Results 31 to 40 of about 32,835 (232)
Synthetic Integrin-Targeting Dextran-Fc Hybrids Efficiently Inhibit Tumor Proliferation In Vitro
Frontiers in Chemistry, 2021 Herein, we present the design, synthesis, and biological evaluation of novel integrin-targeting molecular hybrids combining RGD peptides and a potent cytotoxin presented on dextran polysaccharides. Based on an aglycosylated Fc as a centerpiece, endosomal-
Hendrik Schneider +6 more
doaj +1 more source
Multimerization of Staufen1 in live cells [PDF]
RNA, 2010 Transport of mRNA is an efficient mechanism to target proteins to specific regions of a cell. Although it is well documented that mRNAs are transported in ribonucleoprotein (RNP) complexes, several of the mechanisms involved in complex formation and localization are poorly understood.
Catherine, Martel +9 more
openaire +2 more sources
Increase in cysteine-mediated multimerization under attractive protein–protein interactions
, 2022 The CASPON enzyme became an interesting enzyme for fusion protein processing because it generates an authentic N-terminus. However, the high cysteine content of the CASPON enzyme may induce aggregation via disulfide-bond formation, which can reduce ...
Tomás Mesurado (14306958) +3 more
core +1 more source
PlyC: A multimeric bacteriophage lysin [PDF]
Proceedings of the National Academy of Sciences, 2006 Lysins are murein hydrolases produced by bacteriophage that act on the bacterial host cell wall to release progeny phage. When added extrinsically in their purified form, these enzymes produce total lysis of susceptible Gram-positive bacteria within seconds, suggesting a unique antimicrobial strategy.
Daniel, Nelson +4 more
openaire +2 more sources
Current Issues in Molecular Biology, 2023 Oligomerization of antibody fragments via modification with polyethylene glycol (pegylation) may alter their function and properties, leading to a multivalent interaction of the resulting constructs with the target antigen.
Daniel V. Kalinovsky +8 more
doaj +1 more source
Adiponutrin: A multimeric plasma protein
Biochemical and Biophysical Research Communications, 2014 The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found.
Tinnerfelt Winberg, Martin +4 more
openaire +3 more sources
Detection of Specific RNA Targets by Multimerization
Biochemistry (Moscow), 2023 Detection of specific RNA targets via amplification-mediated techniques is widely used in fundamental studies and medicine due to an essential role of RNA in realization of genetic information and diseases development. Here, we report on an approach for detection of RNA targets based on a particular type of isothermal amplification, namely, reaction of
Sakhabutdinova, Assol R. +2 more
openaire +2 more sources
Quantifying Asymmetry of Multimeric Proteins
The Journal of Physical Chemistry A, 2018 A large number of proteins assemble as homooligomers. These homooligomers accomplish their function either symmetrically or asymmetrically. If asymmetry is prevalent in a structure ensemble, the asymmetric motion will occur in any of the subunits. Many computational analysis tools implicitly use ensemble averages to determine protein motions, e.g ...
Julian T. Brennecke, Bert L. de Groot
openaire +4 more sources
Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors
Viruses, 2022 Allosteric HIV-1 integrase (IN) inhibitors, or ALLINIs, are a new class of antiviral agents that bind at the dimer interface of the IN, away from the enzymatic catalytic site and block viral replication by triggering an aberrant multimerization of the ...
Long Phi Dinh +7 more
doaj +1 more source
Multimerization rules for G-quadruplexes [PDF]
Nucleic Acids Research, 2017 G-quadruplexes can multimerize under certain conditions, but the sequence requirements of such structures are not well understood. In this study, we investigated the ability of all possible variants of the central tetrad in a monomeric, parallel-strand G-quadruplex to form higher-order structures.
Kolesnikova, S. (Sofia) +4 more
openaire +3 more sources