Packaging signal of influenza A virus [PDF]
Virology Journal, 2021 Influenza A virus (IAV) contains a genome with eight single-stranded, negative-sense RNA segments that encode 17 proteins. During its assembly, all eight separate viral RNA (vRNA) segments are incorporated into virions in a selective manner.
Xiuli Li +4 more
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Kinetic Studies on the Interaction of HIV-1 Gag Protein with the HIV-1 RNA Packaging Signal [PDF]
VirusesDuring HIV-1 virus assembly, the genomic RNA (vRNA) is selected for packaging by the viral protein Gag because it contains a specific packaging signal, Psi. While there have been numerous studies of Gag–Psi interactions, there is almost no information on
Constance Rink +3 more
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The heart of the HIV RNA packaging signal? [PDF]
Proc Natl Acad Sci U S A, 2020 Mechanisms ensuring faithful reproduction are enforced for viruses, as for all other organisms, by natural selection. As a virus particle is a package containing the viral genome (RNA or DNA, as the case may be) for replication and transmission to the next generation, it is essential that the genome be packaged into the assembling virus particle with ...
Rein A.
europepmc +4 more sources
Identification of the 5′-Terminal Packaging Signal of the H1N1 Influenza A Virus Neuraminidase Segment at Single-Nucleotide Resolution [PDF]
Frontiers in Microbiology, 2021 The genome of the influenza A virus is an eight-segmented negative-strand RNA (vRNA). Progeny vRNAs replicated in the nucleus selectively assemble into a single set of eight different segments, probably in the cytoplasm, and are packaged into progeny ...
Erika Seshimo +4 more
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Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirus [PDF]
Journal of Biomedical Science, 2018 Background Middle East respiratory syndrome coronavirus (MERS-CoV) consists of a positive-sense, single-stranded RNA genome and four structural proteins: the spike, envelope, membrane, and nucleocapsid protein. The assembly of the viral genome into virus
Wei-Chen Hsin +6 more
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Multi-Objective Optimization for Through-Silicon via Structure Considering Thermomechanical Reliability and Electrical Performance [PDF]
MicromachinesThe rapid advancement of high-performance computing has spurred growing demand for miniaturized, high-density, high-power, and highly reliable electronic packaging.
Siyi Chen +8 more
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Efficient support of virus-like particle assembly by the HIV-1 packaging signal [PDF]
eLife, 2018 The principal structural component of a retrovirus particle is the Gag protein. Retroviral genomic RNAs contain a ‘packaging signal’ (‘Ψ') and are packaged in virus particles with very high selectivity.
Mauricio Comas-Garcia +5 more
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Alphavirus Nucleocapsid Packaging and Assembly
Viruses, 2018 Alphavirus nucleocapsids are assembled in the cytoplasm of infected cells from 240 copies of the capsid protein and the approximately 11 kb positive strand genomic RNA.
Adriano Mendes, Richard J. Kuhn
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Dissection of specific binding of HIV-1 Gag to the 'packaging signal' in viral RNA [PDF]
eLife, 2017 Selective packaging of HIV-1 genomic RNA (gRNA) requires the presence of a cis-acting RNA element called the ‘packaging signal’ (Ψ). However, the mechanism by which Ψ promotes selective packaging of the gRNA is not well understood.
Mauricio Comas-Garcia +5 more
doaj +2 more sources
Direct Evidence for Packaging Signal-Mediated Assembly of Bacteriophage MS2. [PDF]
J Mol Biol, 2016 Using cross-linking coupled to matrix-assisted laser desorption/ionization mass spectrometry and CLIP-Seq sequencing, we determined the peptide and oligonucleotide sequences at the interfaces between the capsid proteins and the genomic RNA of bacteriophage MS2.
Rolfsson Ó +11 more
europepmc +7 more sources