Results 11 to 20 of about 32,835 (232)
The multimerization pathway of the glucocorticoid receptor. [PDF]
Nucleic Acids ResAbstract The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conformation of full-length GR (FL-GR), which is key for its biological activity, remains disputed.
Alegre-Martí A +18 more
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Self-Multimerization of mRNA LNP-Derived Antigen Improves Antibody Responses [PDF]
VaccinesBackground: mRNA LNP technology is now being widely applied as a highly effective vaccine platform. Antigen multimerization is a well-established approach to enhance the antibody titers and protective efficacy of several protein subunit vaccines. However,
Cody A. Despins +5 more
doaj +3 more sources
Interactions Between Hantavirus Nucleoprotein and Glycoproteins: A Quantitative Fluorescence Microscopy Study [PDF]
VirusesOrthohantaviruses are tri-segmented negative-sense RNA viruses that can cause severe pathologies in humans. Currently, limited information exists on the molecular interactions driving orthohantavirus assembly in infected cells.
Amit Koikkarah Aji +2 more
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Relationship between HIV-1 Gag Multimerization and Membrane Binding
Viruses, 2022 HIV-1 viral particle assembly occurs specifically at the plasma membrane and is driven primarily by the viral polyprotein Gag. Selective association of Gag with the plasma membrane is a key step in the viral assembly pathway, which is traditionally ...
Christopher Sumner, Akira Ono
doaj +2 more sources
Induced Fit in Protein Multimerization: The HFBI Case. [PDF]
PLoS Computational Biology, 2016 Hydrophobins, produced by filamentous fungi, are small amphipathic proteins whose biological functions rely on their unique surface-activity properties.
Laura Riccardi, Paolo Mereghetti
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Cells, 2023 Previous studies have shown that BmSPI39, a serine protease inhibitor of silkworm, can inhibit virulence-related proteases and the conidial germination of insect pathogenic fungi, thereby enhancing the antifungal capacity of Bombyx mori.
Youshan Li +7 more
doaj +2 more sources
Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
Signal Transduction and Targeted Therapy, 2023 Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, safeguarding receptor activation, and facilitating amplification of signal transduction across the cellular membrane.
Yan Sun +15 more
doaj +2 more sources
Melinjo-derived Gnetin C restores metabolic balance via dual adipose and hepatic effects in high-fat diet mice [PDF]
Scientific ReportsMulti-organ regulation underlies metabolic health, especially in the context of adipose-liver dysfunction during obesity. Previous findings identified Melinjo seed extract (MSE) as a promising modulator of metabolic disorders, although its active ...
Tomoki Kishimoto +13 more
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A new class of multimerization selective inhibitors of HIV-1 integrase. [PDF]
PLoS Pathogens, 2014 The quinoline-based allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are promising candidates for clinically useful antiviral agents. Studies using these compounds have highlighted the role of IN in both early and late stages of virus replication ...
Amit Sharma +12 more
doaj +2 more sources
Multimerization: Closed or open association scenario?
The European Physical Journal E, 2005 We address the problem of classification of the type of association (multimerization) in solutions of identical unimers. Although the aggregation is still routinely characterized in terms of either "open association" or "closed association" models, neither of the two models can provide a fair description of many aggregation processes.
I A, Nyrkova, A N, Semenov
openaire +3 more sources