Results 51 to 60 of about 1,628,380 (301)

RNA 3D Modules in Genome-Wide Predictions of RNA 2D Structure. [PDF]

PLoS ONE, 2015
Recent experimental and computational progress has revealed a large potential for RNA structure in the genome. This has been driven by computational strategies that exploit multiple genomes of related organisms to identify common sequences and secondary ...
Corinna Theis, Craig L Zirbel, Christian Höner Zu Siederdissen, Christian Anthon, Ivo L Hofacker, Henrik Nielsen, Jan Gorodkin   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Combinatorial RNA Design: Designability and Structure-Approximating Algorithm [PDF]

, 2015
In this work, we consider the Combinatorial RNA Design problem, a minimal instance of the RNA design problem which aims at finding a sequence that admits a given target as its unique base pair maximizing structure.
A Avihoo, A Busch, A Esmaili-Taheri, A Levin, A Taneda, C Höner Zu Siederdissen, DH Mathews, DH Turner, G Rodrigo, IL Hofacker, JA Garcia-Martin, JN Zadeh, M Zuker, MK Takahashi, R Aguirre-Hernández, R Nussinov, RB Lyngsø, S Griffiths-Jones, SY Wu, V Reinharz, Y Frid   +20 more
core   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The dual role of Spn-E in supporting heterotypic ping-pong piRNA amplification in silkworms

EMBO Reports
The PIWI-interacting RNA (piRNA) pathway plays a crucial role in silencing transposons in the germline. piRNA-guided target cleavage by PIWI proteins triggers the biogenesis of new piRNAs from the cleaved RNA fragments.
Natsuko Izumi, Keisuke Shoji, Lumi Negishi, Yukihide Tomari   +3 more
doaj   +1 more source

PATTERNA: transcriptome-wide search for functional RNA elements via structural data signatures. [PDF]

, 2018
Establishing a link between RNA structure and function remains a great challenge in RNA biology. The emergence of high-throughput structure profiling experiments is revolutionizing our ability to decipher structure, yet principled approaches for ...
Aviran, Sharon, Ledda, Mirko
core  

Ab initio RNA folding

, 2014
RNA molecules are essential cellular machines performing a wide variety of functions for which a specific three-dimensional structure is required. Over the last several years, experimental determination of RNA structures through X-ray crystallography and
Cragnolini, Tristan, Derreumaux, Philippe, Pasquali, Samuela   +2 more
core   +3 more sources

RNA movies: visualizing RNA secondary structure spaces. [PDF]

Bioinformatics, 1999
Abstract MOTIVATION: RNA Movies is a system for the visualization of RNA secondary structure spaces. Its input is a script consisting of primary and secondary structure information. From this script, the system fully automatically generates animated graphical structure representations.
Evers, Dirk J., Giegerich, Robert
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

RNA secondary structure formation: a solvable model of heteropolymer folding

, 1999
The statistical mechanics of heteropolymer structure formation is studied in the context of RNA secondary structures. A designed RNA sequence biased energetically towards a particular native structure (a hairpin) is used to study the transition between ...
D. Poland, E. I. Shakhnovich, E. Zuo, G. Parisi, J. G. Wetmur, J. N. Onuchic, J. S. McCaskill, K. A. Dill, M. S. Waterman, M. Zuker, N. Go¯, P. G. de Gennes, P. G. Higgs, P. Higgs, R. Bundschuh, S. J. Chen, T. C. Lubensky, T. Garel, T. Hwa, T. Hwa, V. Muñoz, W. Sanger   +21 more
core   +1 more source