively affect phenotypes despite treatment.
De A. S. Jong, R. Dirven, J. Oud, D. Tio, B. V. van Vlijmen, Jeroen C. J. Eikenboom   +5 more
semanticscholar   +1 more source