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Genomic epidemiology of SARS-CoV-2 virus with a bioinformatics platform
Universidad Médica Pinareña, 2020 Introduction: viral epidemics have presented a risk to human health since they can turn into pandemics and affect a large part of the population, especially for poor developing countries. In 2020, the worldwide pandemic of COVID-19 is underway.
Sebastian Iglesias-Osores +4 more
doaj +2 more sources
mSphere, 2016 A novel group of mammalian DNA viruses called elephant endotheliotropic herpesviruses (EEHVs) belonging to the Proboscivirus genus has been associated with nearly 100 cases of highly lethal acute hemorrhagic disease in young Asian elephants worldwide ...
Paul D. Ling +8 more
doaj +1 more source
Packing nanomechanics of viral genomes [PDF]
The European Physical Journal E, 2008 We investigate the osmotic equilibrium between a bulk polyethylene glycol (PEG) solution and DNA tightly packed in a spherical capsid. We base our analysis on the equations of thermodynamic equilibrium in terms of osmotic pressure. The equality between external osmotic pressure of PEG and osmotic pressure of tightly packed DNA gives us the DNA ...
Šiber, Antonio +3 more
openaire +2 more sources
Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution? [PDF]
, 2009 The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based
Anja Ehrhardt +6 more
core +1 more source
Avian Bornaviruses Escape Recognition by the Innate Immune System [PDF]
, 2010 Like other pathogens that readily persist in animal hosts, members of the Bornaviridae family have evolved effective mechanisms to evade the innate immune response.
Kothlow, Sonja +18 more
core +1 more source
INVERTED REPEATS IN VIRAL GENOMES [PDF]
Fluctuation and Noise Letters, 2005 We investigate 738 complete genomes of viruses to detect the presence of short inverted repeats. The number of inverted repeats found is compared with the prediction obtained for a Bernoullian and for a Markovian control model. We find as a statistical regularity that the number of observed inverted repeats is often greater than the one expected in ...
Spano, M. +3 more
openaire +2 more sources
mSphere, 2016 Nearly 100 cases of lethal acute hemorrhagic disease in young Asian elephants have been reported worldwide. All tested cases contained high levels of elephant endotheliotropic herpesvirus (EEHV) DNA in pathological blood or tissue samples.
Paul D. Ling +5 more
doaj +1 more source
The complexity landscape of viral genomes
GigaScience, 2022 Abstract Background Viruses are among the shortest yet highly abundant species that harbor minimal instructions to infect cells, adapt, multiply, and exist. However, with the current substantial availability of viral genome sequences, the scientific repertory lacks a complexity landscape that ...
Jorge Miguel Silva +3 more
openaire +3 more sources
mSphere, 2019 Dysregulated and maladaptive immune responses are at the forefront of human diseases caused by infection with zoonotic viral hemorrhagic fever viruses. Elucidating mechanisms of how the natural animal reservoirs of these viruses coexist with these agents
Joseph Prescott +11 more
doaj +1 more source
The Viral Replication Complex Is Associated with the Virulence of Newcastle Disease Virus [PDF]
, 2010 Virulent strains of Newcastle disease virus ([NDV] also known as avian paramyxovirus type 1) can be discriminated from low-virulence strains by the presence of multiple basic amino acid residues at the proteolytic cleavage site of the fusion (F) protein.
Peeters, B.P.H. +7 more
core +1 more source