Results 21 to 30 of about 1,569,783 (304)
Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation
eLife, 2021 The Rad53 DNA checkpoint protein kinase plays multiple roles in the budding yeast cell response to DNA replication stress. Key amongst these is its enigmatic role in safeguarding DNA replication forks.
Allison W McClure, John FX Diffley
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IFITM3 Reduces Retroviral Envelope Abundance and Function and Is Counteracted by glycoGag
mBio, 2020 Interferon-induced transmembrane (IFITM) proteins are encoded by many vertebrate species and exhibit antiviral activities against a wide range of viruses.
Yadvinder S. Ahi +6 more
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Replication fork collisions cause pathological chromosomal amplification in cells lacking RecG DNA translocase [PDF]
, 2009 This is an open access article, shared under a Creative Commons licence. Copyright © 2009 The Authors.Duplication and transmission of chromosomes require precise control of chromosome replication and segregation.
Lloyd, RG +4 more
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DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. [PDF]
, 2002 Alkylating agents, such as methyl methanesulfonate (MMS), damage DNA and activate the DNA damage checkpoint. Although many of the checkpoint proteins that transduce damage signals have been identified and characterized, the mechanism that senses the ...
Lindsay, Howard D. +3 more
core +5 more sources
Nature Communications, 2022 Here the authors describe multiple structures of the replicative helicase MCM2-7 in complex with Dbf4-dependent kinase (DDK). These structures reveal why the kinase specifically recognizes the MCM2-7 double-hexamer over the single-hexamer and explain how
Almutasem Saleh +9 more
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Restriction of Influenza A Virus by SERINC5
mBio, 2022 Serine incorporator 5 (Ser5), a transmembrane protein, has recently been identified as a host antiviral factor against human immunodeficiency virus (HIV)-1 and gammaretroviruses like murine leukemia viruses (MLVs). It is counteracted by HIV-1 Nef and MLV
Kin Kui Lai +5 more
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Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels [PDF]
, 2010 In the metazoan replication timing program, clusters of replication origins located in different subchromosomal domains fire at different times during S phase. We have used Xenopus laevis egg extracts to drive an accelerated replication timing program in
Blow, J. Julian; id_orcid +6 more
core +1 more source
Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins
mBio, 2021 Viral envelope glycoproteins are an important structural component on the surfaces of enveloped viruses that direct virus binding and entry and also serve as targets for the host adaptive immune response.
Cheng Man Lun +4 more
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Microbiology Spectrum, 2022 HIV-1 must package its RNA genome to generate infectious viruses. Recent studies have revealed that during genome packaging, HIV-1 not only excludes cellular mRNAs, but also distinguishes among full-length viral RNAs. Using NL4-3 and MAL molecular clones,
Jonathan M. O. Rawson +5 more
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ACM Computing Surveys, 2005 Data replication is a key technology in distributed systems that enables higher availability and performance. This article surveys optimistic replication algorithms. They allow replica contents to diverge in the short term to support concurrent work practices and tolerate failures in low-quality communication links. The importance of such techniques is
Saito, Yasushi, Shapiro, Marc
openaire +2 more sources