Results 131 to 140 of about 32,835 (232)
Exploring Apoptin’s Anticancer Ability: Uncoupling Nuclear Export and Multimerization
, 2009 Apoptin, Chicken Anemia Virus VP3, selectively induces apoptosis in transformed cells but not primary cells. In all cases, Apoptin undergoes nucleocytoplasmic shuttling, but partitions into the nucleus of transformed cells and the cytoplasm of primary ...
Tischer, Douglas K. +1 more
core
Multimerization of HIV-1 integrase hinges on conserved SH3-docking platforms
, 2018 New anti-AIDS treatments must be continually developed in order to overcome resistance mutations including those emerging in the newest therapeutic target, the viral integrase (IN).
Akram Alian, Meytal Galilee
core +1 more source
Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk
Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1722-1742, June 2026.ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin +2 more
wiley +1 more source
, 2008 The VP3 (Apoptin) protein from the Chicken Anemia Virus has been shown to selectively kill transformed cells; an activity that is dependent on subcellular localization.
Medeiros, Adam Charles +1 more
core
Journal of Neurochemistry, Volume 170, Issue 6, June 2026.Ischemic insult causes hyper‐glutamatergic signaling and neuronal death. The astrocytic transporter GLT‐1, which clears extracellular glutamate, is internalized and degraded in response to ischemia. We found that lysine‐directed post‐translational modifications (particularly ubiquitination) of the C‐terminal domain drive aberrant trafficking ...
Simran Kaur Gill +4 more
wiley +1 more source
Clathrin‐Mediated Endocytosis in Plants: Historical to Modern Advances
Traffic, Volume 27, Issue 2, June 2026.Ultrastructural studies by Bonnett and Newcomb in 1966 revealed the existence of coated vesicles budding from the plant cell plasma membrane. This review introduces this discovery and early questions regarding the biological significance of CME in plants highlighting advances in our understanding of the plant CME molecular machinery along with current ...
Timber Mattson +2 more
wiley +1 more source
HeliyonAim of study: Chromosomal translocations involving neurotrophic receptor tyrosine kinases (NTRKs) have been identified in 20 % of soft tissue sarcomas. This work focuses on the EML4-NTRK3 translocation identified in cases of Infantile Fibrosarcoma, which
Zian Jiang +3 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 10, 27 May 2026.A comparison of two structurally related prostate specific membrane antigen (PSMA)‐targeted fluorophores revealed that the substitution of the urea motif lysine‐urea‐glutamate (KuE) by a phosphinate leads to probes with low nanomolar PSMA‐affinity, good and specific tumor uptake, and low off‐target tissue retention in mice.
Lennart F. V. Spickschen +10 more
wiley +1 more source
Construction of a CO2‐Fixing Compartment Using a Shape‐Transforming DNA Scaffold
Chemistry – A European Journal, Volume 32, Issue 19, 22 May 2026.A shape‐transforming DNA scaffold encapsulates RuBisCO within a controllable, self‐contacting compartment that mimics the carboxysome. The scaffold switches between open and closed states, enabling direct comparison of identical enzyme populations in different microenvironments.
Hui Yang +6 more
wiley +1 more source
S117 dephosphorylation is required for BAK multimerization.
, 2012 (A) Schematic representation of BAK showing the relative location of the BH domains, TM domain and α-helical regions. Location of mutations of S91 and S117 are indicated. (B) PyMol structural representation of BAK (2IMS) with the location of S91 and S117
Abul Azad (117840) +3 more
core +1 more source