Results 41 to 50 of about 1,038,708 (317)

The influence of viral RNA secondary structure on interactions with innate host cell defences [PDF]

open access: yes, 2013
RNA viruses infecting vertebrates differ fundamentally in their ability to establish persistent infections with markedly different patterns of transmission, disease mechanisms and evolutionary relationships with their hosts.
Blundell, Richard   +13 more
core   +1 more source

Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

open access: yesCell Reports, 2019
Summary: MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity.
Xavier Bofill-De Ros   +11 more
doaj   +1 more source

VfoldCPX Server: Predicting RNA-RNA Complex Structure and Stability. [PDF]

open access: yesPLoS ONE, 2016
RNA-RNA interactions are essential for genomic RNA dimerization, mRNA splicing, and many RNA-related gene expression and regulation processes. The prediction of the structure and folding stability of RNA-RNA complexes is a problem of significant ...
Xiaojun Xu, Shi-Jie Chen
doaj   +1 more source

Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components

open access: yesNature Communications, 2018
The mitochondrial RNA degradosome (mtEXO) plays an essential role in the regulation of mitochondrial gene expression and is composed of the 3′-to-5′ exoribonuclease Dss1 and the helicase Suv3.
Michal Razew   +12 more
doaj   +1 more source

Topological Classification of RNA Structures [PDF]

open access: yesJournal of Molecular Biology, 2008
We present a novel topological classification of RNA secondary structures with pseudoknots. It is based on the topological genus of the circular diagram associated to the RNA base-pair structure. The genus is a positive integer number, whose value quantifies the topological complexity of the folded RNA structure.
Bon, Michael   +3 more
openaire   +3 more sources

A comprehensive comparison of comparative RNA structure prediction approaches

open access: yes, 2004
Gardner PP, Giegerich R. A comprehensive comparison of comparative RNA structure prediction approaches. BMC Bioinformatics. 2004;5(1): 140.Background: An increasing number of researchers have released novel RNA structure analysis and prediction ...
Giegerich, R.   +7 more
core   +1 more source

On the Structure of RNA Branching Polytopes [PDF]

open access: yesSIAM Journal on Applied Algebra and Geometry, 2018
The prevalent method for RNA secondary structure prediction for a single sequence is free energy minimization based on the nearest neighbor thermodynamic model (NNTM). One of the least well-developed parts of the model is the energy function assigned to the multibranch loops.
Fidel Barrera-Cruz   +2 more
openaire   +3 more sources

Prediction of RNA Secondary Structure Including Kissing Hairpin Motifs

open access: yes, 2010
Theis C, Janssen S, Giegerich R. Prediction of RNA Secondary Structure Including Kissing Hairpin Motifs. In: Moulton V, Singh M, eds. Algorithms in Bioinformatics. 10th international workshop (WABI 2010), proceedings. Lecture Notes in Bioinformatics. Vol
Corinna Theis   +7 more
core   +1 more source

A normal genetic variation modulates synaptic MMP‐9 protein levels and the severity of schizophrenia symptoms

open access: yesEMBO Molecular Medicine, 2017
Matrix metalloproteinase 9 (MMP‐9) has recently emerged as a molecule that contributes to pathological synaptic plasticity in schizophrenia, but explanation of the underlying mechanisms has been missing.
Katarzyna Lepeta   +10 more
doaj   +1 more source

RNA structure determination: From 2D to 3D

open access: yesFundamental Research, 2023
RNA molecules serve a wide range of functions that are closely linked to their structures. The basic structural units of RNA consist of single- and double-stranded regions.
Jie Deng   +8 more
doaj   +1 more source

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