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Dengue Virus Genome Uncoating Requires Ubiquitination [PDF]
mBio, 2016 The process of genome release or uncoating after viral entry is one of the least-studied steps in the flavivirus life cycle. Flaviviruses are mainly arthropod-borne viruses, including emerging and reemerging pathogens such as dengue, Zika, and West Nile ...
Laura A. Byk +5 more
doaj +8 more sources
Viral Genome Deep Classifier [PDF]
IEEE Access, 2019 The task of virus classification into subtypes is an important concern in many categorization studies, e.g., in virology or epidemiology. Therefore, the problem of virus subtyping has been a subject of considerable interest in the last decade.
Anna Fabijanska, Szymon Grabowski
doaj +2 more sources
The accessibility of the HSV genome during productive infection can vary in different cell types and affect the outcome of infection [PDF]
mBioDuring productive herpes simplex virus type 1 (HSV-1) infection, the viral genome encounters a number of cellular and viral proteins, such as ICP4, which engage in processes that either attenuate or activate transcription.
Jenna M. Nosek +2 more
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Approaches to quantifying hepatitis B virus covalently closed circular DNA [PDF]
Clinical and Molecular Hepatology, 2022 Chronic hepatitis B is a major cause of liver disease worldwide and is currently incurable. Hepatitis B virus (HBV) covalently closed circular (ccc) DNA is a key form of the virus responsible for its persistence and is the transcriptional template for ...
Henrik Zhang, Thomas Tu
doaj +1 more source
Expansion of Viral Genomes with Viral Protein Genome Linked Copies
SSRN Electronic Journal, 2022 Virus protein-linked genome (VPg) proteins are required for replication. VPgs are duplicated in a subset of RNA viruses however their roles are not fully understood and the extent of viral genomes containing VPg copies has not been investigated in detail.
Reid, Warsaba +3 more
openaire +2 more sources
Informative Regions In Viral Genomes [PDF]
Viruses, 2021 Viruses, far from being just parasites affecting hosts’ fitness, are major players in any microbial ecosystem. In spite of their broad abundance, viruses, in particular bacteriophages, remain largely unknown since only about 20% of sequences obtained from viral community DNA surveys could be annotated by comparison with public databases.
Jaime Leonardo Moreno-Gallego +1 more
openaire +6 more sources
Potential Application of the CRISPR/Cas9 System against Herpesvirus Infections. [PDF]
, 2018 The CRISPR/Cas9 system has been applied in the genome editing and disruption of latent infections for herpesviruses such as the herpes simplex virus, Epstein⁻Barr virus, cytomegalovirus, and Kaposi's sarcoma-associated herpesvirus.
Chen, Yuan-Chuan +3 more
core +9 more sources
The Role of the Stem-Loop A RNA Promoter in Flavivirus Replication
Viruses, 2021 An essential challenge in the lifecycle of RNA viruses is identifying and replicating the viral genome amongst all the RNAs present in the host cell cytoplasm. Yet, how the viral polymerase selectively recognizes and copies the viral RNA genome is poorly
Kyung H. Choi
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Viral component of the human genome [PDF]
Molecular Biology, 2017 Relationships between viruses and their human host are traditionally described from the point of view taking into consideration hosts as victims of viral aggression, which results in infectious diseases. However, these relations are in fact two-sided and involve modifications of both the virus and host genomes.
Blinov, V. M. +4 more
openaire +3 more sources
NCBI Viral Genomes Resource [PDF]
Nucleic Acids Research, 2014 Recent technological innovations have ignited an explosion in virus genome sequencing that promises to fundamentally alter our understanding of viral biology and profoundly impact public health policy. Yet, any potential benefits from the billowing cloud of next generation sequence data hinge upon well implemented reference resources that facilitate ...
J. Rodney Brister +3 more
openaire +2 more sources