Results 41 to 50 of about 107,453 (245)
Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses
mBio, 2018 Selective packaging is a mechanism used by multiple virus families to specifically incorporate genomic RNA (gRNA) into virions and exclude other types of RNA. Lineage A betacoronaviruses incorporate a 95-bp stem-loop structure, the packaging signal (PS),
Jeremiah Athmer +11 more
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Cell biology of retroviral RNA packaging [PDF]
RNA Biology, 2011 Generation of infectious retroviral particles rely on the targeting of all structural components to the correct cellular sites at the correct time. Gag, the main structural protein, orchestrates the assembly process and the mechanisms that trigger its targeting to assembly sites are well described. Gag is also responsible for the packaging of the viral
Nolwenn, Jouvenet +3 more
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Expression of IMP1 enhances production of murine leukemia virus vector by facilitating viral genomic RNA packaging. [PDF]
PLoS ONE, 2010 Murine leukemia virus (MLV)-based retroviral vector is widely used for gene transfer. Efficient packaging of the genomic RNA is critical for production of high-titer virus. Here, we report that expression of the insulin-like growth factor II mRNA binding
Yun Mai, Guangxia Gao
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Cooperative Mechanism of RNA Packaging Motor [PDF]
Journal of Biological Chemistry, 2005 P4 is a hexameric ATPase that serves as the RNA packaging motor in double-stranded RNA bacteriophages from the Cystoviridae family. P4 shares sequence and structural similarities with hexameric helicases. A structure-based mechanism for mechano-chemical coupling has recently been proposed for P4 from bacteriophage phi12.
Jirí, Lísal, Roman, Tuma
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NMR Studies of Retroviral Genome Packaging
Viruses, 2020 Nearly all retroviruses selectively package two copies of their unspliced RNA genomes from a cellular milieu that contains a substantial excess of non-viral and spliced viral RNAs.
Patricia S. Boyd +12 more
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RNA: packaged and protected by VLPs
RSC Advances, 2018 VLP packaging is most efficient for compact RNA, and protects RNA against assault by small diffusible damaging agents.
Po-Yu Fang +4 more
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Alphavirus Nucleocapsid Packaging and Assembly
Viruses, 2018 Alphavirus nucleocapsids are assembled in the cytoplasm of infected cells from 240 copies of the capsid protein and the approximately 11 kb positive strand genomic RNA.
Adriano Mendes, Richard J. Kuhn
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RNA packaging in lentiviruses [PDF]
Retrovirology, 2009 The selection by a lentivirus of its genomic RNA from the background of a vast excess of cellular messenger RNAs and sub-genomic viral RNAs occurs with high specificity. The nature and site of the specific interaction between the unspliced RNA genome and the gag polyprotein, which is responsible for its capture, is still poorly understood and the ...
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pyrpipe : a Python package for RNA-Seq workflows [PDF]
NAR Genomics and Bioinformatics, 2020 Abstract The availability of terabytes of RNA-Seq data and continuous emergence of new analysis tools, enable unprecedented biological insight. There is a pressing requirement for a framework that allows for fast, efficient, manageable, and reproducible RNA-Seq analysis.
Urminder Singh +3 more
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How to package the RNA of HIV-1
eLife, 2020 Interactions between viral RNA and the integrase enzyme are required for HIV-1 particles to become infectious, a process that can be disrupted through multiple mechanisms.
Alex Kleinpeter, Eric O Freed
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