Results 11 to 20 of about 38,467 (245)
Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
Signal Transduction and Targeted Therapy, 2023 Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, safeguarding receptor activation, and facilitating amplification of signal transduction across the cellular membrane.
Yan Sun +15 more
doaj +3 more sources
Molecular basis for multimerization in the activation of the epidermal growth factor receptor [PDF]
eLife, 2016 The epidermal growth factor receptor (EGFR) is activated by dimerization, but activation also generates higher-order multimers, whose nature and function are poorly understood. We have characterized ligand-induced dimerization and multimerization of EGFR
Yongjian Huang +9 more
doaj +3 more sources
Peptide Multimerization as Leads for Therapeutic Development
Biologics, 2021 Multimerization of peptide structures has been a logical evolution in their development as potential therapeutic molecules. The multivalent properties of these assemblies have attracted much attention from researchers in the past and the development of ...
Dean E. Sheard +4 more
doaj +2 more sources
Redox-regulated Aux/IAA multimerization modulates auxin responses. [PDF]
ScienceReactive oxygen species function as key signals in plant adaptation to environmental stresses like drought. Roots respond to transient water unavailability by temporarily ceasing branching through the acclimative response xerobranching. In this study, we
Dipan Roy +18 more
semanticscholar +2 more sources
Induced Fit in Protein Multimerization: The HFBI Case. [PDF]
PLoS Computational Biology, 2016 Hydrophobins, produced by filamentous fungi, are small amphipathic proteins whose biological functions rely on their unique surface-activity properties.
Laura Riccardi, Paolo Mereghetti
doaj +2 more sources
Cells, 2023 Previous studies have shown that BmSPI39, a serine protease inhibitor of silkworm, can inhibit virulence-related proteases and the conidial germination of insect pathogenic fungi, thereby enhancing the antifungal capacity of Bombyx mori.
Youshan Li +7 more
doaj +2 more sources
Enhanced Carbapenem Resistance through Multimerization of Plasmids Carrying Carbapenemase Genes
mBio, 2021 We demonstrated the multimerization of plasmids harboring carbapenemase genes, and multimeric plasmids of various discrete sizes existed in a host bacterial cell of Escherichia ...
Ryuichiro Abe +9 more
doaj +2 more sources
The multimerization pathway of the glucocorticoid receptor. [PDF]
Nucleic Acids ResAbstract The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conformation of full-length GR (FL-GR), which is key for its biological activity, remains disputed.
Alegre-Martí A +18 more
europepmc +9 more sources
A new class of multimerization selective inhibitors of HIV-1 integrase. [PDF]
PLoS Pathogens, 2014 The quinoline-based allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are promising candidates for clinically useful antiviral agents. Studies using these compounds have highlighted the role of IN in both early and late stages of virus replication ...
Amit Sharma +12 more
doaj +2 more sources
Cell Reports, 2018 Summary: Stress granules are non-membranous structures that transiently form in the cytoplasm during cellular stress, where they promote translational repression of non-essential RNAs and modulate cell signaling by sequestering key signal transduction ...
Joseph B. Rayman +2 more
doaj +2 more sources