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A New Method of RNA Secondary Structure Prediction Based on Convolutional Neural Network and Dynamic Programming

open access: yesFrontiers in Genetics, 2019
In recent years, obtaining RNA secondary structure information has played an important role in RNA and gene function research. Although some RNA secondary structures can be gained experimentally, in most cases, efficient, and accurate computational ...
Hao Zhang   +6 more
doaj   +3 more sources

Structural 3D Domain Reconstruction of the RNA Genome from Viruses with Secondary Structure Models

open access: yesViruses, 2021
Three-dimensional RNA domain reconstruction is important for the assembly, disassembly and delivery functionalities of a packed proteinaceus capsid. However, to date, the self-association of RNA molecules is still an open problem. Recent chemical probing
Simón Poblete, Horacio V. Guzman
doaj   +1 more source

Long non-coding RNA-polycomb intimate rendezvous [PDF]

open access: yesOpen Biology, 2020
The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the HOX transcript antisense RNA (HOTAIR), has been the subject of intense debate.
Andrea Cerase, Gian Gaetano Tartaglia
doaj   +1 more source

RNAlign2D: a rapid method for combined RNA structure and sequence-based alignment using a pseudo-amino acid substitution matrix

open access: yesBMC Bioinformatics, 2021
Background The functions of RNA molecules are mainly determined by their secondary structures. These functions can also be predicted using bioinformatic tools that enable the alignment of multiple RNAs to determine functional domains and/or classify RNA ...
Tomasz Woźniak   +3 more
doaj   +1 more source

RNA Secondary Structure Prediction [PDF]

open access: yesCurrent Protocols in Nucleic Acid Chemistry, 2000
AbstractDetails for predicting secondary structure of RNA sequences using free energy minimization are given. Protocols present the use of the RNAstructure computer program (for PCs) and the mfold server (for Unix platforms). The minimum free energy structure and a set of suboptimal structures with similar free energies are predicted.
Mathews, David H.   +2 more
openaire   +5 more sources

RNA secondary structure factorization in prime tangles

open access: yesBMC Bioinformatics, 2022
Background Due to its key role in various biological processes, RNA secondary structures have always been the focus of in-depth analyses, with great efforts from mathematicians and biologists, to find a suitable abstract representation for modelling its ...
Daniele Marchei, Emanuela Merelli
doaj   +1 more source

SSRTool: A web tool for evaluating RNA secondary structure predictions based on species-specific functional interpretability

open access: yesComputational and Structural Biotechnology Journal, 2022
RNA secondary structures can carry out essential cellular functions alone or interact with one another to form the hierarchical tertiary structures.
Tzu-Hsien Yang   +3 more
doaj   +1 more source

Widespread selection for extremely high and low levels of secondary structure in coding sequences across all domains of life [PDF]

open access: yesOpen Biology, 2019
Codon composition, GC content and local RNA secondary structures can have a profound effect on gene expression, and mutations affecting these parameters, even though they do not alter the protein sequence, are not neutral in terms of selection.
Daniel Gebert   +2 more
doaj   +1 more source

RNA secondary structure design [PDF]

open access: yesPhysical Review E, 2007
11 pages, 10 ...
Burghardt, Bernd, Hartmann, Alexander K.
openaire   +4 more sources

Designing RNA Secondary Structures Is Hard [PDF]

open access: yesJournal of Computational Biology, 2020
A ribonucleic acid (RNA) sequence is a word over an alphabet on four elements { A , C , G
Bonnet, Edouard   +2 more
openaire   +6 more sources

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