Results 31 to 40 of about 1,569,783 (304)

Efficient support of virus-like particle assembly by the HIV-1 packaging signal

eLife, 2018
The principal structural component of a retrovirus particle is the Gag protein. Retroviral genomic RNAs contain a ‘packaging signal’ (‘Ψ') and are packaged in virus particles with very high selectivity.
Mauricio Comas-Garcia, Tomas Kroupa, Siddhartha AK Datta, Demetria P Harvin, Wei-Shau Hu, Alan Rein   +5 more
doaj   +1 more source

Replication, Replication [PDF]

PS: Political Science & Politics, 1995
Political science is a community enterprise; the community of empirical political scientists needs access to the body of data necessary to replicate existing studies to understand, evaluate, and especially build on this work. Unfortunately, the norms we have in place now do not encourage, or in some cases even permit, this aim.
openaire   +3 more sources

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories [PDF]

, 2010
Replication origins are licensed by loading MCM2-7 hexamers before entry into S phase. However, only similar to 10% of licensed origins are normally used in S phase, with the others remaining dormant.
Blow, J. Julian; id_orcid, Ge, Xin Quan, J. Julian Blow, Xin Quan Ge, Blow, J. Julian   +4 more
core   +1 more source

Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations

mBio, 2021
Although combination antiretroviral (ARV) therapy is highly effective in controlling the progression of HIV disease, drug resistance can be a major obstacle. Recent findings suggest that resistance can develop without ARV target gene mutations.
Yuta Hikichi, Rachel Van Duyne, Phuong Pham, Jennifer L. Groebner, Ann Wiegand, John W. Mellors, Mary F. Kearney, Eric O. Freed   +7 more
doaj   +1 more source

Replication of chaos

Communications in Nonlinear Science and Numerical Simulation, 2013
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Marat U. Akhmet, Mehmet Onur Fen
openaire   +4 more sources

Does the Cytoplasmic Tail Matter? Mechanism of Viral Envelope Glycoprotein Targeting by Membrane-Associated-RING-CH (MARCH) Proteins

Proceedings, 2020
The MARCH family of RING-finger E3 ubiquitin ligases comprise 11 members that have been reported to play a variety of roles in the downregulation of cell-surface proteins involved in adaptive immunity.
Cheng man Lun, Abdul A. Waheed, Eric O. Freed   +2 more
doaj   +1 more source

vtraag/vqr-replication: Replication material

, 2023
First release of replication ...
Vincent Traag
core   +1 more source

Murine leukemia virus (MLV) replication monitored with fluorescent proteins [PDF]

, 2004
Background Cancer gene therapy will benefit from vectors that are able to replicate in tumor tissue and cause a bystander effect. Replication-competent murine leukemia virus (MLV) has been described to have potential as cancer therapeutics, however, MLV ...
Schnierle Barbara S, Sliva Katja, Erlwein Otto, Bittner Alexandra, Erlwein, Otto, Bittner, Alexandra, Sliva, Katja, Schnierle, Barbara   +7 more
core   +2 more sources

HIV-1 Capsid Rapidly Induces Long-Lived CPSF6 Puncta in Non-Dividing Cells, but Similar Puncta Already Exist in Uninfected T-Cells

Viruses
The HIV-1 capsid (CA) protein forms the outer shell of the viral core that is released into the cytoplasm upon infection. CA binds various cellular proteins, including CPSF6, that direct HIV-1 integration into speckle-associated domains in host chromatin.
Anabel Guedán, Megan Burley, Eve R. Caroe, Kate N. Bishop   +3 more
doaj   +1 more source

Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells

Retrovirology, 2023
Background SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and it has been proposed that this is due to phosphorylation of SAMHD1 at T592 in these ...
Ming-Han C. Tsai, Sarah J. Caswell, Elizabeth R. Morris, Melanie C. Mann, Simon Pennell, Geoff Kelly, Harriet C. T. Groom, Ian A. Taylor, Kate N. Bishop   +8 more
doaj   +1 more source