Results 1 to 10 of about 10,474 (120)
RNA Biology, 2022 RNA translation is the rate-limiting step when cells synthesize proteins. Elevating translation efficiency (TE) is intuitively beneficial. Particularly, when viruses invade host cells, how to compete with endogenous RNAs for efficient translation is a ...
Lin Zhu +4 more
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Topology of RNA-RNA Interaction Structures [PDF]
Journal of Computational Biology, 2012 40 pages 15 ...
Jørgen E. Andersen +3 more
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Irreducibility in RNA Structures [PDF]
Bulletin of Mathematical Biology, 2009 In this paper we study irreducibility in RNA structures. By RNA structure we mean RNA secondary as well as RNA pseudoknot structures. In our analysis we shall contrast random and minimum free energy (mfe) configurations. We compute various distributions: of the numbers of irreducible substructures, their locations and sizes, parameterized in terms of ...
Jin, Emma Y., Reidys, Christian M.
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Alternate RNA Structures [PDF]
Cold Spring Harbor Perspectives in Biology, 2020 RNA molecules fold into complex three-dimensional structures that sample alternate conformations ranging from minor differences in tertiary structure dynamics to major differences in secondary structure. This allows them to form entirely different substructures with each population potentially giving rise to a distinct biological outcome.
Marie Teng-Pei, Wu, Victoria, D'Souza
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Deconstructing internal ribosome entry site elements: an update of structural motifs and functional divergences [PDF]
Open Biology, 2018 Beyond the general cap-dependent translation initiation, eukaryotic organisms use alternative mechanisms to initiate protein synthesis. Internal ribosome entry site (IRES) elements are cis-acting RNA regions that promote internal initiation of ...
Gloria Lozano +2 more
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Alignments of RNA Structures [PDF]
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2010 We describe a theoretical unifying framework to express the comparison of RNA structures, which we call alignment hierarchy. This framework relies on the definition of common supersequences for arc-annotated sequences and encompasses the main existing models for RNA structure comparison based on trees and arc-annotated sequences with a variety of edit ...
Blin, Guillaume +4 more
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Flexible pri-miRNA structures enable tunable production of 5’ isomiRs
RNA Biology, 2022 The Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5’ isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we performed
Xavier Bofill-De Ros +6 more
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SS/SW BASE PAIRS ARE THE ONLY BASE PAIRS INVOLVED IN LONG-RANGE RNA TERTIARY MOTIFS
Journal of Bioinformatics and Genomics, 2020 The structure of noncoding RNAs largely determines their functions. With the rapid growth of experimental data on the RNA secondary structures, the task of predicting its spatial structure becomes the most urgent task of RNA bioinformatics.
Manakov, A.K. +2 more
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Nature Communications, 2023 T-box riboswitches are unique riboregulators where gene regulation is mediated through interactions between two highly structured RNAs. Despite extensive structural insights, how RNA-RNA interactions drive the folding and structural transitions of T-box ...
Xiaolin Niu +5 more
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Recent Advances in Targeted Nanocarriers for the Management of Triple Negative Breast Cancer
Pharmaceutics, 2023 Triple-negative breast cancer (TNBC) is a life-threatening form of breast cancer which has been found to account for 15% of all the subtypes of breast cancer.
Rajesh Pradhan +5 more
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