Results 21 to 30 of about 2,229,811 (302)
Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins
mBio, 2021 Viral envelope glycoproteins are an important structural component on the surfaces of enveloped viruses that direct virus binding and entry and also serve as targets for the host adaptive immune response.
Cheng Man Lun +4 more
doaj +1 more source
Proficient replication of the yeast genome by a viral DNA polymerase [PDF]
, 2016 DNA replication in eukaryotic cells requires minimally three B-family DNA polymerases: Pol α, Pol δ, and Pol ϵ. Pol δ replicates and matures Okazaki fragments on the lagging strand of the replication fork.
Burgers, Peter M +2 more
core +2 more sources
Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation
eLife, 2021 The Rad53 DNA checkpoint protein kinase plays multiple roles in the budding yeast cell response to DNA replication stress. Key amongst these is its enigmatic role in safeguarding DNA replication forks.
Allison W McClure, John FX Diffley
doaj +1 more source
Transparent Replication Using Metaprogramming in Cyan [PDF]
, 2014 Replication can be used to increase the availability of a service by creating many operational copies of its data called replicas. Active replication is a form of replication that has strong consistency semantics, easier to reason about and program ...
Ugliara, Fellipe A. +2 more
core +3 more sources
Distributional Replication [PDF]
Entropy, 2021 A function which transforms a continuous random variable such that it has a specified distribution is called a replicating function. We suppose that functions may be assigned a price, and study an optimization problem in which the cheapest approximation to a replicating function is sought.
openaire +5 more sources
IFITM3 Reduces Retroviral Envelope Abundance and Function and Is Counteracted by glycoGag
mBio, 2020 Interferon-induced transmembrane (IFITM) proteins are encoded by many vertebrate species and exhibit antiviral activities against a wide range of viruses.
Yadvinder S. Ahi +6 more
doaj +1 more source
Nature Communications, 2022 Here the authors describe multiple structures of the replicative helicase MCM2-7 in complex with Dbf4-dependent kinase (DDK). These structures reveal why the kinase specifically recognizes the MCM2-7 double-hexamer over the single-hexamer and explain how
Almutasem Saleh +9 more
doaj +1 more source
Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses [PDF]
, 2017 The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies.
Donald, Claire L. +4 more
core +1 more source
Replication control: Choreographing replication origins [PDF]
Current Biology, 1998 Budding yeast replication origins are activated during S phase according to a predetermined temporal programme. Two recent studies indicate that this programme is executed, at least in part, by the S-phase-promoting cyclins that act to assemble a pre-initiation complex which includes the Cdc45 protein.
openaire +2 more sources
Efficient support of virus-like particle assembly by the HIV-1 packaging signal
eLife, 2018 The principal structural component of a retrovirus particle is the Gag protein. Retroviral genomic RNAs contain a ‘packaging signal’ (‘Ψ') and are packaged in virus particles with very high selectivity.
Mauricio Comas-Garcia +5 more
doaj +1 more source