Results 41 to 50 of about 113,079 (105)

Coronavirus genome packaging and nucleocapsid assembly

Journal of Virology
Coronaviruses are a family of positive-strand RNA viruses that exhibit highly selective packaging of their genomic RNA (gRNA) into assembled virions, despite the presence of a large excess of subgenomic viral RNA species and host RNA in infected cells ...
Paul S. Masters
doaj   +1 more source

Structural dynamics of retroviral genome and the packaging

Frontiers in Microbiology, 2011
Retroviruses can cause diseases such as AIDS, leukemia and tumors, but are also used as vectors for human gene therapy. All retroviruses, except foamy viruses, package two copies of unspliced genomic RNA into their progeny viruses.
Yasuyuki eMiyazaki, Ariko eMiyake, Masako eNomaguchi, Akio eAdachi   +3 more
doaj   +1 more source

Analysis of the contribution of cellular and viral RNA to the packaging of APOBEC3G into HIV-1 virions

Retrovirology, 2007
Background Efficient incorporation of the cellular cytidine deaminase APOBEC3G (APO3G) into HIV-1 virions is necessary for its antiviral activity. Even though cellular RNAs are known to be non-specifically incorporated into virus particles, we have ...
Kao Sandra, Takeuchi Hiroaki, Miyagi Eri, Opi Sandrine, Goila-Gaur Ritu, Khan Mohammad A, Strebel Klaus   +6 more
doaj   +1 more source

Essential role of cis-encoded mature NS3 in the genome packaging of classical swine fever virus

Journal of Virology
Classical swine fever virus (CSFV) is a member of the genus Pestivirus within the family Flaviviridae. The enveloped particles contain a plus-stranded RNA genome encoding a single large polyprotein.
Benjamin Lamp, Sandra Barth, Carina Reuscher, Sebastian Affeldt, Angelika Cechini, Anette Netsch, Irmin Lobedank, Till Rümenapf   +7 more
doaj   +1 more source

Opening of the TAR hairpin in the HIV-1 genome causes aberrant RNA dimerization and packaging

Retrovirology, 2012
Background The TAR hairpin is present at both the 5′ and 3′ end of the HIV-1 RNA genome. The 5′ element binds the viral Tat protein and is essential for Tat-mediated activation of transcription.
Das Atze T, Vrolijk Martine M, Harwig Alex, Berkhout Ben   +3 more
doaj   +1 more source

Visualization of Bluetongue Virus RNA Segment Networks in Infected Cells: Multipartite Genomic RNA Assortment Is Independent of Viral Proteins NS2 and VP6

Viruses
Bluetongue virus (BTV), with a genome of ten double-stranded RNA segments (S1–S10), is an emerging animal pathogen causing major economic losses in livestock worldwide.
Dong-Sheng Luo, Po-Yu Sung, Polly Roy
doaj   +1 more source

Impaired RNA incorporation and dimerization in live attenuated leader-variants of SIV_mac239

Retrovirology, 2006
Background The 5' untranslated region (UTR) or leader sequence of simian immunodeficiency virus (SIVmac239) is multifunctional and harbors the regulatory elements for viral replication, persistence, gene translation, expression, and the packaging and ...
Whitney James B, Wainberg Mark A
doaj   +1 more source

Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation [PDF]

J Biol Chem, 2022
Carlson CR, Adly AN, Bi M, Cheng Y, Morgan DO.   +4 more
europepmc   +2 more sources

RNA Virus Evolution via a Quasispecies-Based Model Reveals a Drug Target with a High Barrier to Resistance

Viruses, 2017
The rapid occurrence of therapy-resistant mutant strains provides a challenge for anti-viral therapy. An ideal drug target would be a highly conserved molecular feature in the viral life cycle, such as the packaging signals in the genomes of RNA viruses ...
Richard J. Bingham, Eric C. Dykeman, Reidun Twarock   +2 more
doaj   +1 more source

Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles

Molecular Therapy: Methods & Clinical Development, 2015
RNA delivery is an attractive strategy to achieve transient gene expression in research projects and in cell- or gene-based therapies. Despite significant efforts investigating vector-directed RNA transfer, there is still a requirement for better ...
Anne Prel, Vincent Caval, Régis Gayon, Philippe Ravassard, Christine Duthoit, Emmanuel Payen, Leila Maouche-Chretien, Alison Creneguy, Tuan Huy Nguyen, Nicolas Martin, Eric Piver, Raphaël Sevrain, Lucille Lamouroux, Philippe Leboulch, Frédéric Deschaseaux, Pascale Bouillé, Luc Sensébé, Jean-Christophe Pagès   +17 more
doaj   +1 more source