Results 1 to 10 of about 1,078,004 (272)

Coronavirus genomic RNA packaging [PDF]

Virology, 2019
RNA viruses carry out selective packaging of their genomes in a variety of ways, many involving a genomic packaging signal. The first coronavirus packaging signal was discovered nearly thirty years ago, but how it functions remains incompletely understood.
Paul S Masters
exaly   +4 more sources

Identification of the SARS-CoV-2 genome packaging signal in the nsp12-coding region [PDF]

Nature Communications
Selective genome packaging is a critical step for RNA viruses, which must distinguish genomic RNA from other abundant transcripts. For SARS-CoV-2, the cis-acting packaging signal is thought to be recognized by the nucleocapsid (N) protein, but its ...
Youngran Park, Jongmin Lim, Hyeonggon Cho, Ahyeon Son, Minseok Jeong, Young-suk Lee, V. Narry Kim   +6 more
doaj   +2 more sources

Involvement of 5′ and 3′ UTRs in SARS-CoV-2 Virus-like Particle Genome Packaging [PDF]

Viruses
The molecular mechanisms governing the efficient packaging of the large SARS-CoV-2 RNA genome into progeny virions remain incompletely understood, with the role of untranslated regions (UTRs) being particularly enigmatic.
Zhang Zhang, Kun Yang, Fangze Shao, Wenlong Shen, Ping Li, Yue Zhang, Junjie Xu, Dejian Xie, Chudong Wang, Guoying Yu, Jun Zhang, Zhihu Zhao, Yan Zhang   +12 more
doaj   +2 more sources

Identification of the initial nucleocapsid recognition element in the HIV-1 RNA packaging signal [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2020
Siarhei Kharytonchyk, Alice Telesnitsky, Alexis Waller   +2 more
exaly   +2 more sources

The curious case of genome packaging and assembly in RNA viruses infecting plants

Frontiers in Genetics, 2023
Genome packaging is the crucial step for maturation of plant viruses containing an RNA genome. Viruses exhibit a remarkable degree of packaging specificity, despite the probability of co-packaging cellular RNAs.
Tushar Ranjan, Ravi Ranjan Kumar, Mohammad Ansar, Jitesh Kumar, Auroshikha Mohanty, Anamika Kumari, Khushbu Jain, Kumari Rajani, Sailabala Dei, Mohammad Feza Ahmad   +9 more
doaj   +1 more source

Plasma Membrane Anchoring and Gag:Gag Multimerization on Viral RNA Are Critical Properties of HIV-1 Gag Required To Mediate Efficient Genome Packaging

mBio, 2021
Human immunodeficiency virus type 1 (HIV-1) Gag selects and packages the HIV RNA genome during virus assembly. However, HIV-1 RNA constitutes only a small fraction of the cellular RNA.
Alice Duchon, Steven Santos, Jianbo Chen, Matthew Brown, Olga A. Nikolaitchik, Sheldon Tai, Jeffrey A. Chao, Eric O. Freed, Vinay K. Pathak, Wei-Shau Hu   +9 more
doaj   +1 more source

HIV-1 Packaging Visualised by In-Gel SHAPE

Viruses, 2021
HIV-1 packages two copies of its gRNA into virions via an interaction with the viral structural protein Gag. Both copies and their native RNA structure are essential for virion infectivity.
Aaron R. D’Souza, Dhivya Jayaraman, Ziqi Long, Jingwei Zeng, Liam J. Prestwood, Charlene Chan, Dennis Kappei, Andrew M. L. Lever, Julia C. Kenyon   +8 more
doaj   +1 more source

Disruption of Specific RNA-RNA Interactions in a Double-Stranded RNA Virus Inhibits Genome Packaging and Virus Infectivity. [PDF]

PLoS Pathogens, 2015
Bluetongue virus (BTV) causes hemorrhagic disease in economically important livestock. The BTV genome is organized into ten discrete double-stranded RNA molecules (S1-S10) which have been suggested to follow a sequential packaging pathway from smallest ...
Teodoro Fajardo, Po-Yu Sung, Polly Roy
doaj   +1 more source

Reovirus Low-Density Particles Package Cellular RNA

Viruses, 2021
Packaging of segmented, double-stranded RNA viral genomes requires coordination of viral proteins and RNA segments. For mammalian orthoreovirus (reovirus), evidence suggests either all ten or zero viral RNA segments are simultaneously packaged in a ...
Timothy W. Thoner, Xiang Ye, John Karijolich, Kristen M. Ogden   +3 more
doaj   +1 more source

Influence of gag and RRE Sequences on HIV-1 RNA Packaging Signal Structure and Function [PDF]

Journal of Molecular Biology, 2018
Siarhei Kharytonchyk, Alice Telesnitsky, Aishwarya Iyer   +2 more
exaly   +2 more sources