Results 21 to 30 of about 38,467 (245)
Dectin-1 Multimerization and Signaling Depends on Fungal β-Glucan Structure and Exposure.
Biophysical Journal, 2023 Dectin-1A is a C-type Lectin innate immunoreceptor that recognizes β-(1,3;1,6)-glucan, a structural component of Candida species cell walls. β-glucans can adopt solution structures ranging from random coil to insoluble fiber due to tertiary (helical) and
Eduardo U. Anaya +5 more
semanticscholar +1 more source
DNA-Mediated Stack Formation of Nanodiscs
Molecules, 2021 Membrane-scaffolding proteins (MSPs) derived from apolipoprotein A-1 have become a versatile tool in generating nano-sized discoidal membrane mimetics (nanodiscs) for membrane protein research.
Madhumalar Subramanian +4 more
doaj +1 more source
FOXP3 recognizes microsatellites and bridges DNA through multimerization
Nature, 2023 FOXP3 uses the forkhead domain to form a higher-order multimer after binding to T_ n G repeat microsatellites. FOXP3 is a transcription factor that is essential for the development of regulatory T cells, a branch of T cells that suppress excessive ...
Wenxiang Zhang +6 more
semanticscholar +1 more source
Structural basis of von Willebrand factor multimerization and tubular storage
Blood, 2022 The von Willebrand factor (VWF) propeptide (domains D1D2) is essential for the assembly of VWF multimers and its tubular storage in Weibel-Palade bodies. However, detailed molecular mechanism underlying this propeptide dependence is unclear.
Jian-Wei Zeng +6 more
semanticscholar +1 more source
Data in Brief, 2020 This article reports experimental data related to the research article entitled “Prevention of DNA multimerization using phosphoryl guanidine primers during isothermal amplification with Bst exo- DNA polymerase” (R.R. Garafutdinov, A.R. Sakhabutdinova, M.
Ravil R. Garafutdinov +3 more
doaj +1 more source
Cell Reports: Methods, 2022 Summary: Tau protein aggregates are a defining neuropathological feature of “tauopathies,” a group of neurodegenerative disorders that include Alzheimer’s disease.
Simon A. Levy +5 more
doaj +1 more source
Synthetic Integrin-Targeting Dextran-Fc Hybrids Efficiently Inhibit Tumor Proliferation In Vitro
Frontiers in Chemistry, 2021 Herein, we present the design, synthesis, and biological evaluation of novel integrin-targeting molecular hybrids combining RGD peptides and a potent cytotoxin presented on dextran polysaccharides. Based on an aglycosylated Fc as a centerpiece, endosomal-
Hendrik Schneider +6 more
doaj +1 more source
International Journal on Biological Sciences, 2022 The activation of the GATA-binding factor 4 (GATA4) transcription factor induces cardiac hypertrophy and heart failure. The multimerization of transcription factors often plays an important role in the regulation of transcriptional activity.
Satoshi Shimizu +10 more
semanticscholar +1 more source
Thrombosis Journal, 2021 Background Type 3 von Willebrand disease (VWD) exhibits severe hemorrhagic tendency with complicated pathogenesis. The C-terminal cystine knot (CTCK) domain plays an important role in the dimerization and secretion of von Willebrand factor (VWF).
Yuxin Zhang +7 more
doaj +1 more source
RNA multimerization as an organizing force for liquid–liquid phase separation
RNA: A publication of the RNA Society, 2021 RNA interactions are exceptionally strong and highly redundant. As such, nearly any two RNAs have the potential to interact with one another over relatively short stretches, especially at high RNA concentrations. This is especially true for pairs of RNAs
P. Bevilacqua +3 more
semanticscholar +1 more source