Results 21 to 30 of about 32,835 (232)

FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites [PDF]

Cell Reports
Summary: FoxP3, the master regulator of Tregs, employs two DNA-binding modes to recognize diverse DNA sequences. It multimerizes on long TnG repeats (n = 2–5) to bridge DNA segments and stabilize chromatin loops, and it forms head-to-head (H-H) dimers on
Fangwei Leng, Ryan Clark, Wenxiang Zhang, Thibault Viennet, Cuidie Wang, Haribabu Arthanari, Xi Wang, Sun Hur   +7 more
doaj   +2 more sources

Molecular basis for multimerization in the activation of the epidermal growth factor receptor [PDF]

eLife, 2016
The epidermal growth factor receptor (EGFR) is activated by dimerization, but activation also generates higher-order multimers, whose nature and function are poorly understood. We have characterized ligand-induced dimerization and multimerization of EGFR
Yongjian Huang, Shashank Bharill, Deepti Karandur, Sean M Peterson, Morgan Marita, Xiaojun Shi, Megan J Kaliszewski, Adam W Smith, Ehud Y Isacoff, John Kuriyan   +9 more
doaj   +2 more sources

The role of Cysteine 227 in subcellular localization, water permeability, and multimerization of aquaporin-11

FEBS Open Bio, 2014
Aquaporin-11 (AQP11) is the latest member of the mammalian water channel protein family to be described. Recent in vivo studies have shown that mutation at Cys227 causes renal failure.
Saki Takahashi, Kanako Muta, Hiroko Sonoda, Ayaka Kato, Ahmed Abdeen, Masahiro Ikeda   +5 more
doaj   +2 more sources

TIA-1 Self-Multimerization, Phase Separation, and Recruitment into Stress Granules Are Dynamically Regulated by Zn2+

Cell Reports, 2018
Summary: Stress granules are non-membranous structures that transiently form in the cytoplasm during cellular stress, where they promote translational repression of non-essential RNAs and modulate cell signaling by sequestering key signal transduction ...
Joseph B. Rayman, Kevin A. Karl, Eric R. Kandel   +2 more
doaj   +3 more sources

Peptide Multimerization as Leads for Therapeutic Development

Biologics, 2021
Multimerization of peptide structures has been a logical evolution in their development as potential therapeutic molecules. The multivalent properties of these assemblies have attracted much attention from researchers in the past and the development of ...
Dean E. Sheard, Wenyi Li, Neil M. O’Brien-Simpson, Frances Separovic, John D. Wade   +4 more
doaj   +1 more source

DNA-Mediated Stack Formation of Nanodiscs

Molecules, 2021
Membrane-scaffolding proteins (MSPs) derived from apolipoprotein A-1 have become a versatile tool in generating nano-sized discoidal membrane mimetics (nanodiscs) for membrane protein research.
Madhumalar Subramanian, Charlotte Kielar, Satoru Tsushima, Karim Fahmy, Jana Oertel   +4 more
doaj   +1 more source

The N-Terminal α-Helix of Potato Virus X-Encoded RNA-Dependent RNA Polymerase Is Required for Membrane Association and Multimerization

Viruses, 2022
Positive-sense single-stranded RNA viruses replicate in virus-induced membranous organelles for maximum efficiency and immune escaping. The replication of potato virus X (PVX) takes place on the endoplasmic reticulum (ER); however, how PVX-encoded RNA ...
Xue Jiang, Yameng Luan, Mengzhu Chai, Yingshuai Yang, Yuting Wang, Wenjia Deng, Yonggang Li, Xiaofei Cheng, Xiaoyun Wu   +8 more
doaj   +1 more source

The disulfide bond Cys2724-Cys2774 in the C-terminal cystine knot domain of von Willebrand factor is critical for its dimerization and secretion

Thrombosis Journal, 2021
Background Type 3 von Willebrand disease (VWD) exhibits severe hemorrhagic tendency with complicated pathogenesis. The C-terminal cystine knot (CTCK) domain plays an important role in the dimerization and secretion of von Willebrand factor (VWF).
Yuxin Zhang, Fengwu Chen, Aizhen Yang, Xiaoying Wang, Yue Han, Depei Wu, Yi Wu, Jingyu Zhang   +7 more
doaj   +1 more source

TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy

Cell Reports: Methods, 2022
Summary: Tau protein aggregates are a defining neuropathological feature of “tauopathies,” a group of neurodegenerative disorders that include Alzheimer’s disease.
Simon A. Levy, Gabrielle Zuniga, Elias M. Gonzalez, David Butler, Sally Temple, Bess Frost   +5 more
doaj   +1 more source

Data on multimerization efficiency for short linear DNA templates and phosphoryl guanidine primers during isothermal amplification with Bst exo- DNA polymerase

Data in Brief, 2020
This article reports experimental data related to the research article entitled “Prevention of DNA multimerization using phosphoryl guanidine primers during isothermal amplification with Bst exo- DNA polymerase” (R.R. Garafutdinov, A.R. Sakhabutdinova, M.
Ravil R. Garafutdinov, Assol R. Sakhabutdinova, Maxim S. Kupryushkin, Dmitrii V. Pyshnyi   +3 more
doaj   +1 more source