Visualization of Bluetongue Virus RNA Segment Networks in Infected Cells: Multipartite Genomic RNA Assortment Is Independent of Viral Proteins NS2 and VP6 [PDF]
VirusesBluetongue virus (BTV), with a genome of ten double-stranded RNA segments (S1–S10), is an emerging animal pathogen causing major economic losses in livestock worldwide.
Dong-Sheng Luo, Po-Yu Sung, Polly Roy
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Trends Microbiol, 2019 Successful replication of the AIDS retrovirus, HIV, requires that its genomic RNA be packaged in assembling virus particles with high fidelity. However, cellular mRNAs can also be packaged under some conditions. Viral RNA (vRNA) contains a 'packaging signal' (ψ) and is packaged as a dimer, with two vRNA monomers joined by a limited number of base pairs.
Rein A.
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Identification of the initial nucleocapsid recognition element in the HIV-1 RNA packaging signal [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Pengfei Ding +2 more
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Sequestering the 5'-cap for viral RNA packaging. [PDF]
Bioessays, 2022 AbstractMany viruses evolved mechanisms for capping the 5′‐ends of their plus‐strand RNAs as a means of hijacking the eukaryotic messenger RNA (mRNA) splicing/translation machinery. Although capping is critical for replication, the RNAs of these viruses have other essential functions including their requirement to be packaged as either genomes or pre ...
Ding P, Summers MF.
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RNA packaging into extracellular vesicles: An orchestra of RNA-binding proteins? [PDF]
J Extracell Vesicles, 2020 AbstractExtracellular vesicles (EVs) are heterogeneous membranous particles released from the cells through different biogenetic and secretory mechanisms. We now conceive EVs as shuttles mediating cellular communication, carrying a variety of molecules resulting from intracellular homeostatic mechanisms.
Fabbiano F +5 more
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The curious case of genome packaging and assembly in RNA viruses infecting plants
Frontiers in Genetics, 2023 Genome packaging is the crucial step for maturation of plant viruses containing an RNA genome. Viruses exhibit a remarkable degree of packaging specificity, despite the probability of co-packaging cellular RNAs.
Tushar Ranjan +9 more
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mBio, 2021 Human immunodeficiency virus type 1 (HIV-1) Gag selects and packages the HIV RNA genome during virus assembly. However, HIV-1 RNA constitutes only a small fraction of the cellular RNA.
Alice Duchon +9 more
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Influence of gag and RRE Sequences on HIV-1 RNA Packaging Signal Structure and Function [PDF]
Journal of Molecular Biology, 2018 Siarhei Kharytonchyk +2 more
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HIV-1 Packaging Visualised by In-Gel SHAPE
Viruses, 2021 HIV-1 packages two copies of its gRNA into virions via an interaction with the viral structural protein Gag. Both copies and their native RNA structure are essential for virion infectivity.
Aaron R. D’Souza +8 more
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Disruption of Specific RNA-RNA Interactions in a Double-Stranded RNA Virus Inhibits Genome Packaging and Virus Infectivity. [PDF]
PLoS Pathogens, 2015 Bluetongue virus (BTV) causes hemorrhagic disease in economically important livestock. The BTV genome is organized into ten discrete double-stranded RNA molecules (S1-S10) which have been suggested to follow a sequential packaging pathway from smallest ...
Teodoro Fajardo, Po-Yu Sung, Polly Roy
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