Results 11 to 20 of about 516,597 (217)

Viral Genome Deep Classifier

IEEE Access, 2019
The task of virus classification into subtypes is an important concern in many categorization studies, e.g., in virology or epidemiology. Therefore, the problem of virus subtyping has been a subject of considerable interest in the last decade.
Anna Fabijanska, Szymon Grabowski
doaj   +1 more source

Subcellular distribution of the rAAV genome depends on genome structure

Scientific Reports, 2023
Many studies have been conducted on the transduction efficiency of recombinant adeno-associated virus (rAAV) depending on the serotype and genome structure, such as single-stranded (ss) and self-complementary (sc).
Nuri Oh, Naresh H. Tarte
doaj   +1 more source

Telomeres and Viruses: Common Themes of Genome Maintenance

Frontiers in Oncology, 2012
Genome maintenance mechanisms actively suppress genetic instability associated with cancer and aging. Some viruses provoke genetic instability by subverting the host’s control of genome maintenance.
Zhong eDeng, Zhuo eWang, Paul M Lieberman   +2 more
doaj   +1 more source

Transcriptomics Reveal Antiviral Gene Induction in the Egyptian Rousette Bat Is Antagonized In Vitro by Marburg Virus Infection

Viruses, 2018
The Egyptian rousette bat (ERB) is the only known Marburg virus (MARV) reservoir host. ERBs develop a productive MARV infection with low viremia and shedding but no overt disease, suggesting this virus is efficiently controlled by ERB antiviral responses.
Catherine E. Arnold, Jonathan C. Guito, Louis A. Altamura, Sean P. Lovett, Elyse R. Nagle, Gustavo F. Palacios, Mariano Sanchez-Lockhart, Jonathan S. Towner   +7 more
doaj   +1 more source

Isolation, Characterization, and Differentiation Potential of Canine Adipose-Derived Stem Cells

Cell Transplantation, 2010
Adipose tissue may represent a potential source of adult stem cells for tissue engineering applications in veterinary medicine. It can be obtained in large quantities, under local anesthesia, and with minimal discomfort.
N. M. Vieira, V. Brandalise, E. Zucconi, M. Secco, B. E. Strauss, M. Zatz Ph.D.   +5 more
doaj   +1 more source

Public genomic visibility of Lassa virus in West Africa: mapping sequence availability, ecological risk, and surveillance gaps

Critical Public Health
Introduction Lassa fever is a major zoonotic infection in West Africa, but its true epidemiology is difficult to define because diagnostic access, reporting systems, and surveillance capacity vary across countries.
Jude Oluwapelumi Alao
doaj   +1 more source

The Nuclear DNA Sensor IFI16 Indiscriminately Binds to and Diminishes Accessibility of the HSV-1 Genome to Suppress Infection

mSystems, 2022
Human cells identify invading pathogens and activate immune signaling pathways through a wide array of pattern recognition receptors, including DNA sensors.
Timothy R. Howard, Krystal K. Lum, Michelle A. Kennedy, Ileana M. Cristea   +3 more
doaj   +1 more source

Viral genome integration of canine papillomavirus 16

Papillomavirus Research, 2019
Papillomaviruses infect humans and animals, most often causing benign proliferations on skin or mucosal surfaces. Rarely, these infections persist and progress to cancer.
Jennifer Luff, Michelle Mader, Peter Rowland, Monica Britton, Joseph Fass, Hang Yuan   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source