Packaging signal of influenza A virus [PDF]
Virology Journal, 2021 Influenza A virus (IAV) contains a genome with eight single-stranded, negative-sense RNA segments that encode 17 proteins. During its assembly, all eight separate viral RNA (vRNA) segments are incorporated into virions in a selective manner.
Xiuli Li +4 more
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Kinetic Studies on the Interaction of HIV-1 Gag Protein with the HIV-1 RNA Packaging Signal [PDF]
VirusesDuring HIV-1 virus assembly, the genomic RNA (vRNA) is selected for packaging by the viral protein Gag because it contains a specific packaging signal, Psi. While there have been numerous studies of Gag–Psi interactions, there is almost no information on
Constance Rink +3 more
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Quantitative analysis of preferential utilization of AAV ITR as the packaging terminal signal
Frontiers in Bioengineering and Biotechnology, 2023 Genetic engineering advances have led to recombinant adeno-associated virus (rAAV) becoming an invaluable tool for the development of effective gene therapies.
Xin Li +8 more
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Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirus [PDF]
Journal of Biomedical Science, 2018 Background Middle East respiratory syndrome coronavirus (MERS-CoV) consists of a positive-sense, single-stranded RNA genome and four structural proteins: the spike, envelope, membrane, and nucleocapsid protein. The assembly of the viral genome into virus
Wei-Chen Hsin +6 more
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Identification of the 5′-Terminal Packaging Signal of the H1N1 Influenza A Virus Neuraminidase Segment at Single-Nucleotide Resolution [PDF]
Frontiers in Microbiology, 2021 The genome of the influenza A virus is an eight-segmented negative-strand RNA (vRNA). Progeny vRNAs replicated in the nucleus selectively assemble into a single set of eight different segments, probably in the cytoplasm, and are packaged into progeny ...
Erika Seshimo +4 more
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Identification of the SARS-CoV-2 genome packaging signal in the nsp12-coding region [PDF]
Nature CommunicationsSelective genome packaging is a critical step for RNA viruses, which must distinguish genomic RNA from other abundant transcripts. For SARS-CoV-2, the cis-acting packaging signal is thought to be recognized by the nucleocapsid (N) protein, but its ...
Youngran Park +6 more
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Efficient support of virus-like particle assembly by the HIV-1 packaging signal [PDF]
eLife, 2018 The principal structural component of a retrovirus particle is the Gag protein. Retroviral genomic RNAs contain a ‘packaging signal’ (‘Ψ') and are packaged in virus particles with very high selectivity.
Mauricio Comas-Garcia +5 more
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Dissection of specific binding of HIV-1 Gag to the 'packaging signal' in viral RNA [PDF]
eLife, 2017 Selective packaging of HIV-1 genomic RNA (gRNA) requires the presence of a cis-acting RNA element called the ‘packaging signal’ (Ψ). However, the mechanism by which Ψ promotes selective packaging of the gRNA is not well understood.
Mauricio Comas-Garcia +5 more
doaj +2 more sources
Involvement of 5′ and 3′ UTRs in SARS-CoV-2 Virus-like Particle Genome Packaging [PDF]
VirusesThe molecular mechanisms governing the efficient packaging of the large SARS-CoV-2 RNA genome into progeny virions remain incompletely understood, with the role of untranslated regions (UTRs) being particularly enigmatic.
Zhang Zhang +12 more
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Influence of gag and RRE Sequences on HIV-1 RNA Packaging Signal Structure and Function. [PDF]
J Mol Biol, 2018 Kharytonchyk S +7 more
europepmc +2 more sources